1Q0L

Crystal structure of DXR in complex with fosmidomycin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008299	biological_process	isoprenoid biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0019288	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
A	0030145	molecular_function	manganese ion binding
A	0030604	molecular_function	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0051484	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process
A	0070402	molecular_function	NADPH binding
A	1990065	cellular_component	Dxr protein complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE FOM A 399

Chain	Residue
A	SER151
A	GLU231
A	NDP400
A	HOH422
A	HOH433
A	HOH434
A	GLU152
A	GLY185
A	SER186
A	GLY187
A	ILE218
A	SER222
A	ASN227
A	LYS228

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site_id	AC2
Number of Residues	27
Details	BINDING SITE FOR RESIDUE NDP A 400

Chain	Residue
A	GLY8
A	THR10
A	GLY11
A	SER12
A	ILE13
A	ALA35
A	GLY36
A	LYS37
A	ASN38
A	ASP57
A	ALA100
A	ILE101
A	VAL102
A	ALA105
A	ALA123
A	ASN124
A	LYS125
A	GLU126
A	ASP150
A	MET214
A	GLY215
A	ILE218
A	MET276
A	FOM399
A	HOH403
A	HOH460
A	HOH483

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	17
Details	BINDING: BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q

Chain	Residue	Details
A	THR10
A	GLU126
A	SER151
A	SER186
A	HIS209
A	GLY215
A	SER222
A	ASN227
A	LYS228
A	GLY11
A	SER12
A	ILE13
A	GLY36
A	LYS37
A	ASN38
A	ASN124
A	LYS125

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:12621040, ECO:0007744|PDB:1ONO, ECO:0007744|PDB:1ONP

Chain	Residue	Details
A	ASP150
A	GLU152
A	GLU231

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