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5WRZ
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Structure of human PARP1 catalytic domain bound to a phthalazinone inhibitor
分子名称: 7-fluoranyl-4-[[(3R)-pyrrolidin-3-yl]methoxy]-2H-phthalazin-1-one, Poly [ADP-ribose] polymerase 1
著者Cao, R, Wang, Y.L, Zhou, J, Huang, N, Xu, B.L.
登録日2016-12-04
公開日2017-01-25
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure of human PARP1 catalytic domain bound to a phthalazinone inhibitor
To Be Published
5WS1
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BU of 5ws1 by Molmil
Structure of human PARP1 catalytic domain bound to a benzoimidazole inhibitor
分子名称: 2-[(3R)-3-azanylpyrrolidin-1-yl]carbonyl-1H-benzimidazole-4-carboxamide, Poly [ADP-ribose] polymerase 1
著者Cao, R, Wang, Y.L, Zhou, J, Huang, N, Xu, B.L.
登録日2016-12-04
公開日2017-01-25
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure of human PARP1 catalytic domain bound to a benzoimidazole inhibitor
To Be Published
5WTC
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Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor
分子名称: 1-[[4-fluoranyl-3-[4-[2,2,2-tris(fluoranyl)ethyl]piperazin-1-yl]carbonyl-phenyl]methyl]quinazoline-2,4-dione, Poly [ADP-ribose] polymerase 1
著者Cao, R, Wang, Y.L, Zhou, J, Huang, N, Xu, B.L.
登録日2016-12-11
公開日2017-01-25
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor
To Be Published
5WRQ
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Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor
分子名称: 5-[[2,4-bis(oxidanylidene)quinazolin-1-yl]methyl]-2-fluoranyl-N-[(3R)-1-(3-methylbutyl)pyrrolidin-3-yl]benzamide, Poly [ADP-ribose] polymerase 1
著者Cao, R, Wang, Y.L, Zhou, J, Huang, N, Xu, B.L.
登録日2016-12-03
公開日2017-01-25
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor
To Be Published
7VDO
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BU of 7vdo by Molmil
Crystal structure of KRED F147L/L153Q/Y190P variant
分子名称: 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-alpha-(Or 20-beta)-hydroxysteroid dehydrogenase, ...
著者Cui, J, Huang, X, Wang, B, Zhao, H, Zhou, J.
登録日2021-09-07
公開日2022-05-11
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.85571563 Å)
主引用文献Photoinduced chemomimetic biocatalysis for enantioselective intermolecular radical conjugate addition
Nat Catal, 2022
7VE7
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BU of 7ve7 by Molmil
Crystal structure of KRED mutant-F147L/L153Q/Y190P/L199A/M205F/M206F
分子名称: 3-alpha-(Or 20-beta)-hydroxysteroid dehydrogenase, MAGNESIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Cui, J, Huang, X, Wang, B, Zhao, H, Zhou, J.
登録日2021-09-08
公開日2022-05-11
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.720007 Å)
主引用文献Photoinduced chemomimetic biocatalysis for enantioselective intermolecular radical conjugate addition
Nat Catal, 2022
6IX8
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The structure of LepI C52A in complex with SAM and its substrate analogue
分子名称: (1R,2R,4aS,8S,8aR)-2,8-dimethyl-5'-phenyl-4a,5,6,7,8,8a-hexahydro-2H,2'H-spiro[naphthalene-1,3'-pyridine]-2',4'(1'H)-dione, 1,2-ETHANEDIOL, ACETATE ION, ...
著者Cai, Y, Ohashi, M, Hai, Y, Tang, Y, Zhou, J.
登録日2018-12-09
公開日2019-07-17
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.659 Å)
主引用文献Structural basis for stereoselective dehydration and hydrogen-bonding catalysis by the SAM-dependent pericyclase LepI.
Nat.Chem., 11, 2019
6IX5
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The structure of LepI complex with SAM and its substrate analogue
分子名称: 1,2-ETHANEDIOL, 4-hydroxy-3-[(2S,6E,8E)-2-methyldeca-6,8-dienoyl]-5-phenylpyridin-2(1H)-one, CHLORIDE ION, ...
著者Cai, Y, Ohashi, M, Hai, Y, Tang, Y, Zhou, J.
登録日2018-12-09
公開日2019-07-17
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural basis for stereoselective dehydration and hydrogen-bonding catalysis by the SAM-dependent pericyclase LepI.
Nat.Chem., 11, 2019
6IX3
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The structure of LepI complex with SAM
分子名称: CHLORIDE ION, O-methyltransferase lepI, S-ADENOSYLMETHIONINE
著者Cai, Y, Ohashi, M, Hai, Y, Tang, Y, Zhou, J.
登録日2018-12-09
公開日2019-07-17
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.13 Å)
主引用文献Structural basis for stereoselective dehydration and hydrogen-bonding catalysis by the SAM-dependent pericyclase LepI.
Nat.Chem., 11, 2019
6IX9
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The structure of LepI C52A in complex with SAM and leporin C
分子名称: (6R,6aS,10S,10aR)-10-methyl-4-phenyl-6-[(1E)-prop-1-en-1-yl]-2,6,6a,7,8,9,10,10a-octahydro-1H-[2]benzopyrano[4,3-c]pyridin-1-one, CHLORIDE ION, GLYCEROL, ...
著者Cai, Y, Ohashi, M, Hai, Y, Tang, Y, Zhou, J.
登録日2018-12-09
公開日2019-07-17
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.776 Å)
主引用文献Structural basis for stereoselective dehydration and hydrogen-bonding catalysis by the SAM-dependent pericyclase LepI.
Nat.Chem., 11, 2019
6IX7
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The structure of LepI C52A in complex with SAH and substrate analogue
分子名称: 1,2-ETHANEDIOL, 4-hydroxy-3-[(2S,6E,8E)-2-methyldeca-6,8-dienoyl]-5-phenylpyridin-2(1H)-one, CHLORIDE ION, ...
著者Cai, Y, Ohashi, M, Hai, Y, Tang, Y, Zhou, J.
登録日2018-12-09
公開日2019-07-17
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.835 Å)
主引用文献Structural basis for stereoselective dehydration and hydrogen-bonding catalysis by the SAM-dependent pericyclase LepI.
Nat.Chem., 11, 2019
7EJI
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Crystal structure of KRED F147L/L153Q/Y190P/L199A/M205F/M206F variant and methyl methacrylate complex
分子名称: 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-oxidanylisoindole-1,3-dione, ...
著者Cui, J, Huang, X, Wang, B, Zhao, H, Zhou, J.
登録日2021-04-02
公開日2022-05-11
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.560016 Å)
主引用文献Photoinduced chemomimetic biocatalysis for enantioselective intermolecular radical conjugate addition
Nat Catal, 2022
7EJJ
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Crystal structure of KRED F147L/L153Q/Y190P variant and methyl methacrylate complex
分子名称: 3-alpha-(Or 20-beta)-hydroxysteroid dehydrogenase, MAGNESIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
著者Cui, J, Huang, X, Wang, B, Zhao, H, Zhou, J.
登録日2021-04-02
公開日2022-05-11
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.80000663 Å)
主引用文献Photoinduced chemomimetic biocatalysis for enantioselective intermolecular radical conjugate addition
Nat Catal, 2022
7EJH
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BU of 7ejh by Molmil
Crystal structure of KRED mutant-F147L/L153Q/Y190P/L199A/M205F/M206F and 2-hydroxyisoindoline-1,3-dione complex
分子名称: 2-oxidanylisoindole-1,3-dione, 3-alpha-(Or 20-beta)-hydroxysteroid dehydrogenase, MAGNESIUM ION, ...
著者Cui, J, Huang, X, Wang, B, Zhao, H, Zhou, J.
登録日2021-04-02
公開日2022-05-11
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.72883928 Å)
主引用文献Photoinduced chemomimetic biocatalysis for enantioselective intermolecular radical conjugate addition
Nat Catal, 2022
7CFN
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BU of 7cfn by Molmil
Cryo-EM structure of the INT-777-bound GPBAR-Gs complex
分子名称: (2S,4R)-4-[(3R,5S,6R,7R,8R,9S,10S,12S,13R,14S,17R)-6-ethyl-10,13-dimethyl-3,7,12-tris(oxidanyl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methyl-pentanoic acid, CHOLESTEROL, G-protein coupled bile acid receptor 1, ...
著者Yang, F, Mao, C, Guo, L, Lin, J, Ming, Q, Xiao, P, Wu, X, Shen, Q, Guo, S, Shen, D, Lu, R, Zhang, L, Huang, S, Ping, Y, Zhang, C, Ma, C, Zhang, K, Liang, X, Shen, Y, Nan, F, Yi, F, Luca, V, Zhou, J, Jiang, C, Sun, J, Xie, X, Yu, X, Zhang, Y.
登録日2020-06-27
公開日2020-09-09
最終更新日2021-04-07
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structural basis of GPBAR activation and bile acid recognition.
Nature, 587, 2020
7CFM
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Cryo-EM structure of the P395-bound GPBAR-Gs complex
分子名称: 2-(ethylamino)-6-[3-(4-propan-2-ylphenyl)propanoyl]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-4-carboxamide, CHOLESTEROL, G-protein coupled bile acid receptor 1, ...
著者Yang, F, Mao, C, Guo, L, Lin, J, Ming, Q, Xiao, P, Wu, X, Shen, Q, Guo, S, Shen, D, Lu, R, Zhang, L, Huang, S, Ping, Y, Zhang, C, Ma, C, Zhang, K, Liang, X, Shen, Y, Nan, F, Yi, F, Luca, V, Zhou, J, Jiang, C, Sun, J, Xie, X, Yu, X, Zhang, Y.
登録日2020-06-27
公開日2020-09-09
最終更新日2020-12-02
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structural basis of GPBAR activation and bile acid recognition.
Nature, 587, 2020
7EZG
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BU of 7ezg by Molmil
The structure of the human METTL6 enzyme in complex with SAH
分子名称: S-ADENOSYL-L-HOMOCYSTEINE, tRNA N(3)-methylcytidine methyltransferase METTL6
著者Xie, W, Chen, R, Zhou, J, Liu, L.
登録日2021-06-01
公開日2022-01-12
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of human METTL6, the m 3 C methyltransferase.
Commun Biol, 4, 2021
7EA9
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Crystal Structure of human lysyl-tRNA synthetase Y145H mutant
分子名称: 5'-O-[(L-LYSYLAMINO)SULFONYL]ADENOSINE, GLYCEROL, Lysine--tRNA ligase
著者Wu, S, Hei, Z, Zheng, L, Zhou, J, Liu, Z, Wang, J, Fang, P.
登録日2021-03-06
公開日2021-03-31
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural analyses of a human lysyl-tRNA synthetase mutant associated with autosomal recessive nonsyndromic hearing impairment.
Biochem.Biophys.Res.Commun., 554, 2021
7E2M
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Crystal structure of the RWD domain of human GCN2 - 2
分子名称: eIF-2-alpha kinase GCN2
著者Hei, Z, Zhou, J, Liu, Z, Wang, J, Fang, P.
登録日2021-02-05
公開日2021-03-17
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Crystal structures reveal a novel dimer of the RWD domain of human general control nonderepressible 2.
Biochem.Biophys.Res.Commun., 549, 2021
7E2K
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Crystal structure of the RWD domain of human GCN2 - 1
分子名称: eIF-2-alpha kinase GCN2
著者Hei, Z, Zhou, J, Liu, Z, Wang, J, Fang, P.
登録日2021-02-05
公開日2021-03-17
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.041 Å)
主引用文献Crystal structures reveal a novel dimer of the RWD domain of human general control nonderepressible 2.
Biochem.Biophys.Res.Commun., 549, 2021
7CVN
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The N-arylsulfonyl-indole-2-carboxamide-based inhibitors against fructose-1,6-bisphosphatase
分子名称: 1,6-di-O-phosphono-beta-D-fructofuranose, 4-(3-acetamidophenyl)-N-(4-methoxyphenyl)sulfonyl-7-nitro-1H-indole-2-carboxamide, Fructose-1,6-bisphosphatase 1
著者Wang, X, Zhou, J, Xu, B.
登録日2020-08-26
公開日2020-09-23
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Design,synthesis,biological evaluation and binding mode analysis of 7-nitro-indole-N-acylarylsulfonamide-based fructose-1,6-bisphosphatase inhibitors
Chinese journal of medicinal chemistry, 30, 2020
7XP9
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Phytophthora infesfans RxLR effector AVRvnt1
分子名称: RxLR effector protein Avr-vnt11
著者Xing, W, Hu, Q, Zhou, J, Yao, D.
登録日2022-05-04
公開日2023-06-07
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Chloroplast Protein GLYK Hijacked by Phytophthora Infestans Effector AVRvnt1 in Cytoplasm to Activate NLR
To Be Published
7XPC
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Complex structure of D-glycerate-3-kinase(GLYK) and AVRvnt1
分子名称: D-glycerate-3-kinase (GLYK), RxLR effector protein Avr-vnt11
著者Hu, Q, Zhou, J, Yao, D, Xing, W.
登録日2022-05-04
公開日2023-06-07
実験手法X-RAY DIFFRACTION (3.31 Å)
主引用文献Chloroplast Protein GLYK Hijacked by Phytophthora Infestans Effector AVRvnt1 in Cytoplasm to Activate NLR
To Be Published
7VA1
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Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with GDD-04-35
分子名称: 4-[(3-ethanoylphenyl)sulfamoyl]-~{N}-[4-(3-fluorophenyl)-1,3-thiazol-2-yl]benzamide, D-3-phosphoglycerate dehydrogenase
著者Cen, Y, Gao, D, Zhou, J, Tian, P.
登録日2021-08-27
公開日2023-03-08
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.74 Å)
主引用文献Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with GDD-04-35
To Be Published
7EEY
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The structure of the N-terminal doamin of the Schizosaccharomyces pombe Tad2 adenosine deaminase
分子名称: SULFATE ION, tRNA-specific adenosine deaminase subunit tad2
著者Xie, W, Liu, X, Zhou, J.
登録日2021-03-19
公開日2022-03-23
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Functional and structural investigation of N-terminal domain of the SpTad2/3 heterodimeric tRNA deaminase.
Comput Struct Biotechnol J, 19, 2021

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