7CVN

The N-arylsulfonyl-indole-2-carboxamide-based inhibitors against fructose-1,6-bisphosphatase

Summary for 7CVN

• Entry DOI: 10.2210/pdb7cvn/pdb
• Descriptor: Fructose-1,6-bisphosphatase 1, 4-(3-acetamidophenyl)-N-(4-methoxyphenyl)sulfonyl-7-nitro-1H-indole-2-carboxamide, 1,6-di-O-phosphono-beta-D-fructofuranose, ... (4 entities in total)
• Functional Keywords: fructose-1, 6-bisphosphatase, n-arylsulfonyl-indole-2-carboxamide, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 150944.21

Authors

Wang, X.,Zhou, J.,Xu, B. (deposition date: 2020-08-26, release date: 2020-09-23, Last modification date: 2023-11-29)

• Primary citation: Bie, J.,Wang, X.,Liu, S.,Zhou, J.,Liu, Q.,Shen, Z.,Xu, B.; Design,synthesis,biological evaluation and binding mode analysis of 7-nitro-indole-N-acylarylsulfonamide-based fructose-1,6-bisphosphatase inhibitors; Chinese journal of medicinal chemistry, 30:713-724, 2020; DOI: 10.14142/j.cnki.cn21-1313/r.2020.12.001

Experimental method

X-RAY DIFFRACTION (2.75 Å)