6LJG
| Crassostrea gigas ferritin mutant-D119G | 分子名称: | FE (III) ION, Ferritin | 著者 | Li, H, Zang, J, Tan, X, Wang, Z, Du, M. | 登録日 | 2019-12-15 | 公開日 | 2020-12-16 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.799 Å) | 主引用文献 | Crassostrea gigas ferritin mutant-D119G To Be Published
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5C6H
| Mcl-1 complexed with Mule | 分子名称: | Induced myeloid leukemia cell differentiation protein Mcl-1, Mule BH3 peptide from E3 ubiquitin-protein ligase HUWE1 | 著者 | Song, T, Wang, Z, Ji, F, Chai, G, Liu, Y, Li, X, Li, Z, Fan, Y, Zhang, Z. | 登録日 | 2015-06-23 | 公開日 | 2016-08-03 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structure of Mcl-1 complexed with Mule at 2.05 Angstroms resolution To Be Published
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5JMT
| Crystal structure of Zika virus NS3 helicase | 分子名称: | NS3 helicase | 著者 | Tian, H, Ji, X, Yang, X, Xie, W, Yang, K, Chen, C, Wu, C, Chi, H, Mu, Z, Wang, Z, Yang, H. | 登録日 | 2016-04-29 | 公開日 | 2016-05-25 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.796 Å) | 主引用文献 | The crystal structure of Zika virus helicase: basis for antiviral drug design Protein Cell, 7, 2016
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2AX1
| Hepatitis C Virus NS5b RNA Polymerase in complex with a covalent inhibitor (5ee) | 分子名称: | 5R-(3,4-DICHLOROPHENYLMETHYL)-3-(2-THIOPHENESULFONYLAMINO)-4-OXO-2-THIONOTHIAZOLIDINE, Genome polyprotein, SULFATE ION | 著者 | Powers, J.P, Piper, D.E, Li, Y, Mayorga, V, Anzola, J, Chen, J.M, Jaen, J.C, Lee, G, Liu, J, Peterson, M.G, Tonn, G.R, Ye, Q, Walker, N.P, Wang, Z. | 登録日 | 2005-09-02 | 公開日 | 2006-01-24 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | SAR and Mode of Action of Novel Non-Nucleoside Inhibitors of Hepatitis C NS5b RNA Polymerase. J.Med.Chem., 49, 2006
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2AX0
| Hepatitis C Virus NS5b RNA Polymerase in complex with a covalent inhibitor (5x) | 分子名称: | 5R-(2E-METHYL-3-PHENYL-ALLYL)-3-(BENZENESULFONYLAMINO)-4-OXO-2-THIONOTHIAZOLIDINE, Genome polyprotein, SULFATE ION | 著者 | Powers, J.P, Piper, D.E, Li, Y, Mayorga, V, Anzola, J, Chen, J.M, Jaen, J.C, Lee, G, Liu, J, Peterson, M.G, Tonn, G.R, Ye, Q, Walker, N.P, Wang, Z. | 登録日 | 2005-09-02 | 公開日 | 2006-01-24 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | SAR and Mode of Action of Novel Non-Nucleoside Inhibitors of Hepatitis C NS5b RNA Polymerase. J.Med.Chem., 49, 2006
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2AWZ
| Hepatitis C Virus NS5b RNA Polymerase in complex with a covalent inhibitor (5h) | 分子名称: | 5R-(4-BROMOPHENYLMETHYL)-3-(BENZENESULFONYLAMINO)-4-OXO-2-THIONOTHIAZOLIDINE, Genome polyprotein, SULFATE ION | 著者 | Powers, J.P, Piper, D.E, Li, Y, Mayorga, V, Anzola, J, Chen, J.M, Jaen, J.C, Lee, G, Liu, J, Peterson, M.G, Tonn, G.R, Ye, Q, Walker, N.P, Wang, Z. | 登録日 | 2005-09-02 | 公開日 | 2006-01-24 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | SAR and Mode of Action of Novel Non-Nucleoside Inhibitors of Hepatitis C NS5b RNA Polymerase. J.Med.Chem., 49, 2006
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7XS8
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7XSA
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7XSB
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3FXV
| Identification of an N-oxide pyridine GW4064 analogue as a potent FXR agonist | 分子名称: | 12-meric peptide from Nuclear receptor coactivator 1, 6-(4-{[3-(3,5-dichloropyridin-4-yl)-5-(1-methylethyl)isoxazol-4-yl]methoxy}-2-methylphenyl)-1-methyl-1H-indole-3-carbox ylic acid, NR1H4 protein | 著者 | Feng, S, Yang, M, He, Y, Chen, L, Zhang, Z, Wang, Z, Hong, D, Richter, H, Benson, G.M, Bleicher, K, Grether, U, Martin, R, Plancher, J.-M, Kuhn, B, Rudolph, M.G. | 登録日 | 2009-01-21 | 公開日 | 2009-04-14 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | 主引用文献 | Identification of an N-oxide pyridine GW4064 analog as a potent FXR agonist Bioorg.Med.Chem.Lett., 19, 2009
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7XN4
| Cryo-EM structure of CopC-CaM-caspase-3 with NAD+ | 分子名称: | Arginine ADP-riboxanase CopC, Calmodulin-1, Caspase-3, ... | 著者 | Zhang, K, Peng, T, Tao, X.Y, Tian, M, Li, Y.X, Wang, Z, Ma, S.F, Hu, S.F, Pan, X, Xue, J, Luo, J.W, Wu, Q.L, Fu, Y, Li, S. | 登録日 | 2022-04-28 | 公開日 | 2022-12-14 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.35 Å) | 主引用文献 | Structural insights into caspase ADPR deacylization catalyzed by a bacterial effector and host calmodulin. Mol.Cell, 82, 2022
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7XN5
| Cryo-EM structure of CopC-CaM-caspase-3 with ADPR | 分子名称: | ADENOSINE-5-DIPHOSPHORIBOSE, Arginine ADP-riboxanase CopC, Calmodulin-1, ... | 著者 | Zhang, K, Peng, T, Tao, X.Y, Tian, M, Li, Y.X, Wang, Z, Ma, S.F, Hu, S.F, Pan, X, Xue, J, Luo, J.W, Wu, Q.L, Fu, Y, Li, S. | 登録日 | 2022-04-28 | 公開日 | 2022-12-14 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.18 Å) | 主引用文献 | Structural insights into caspase ADPR deacylization catalyzed by a bacterial effector and host calmodulin. Mol.Cell, 82, 2022
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1TIO
| HIGH PACKING DENSITY FORM OF BOVINE BETA-TRYPSIN IN CYCLOHEXANE | 分子名称: | BENZAMIDINE, CALCIUM ION, CYCLOHEXANE, ... | 著者 | Huang, Q, Zhu, G, Wang, Z, Tang, Q. | 登録日 | 1998-09-17 | 公開日 | 1998-09-23 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | X-ray studies on two forms of bovine beta-trypsin crystals in neat cyclohexane. Biochim.Biophys.Acta, 1429, 1998
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7XN6
| Cryo-EM structure of CopC-CaM-caspase-3 with ADPR-deacylization | 分子名称: | Arginine ADP-riboxanase CopC, Calmodulin-1, Caspase-3, ... | 著者 | Zhang, K, Peng, T, Tao, X.Y, Tian, M, Li, Y.X, Wang, Z, Ma, S.F, Hu, S.F, Pan, X, Xue, J, Luo, J.W, Wu, Q.L, Fu, Y, Li, S. | 登録日 | 2022-04-28 | 公開日 | 2022-12-14 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.45 Å) | 主引用文献 | Structural insights into caspase ADPR deacylization catalyzed by a bacterial effector and host calmodulin. Mol.Cell, 82, 2022
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5GTX
| Crystal structure of mutated buckwheat glutaredoxin | 分子名称: | buckwheat glutaredoxin | 著者 | Zhang, X, Wang, W, Zhao, Y, Wang, Z, Wang, H. | 登録日 | 2016-08-23 | 公開日 | 2017-07-05 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | 主引用文献 | Structural insights into the binding of buckwheat glutaredoxin with GSH and regulation of its catalytic activity J. Inorg. Biochem., 173, 2017
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1SEK
| THE STRUCTURE OF ACTIVE SERPIN K FROM MANDUCA SEXTA AND A MODEL FOR SERPIN-PROTEASE COMPLEX FORMATION | 分子名称: | SERPIN K | 著者 | Li, J, Wang, Z, Canagarajah, B, Jiang, H, Kanost, M, Goldsmith, E.J. | 登録日 | 1998-03-06 | 公開日 | 1999-03-23 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | The structure of active serpin 1K from Manduca sexta. Structure Fold.Des., 7, 1999
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6ITM
| Crystal structure of FXR in complex with agonist XJ034 | 分子名称: | 1-adamantyl-[4-(5-chloranyl-2-methyl-phenyl)piperazin-1-yl]methanone, Bile acid receptor, HD3 Peptide from Nuclear receptor coactivator 1 | 著者 | Zhang, H, Wang, Z. | 登録日 | 2018-11-23 | 公開日 | 2019-11-27 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Pose Filter-Based Ensemble Learning Enables Discovery of Orally Active, Nonsteroidal Farnesoid X Receptor Agonists. J.Chem.Inf.Model., 60, 2020
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8JQ9
| Novel Anti-phage System | 分子名称: | Endonuclease GajA | 著者 | Li, J, Wang, Z, Wang, L. | 登録日 | 2023-06-13 | 公開日 | 2024-02-28 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (2.66 Å) | 主引用文献 | Structures and activation mechanism of the Gabija anti-phage system. Nature, 629, 2024
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8JQB
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8JQC
| Novel Anti-phage System | 分子名称: | Endonuclease GajA, Gabija protein GajB | 著者 | Li, J, Wang, Z, Wang, L. | 登録日 | 2023-06-13 | 公開日 | 2024-02-28 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.39 Å) | 主引用文献 | Structures and activation mechanism of the Gabija anti-phage system. Nature, 629, 2024
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5UJV
| Crystal structure of FePYR1 in complex with abscisic acid | 分子名称: | (2Z,4E)-5-[(1S)-1-hydroxy-2,6,6-trimethyl-4-oxocyclohex-2-en-1-yl]-3-methylpenta-2,4-dienoic acid, PYR1 | 著者 | Ren, Z, Wang, Z, Zhou, X.E, Hong, Y, Cao, M, Chan, Z, Liu, X, Shi, H, Xu, H.E, Zhu, J.-K. | 登録日 | 2017-01-19 | 公開日 | 2017-11-08 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structure determination and activity manipulation of the turfgrass ABA receptor FePYR1. Sci Rep, 7, 2017
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4KFO
| Structure-Based Discovery of Novel Amide-Containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors | 分子名称: | 1,2-ETHANEDIOL, N-{4-[(3,5-difluorophenyl)sulfonyl]benzyl}imidazo[1,2-a]pyridine-6-carboxamide, Nicotinamide phosphoribosyltransferase, ... | 著者 | Zheng, X, Bauer, P, Baumeister, T, Buckmelter, A.J, Caligiuri, M, Clodfelter, K.H, Han, B, Ho, Y, Kley, N, Lin, J, Reynolds, D.J, Sharma, G, Smith, C.C, Wang, Z, Dragovich, P.S, Gunzner-Tosteb, J, Liederer, B.M, Ly, J, O'Brien, T, Oh, A, Wang, L, Wang, W, Xiao, Y, Zak, M, Zhao, G, Yuen, P, Bair, K.W. | 登録日 | 2013-04-27 | 公開日 | 2013-05-08 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (nampt) inhibitors. J.Med.Chem., 56, 2013
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5VT2
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4KFN
| Structure-Based Discovery of Novel Amide-Containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors | 分子名称: | 1,2-ETHANEDIOL, N-[4-(piperidin-1-ylsulfonyl)benzyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide, Nicotinamide phosphoribosyltransferase, ... | 著者 | Zheng, X, Bauer, P, Baumeister, T, Buckmelter, A.J, Caligiuri, M, Clodfelter, K.H, Han, B, Ho, Y, Kley, N, Lin, J, Reynolds, D.J, Sharma, G, Smith, C.C, Wang, Z, Dragovich, P.S, Gunzner-Toste, J, Liederer, B.M, Ly, J, O'Brien, T, Oh, A, Wang, L, Wang, W, Xiao, Y, Zak, M, Zhao, G, Yuen, P, Bair, K.W. | 登録日 | 2013-04-27 | 公開日 | 2013-05-08 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (nampt) inhibitors. J.Med.Chem., 56, 2013
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4JR5
| Structure-based Identification of Ureas as Novel Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors | 分子名称: | 1,2-ETHANEDIOL, 1-[4-(piperidin-1-ylsulfonyl)phenyl]-3-(pyridin-3-ylmethyl)thiourea, Nicotinamide phosphoribosyltransferase, ... | 著者 | Zheng, X, Bauer, P, Baumeister, T, Buckmelter, A.J, Caligiuri, M, Clodfelter, K.H, Han, B, Ho, Y, Kley, N, Lin, J, Reynolds, D.J, Sharma, G, Smith, C.C, Wang, Z, Dragovich, P.S, Oh, A, Wang, W, Zak, M, Gunzner-Toste, J, Zhao, G, Yuen, P, Bair, K.W. | 登録日 | 2013-03-21 | 公開日 | 2013-05-08 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.906 Å) | 主引用文献 | Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (nampt) inhibitors. J.Med.Chem., 56, 2013
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