4KFO
Structure-Based Discovery of Novel Amide-Containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors
Summary for 4KFO
Entry DOI | 10.2210/pdb4kfo/pdb |
Related | 4JR5 4KFN |
Descriptor | Nicotinamide phosphoribosyltransferase, N-{4-[(3,5-difluorophenyl)sulfonyl]benzyl}imidazo[1,2-a]pyridine-6-carboxamide, PHOSPHATE ION, ... (5 entities in total) |
Functional Keywords | transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm (By similarity): P43490 |
Total number of polymer chains | 2 |
Total formula weight | 115740.16 |
Authors | Zheng, X.,Bauer, P.,Baumeister, T.,Buckmelter, A.J.,Caligiuri, M.,Clodfelter, K.H.,Han, B.,Ho, Y.,Kley, N.,Lin, J.,Reynolds, D.J.,Sharma, G.,Smith, C.C.,Wang, Z.,Dragovich, P.S.,Gunzner-Tosteb, J.,Liederer, B.M.,Ly, J.,O'Brien, T.,Oh, A.,Wang, L.,Wang, W.,Xiao, Y.,Zak, M.,Zhao, G.,Yuen, P.,Bair, K.W. (deposition date: 2013-04-27, release date: 2013-05-08, Last modification date: 2024-02-28) |
Primary citation | Zheng, X.,Bauer, P.,Baumeister, T.,Buckmelter, A.J.,Caligiuri, M.,Clodfelter, K.H.,Han, B.,Ho, Y.C.,Kley, N.,Lin, J.,Reynolds, D.J.,Sharma, G.,Smith, C.C.,Wang, Z.,Dragovich, P.S.,Oh, A.,Wang, W.,Zak, M.,Gunzner-Toste, J.,Zhao, G.,Yuen, P.W.,Bair, K.W. Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (nampt) inhibitors. J.Med.Chem., 56:4921-4937, 2013 Cited by PubMed: 23617784DOI: 10.1021/jm400186h PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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