5WRQ

Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor

Summary for 5WRQ

• Entry DOI: 10.2210/pdb5wrq/pdb
• Related: 5WRY 5WRZ 5WS0 5WS1
• Descriptor: Poly [ADP-ribose] polymerase 1, 5-[[2,4-bis(oxidanylidene)quinazolin-1-yl]methyl]-2-fluoranyl-N-[(3R)-1-(3-methylbutyl)pyrrolidin-3-yl]benzamide (2 entities in total)
• Functional Keywords: inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus: P09874
• Total number of polymer chains: 2
• Total formula weight: 79781.34

Authors

Cao, R.,Wang, Y.L.,Zhou, J.,Huang, N.,Xu, B.L. (deposition date: 2016-12-03, release date: 2017-01-25, Last modification date: 2024-03-20)

• Primary citation: Cao, R.,Wang, Y.L.,Zhou, J.,Huang, N.,Xu, B.L.; Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.65 Å)