3VP4

Crystal structure of human glutaminase in complex with inhibitor 4

Summary for 3VP4

Entry DOI	10.2210/pdb3vp4/pdb
Related	3VOY 3VP0 3VP1 3VP2 3VP3 3VPZ
Descriptor	Glutaminase kidney isoform, mitochondrial, 5,5'-butane-1,4-diylbis(1,3,4-thiadiazol-2-amine) (3 entities in total)
Functional Keywords	hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Isoform 1: Cytoplasm, cytosol. Isoform 3: Mitochondrion: O94925
Total number of polymer chains	1
Total formula weight	35073.09
Authors	Thangavelu, K.,Sivaraman, J. (deposition date: 2012-02-23, release date: 2012-06-13, Last modification date: 2023-11-08)
Primary citation	Thangavelu, K.,Pan, C.Q.,Karlberg, T.,Balaji, G.,Uttamchandani, M.,Suresh, V.,Schuler, H.,Low, B.C.,Sivaraman, J. Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism. Proc.Natl.Acad.Sci.USA, 109:7705-7710, 2012 Cited by PubMed: 22538822 DOI: 10.1073/pnas.1116573109 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.45 Å)

Structure validation