6IX7

The structure of LepI C52A in complex with SAH and substrate analogue

Summary for 6IX7

Entry DOI	10.2210/pdb6ix7/pdb
Descriptor	O-methyltransferase lepI, S-ADENOSYL-L-HOMOCYSTEINE, 4-hydroxy-3-[(2S,6E,8E)-2-methyldeca-6,8-dienoyl]-5-phenylpyridin-2(1H)-one, ... (7 entities in total)
Functional Keywords	leporin, sam, o-methyltransferase, pericyclase, biosynthetic protein
Biological source	Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
Total number of polymer chains	2
Total formula weight	93057.31
Authors	Cai, Y.,Ohashi, M.,Hai, Y.,Tang, Y.,Zhou, J. (deposition date: 2018-12-09, release date: 2019-07-17, Last modification date: 2023-11-22)
Primary citation	Cai, Y.,Hai, Y.,Ohashi, M.,Jamieson, C.S.,Garcia-Borras, M.,Houk, K.N.,Zhou, J.,Tang, Y. Structural basis for stereoselective dehydration and hydrogen-bonding catalysis by the SAM-dependent pericyclase LepI. Nat.Chem., 11:812-820, 2019 Cited by PubMed: 31332284 DOI: 10.1038/s41557-019-0294-x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.835 Å)

Structure validation