1Q0L
Crystal structure of DXR in complex with fosmidomycin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0019288 | biological_process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0030604 | molecular_function | 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070402 | molecular_function | NADPH binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE FOM A 399 |
| Chain | Residue |
| A | SER151 |
| A | GLU231 |
| A | NDP400 |
| A | HOH422 |
| A | HOH433 |
| A | HOH434 |
| A | GLU152 |
| A | GLY185 |
| A | SER186 |
| A | GLY187 |
| A | ILE218 |
| A | SER222 |
| A | ASN227 |
| A | LYS228 |
| site_id | AC2 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE NDP A 400 |
| Chain | Residue |
| A | GLY8 |
| A | THR10 |
| A | GLY11 |
| A | SER12 |
| A | ILE13 |
| A | ALA35 |
| A | GLY36 |
| A | LYS37 |
| A | ASN38 |
| A | ASP57 |
| A | ALA100 |
| A | ILE101 |
| A | VAL102 |
| A | ALA105 |
| A | ALA123 |
| A | ASN124 |
| A | LYS125 |
| A | GLU126 |
| A | ASP150 |
| A | MET214 |
| A | GLY215 |
| A | ILE218 |
| A | MET276 |
| A | FOM399 |
| A | HOH403 |
| A | HOH460 |
| A | HOH483 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 17 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15567415","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Q0Q","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12621040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ONO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ONP","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
