1Q0L
Crystal structure of DXR in complex with fosmidomycin
Summary for 1Q0L
Entry DOI | 10.2210/pdb1q0l/pdb |
Related | 1Q0H 1Q0Q |
Descriptor | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, 3-[FORMYL(HYDROXY)AMINO]PROPYLPHOSPHONIC ACID, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total) |
Functional Keywords | oxidoreductase |
Biological source | Escherichia coli |
Total number of polymer chains | 1 |
Total formula weight | 45333.40 |
Authors | Mac Sweeney, A.,Lange, R.,D'Arcy, A.,Douangamath, A.,Surivet, J.-P.,Oefner, C. (deposition date: 2003-07-16, release date: 2004-07-20, Last modification date: 2023-08-16) |
Primary citation | Mac Sweeney, A.,Lange, R.,Fernandes, R.P.,Schulz, H.,Dale, G.E.,Douangamath, A.,Proteau, P.J.,Oefner, C. The crystal structure of E.coli 1-deoxy-D-xylulose-5-phosphate reductoisomerase in a ternary complex with the antimalarial compound fosmidomycin and NADPH reveals a tight-binding closed enzyme conformation. J.Mol.Biol., 345:115-127, 2005 Cited by PubMed: 15567415DOI: 10.1016/j.jmb.2004.10.030 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
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