4KFN

Structure-Based Discovery of Novel Amide-Containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors

Summary for 4KFN

• Entry DOI: 10.2210/pdb4kfn/pdb
• Related: 4JR5 4KFO
• Descriptor: Nicotinamide phosphoribosyltransferase, N-[4-(piperidin-1-ylsulfonyl)benzyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide, PHOSPHATE ION, ... (5 entities in total)
• Functional Keywords: transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm (By similarity): P43490
• Total number of polymer chains: 2
• Total formula weight: 115872.21

Authors

Zheng, X.,Bauer, P.,Baumeister, T.,Buckmelter, A.J.,Caligiuri, M.,Clodfelter, K.H.,Han, B.,Ho, Y.,Kley, N.,Lin, J.,Reynolds, D.J.,Sharma, G.,Smith, C.C.,Wang, Z.,Dragovich, P.S.,Gunzner-Toste, J.,Liederer, B.M.,Ly, J.,O'Brien, T.,Oh, A.,Wang, L.,Wang, W.,Xiao, Y.,Zak, M.,Zhao, G.,Yuen, P.,Bair, K.W. (deposition date: 2013-04-27, release date: 2013-05-08, Last modification date: 2024-02-28)

• Primary citation: Zheng, X.,Bauer, P.,Baumeister, T.,Buckmelter, A.J.,Caligiuri, M.,Clodfelter, K.H.,Han, B.,Ho, Y.C.,Kley, N.,Lin, J.,Reynolds, D.J.,Sharma, G.,Smith, C.C.,Wang, Z.,Dragovich, P.S.,Oh, A.,Wang, W.,Zak, M.,Gunzner-Toste, J.,Zhao, G.,Yuen, P.W.,Bair, K.W.; Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (nampt) inhibitors.; J.Med.Chem., 56:4921-4937, 2013; PubMed: 23617784; DOI: 10.1021/jm400186h

Experimental method

X-RAY DIFFRACTION (1.6 Å)