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6XEY
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BU of 6xey by Molmil
Cryo-EM structure of the SARS-CoV-2 spike glycoprotein bound to Fab 2-4
分子名称: 2-4 Heavy Chain, 2-4 Light Chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Rapp, M, Shapiro, L, Ho, D.D.
登録日2020-06-14
公開日2020-07-22
最終更新日2021-01-27
実験手法ELECTRON MICROSCOPY (3.25 Å)
主引用文献Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike.
Nature, 584, 2020
6XSK
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BU of 6xsk by Molmil
Cryo-EM Structure of Vaccine-Elicited Rhesus Antibody 789-203-3C12 in Complex with Stabilized SI06 (A/Solomon Islands/3/06) Influenza Hemagglutinin Trimer
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 789-203-3C12 Fab Heavy Chain, ...
著者Cerutti, G, Gorman, J, Kwong, P.D, Shapiro, L.
登録日2020-07-15
公開日2021-07-21
最終更新日2023-02-01
実験手法ELECTRON MICROSCOPY (3.85 Å)
主引用文献Co-immunization with hemagglutinin stem immunogens elicits cross-group neutralizing antibodies and broad protection against influenza A viruses.
Immunity, 55, 2022
6YHW
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BU of 6yhw by Molmil
Co-crystals in the P212121 space group, of a beta-cyclodextrin spacered by triazole heptyl from alpha-D-mannose, with FimH lectin at 2.00 A resolution.
分子名称: 2H-1,2,3-TRIAZOL-4-YLMETHANOL, Cycloheptakis-(1-4)-(alpha-D-glucopyranose), FimH, ...
著者de Ruyck, J, Bouckaert, J.
登録日2020-03-31
公開日2020-05-06
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.962 Å)
主引用文献The Antiadhesive Strategy in Crohn's Disease: Orally Active Mannosides to Decolonize Pathogenic Escherichia coli from the Gut.
Chembiochem, 17, 2016
7T4J
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BU of 7t4j by Molmil
Crystal Structure of EGFR_D770_N771insNPG/V948R in complex with TAK-788
分子名称: 1,2-ETHANEDIOL, CITRIC ACID, Epidermal growth factor receptor, ...
著者Skene, R.J, Lane, W, Hu, Y.
登録日2021-12-10
公開日2022-12-07
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Discovery of mobocertinib, a potent, oral inhibitor of EGFR exon 20 insertion mutations in non-small cell lung cancer.
Bioorg.Med.Chem.Lett., 80, 2022
7T4I
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BU of 7t4i by Molmil
Crystal Structure of wild type EGFR in complex with TAK-788
分子名称: Epidermal growth factor receptor, propan-2-yl 2-[[4-[2-(dimethylamino)ethyl-methyl-amino]-2-methoxy-5-(propanoylamino)phenyl]amino]-4-(1-methylindol-3-yl)pyrimidine-5-carboxylate
著者Skene, R.J, Lane, W.
登録日2021-12-10
公開日2022-12-07
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.61 Å)
主引用文献Discovery of mobocertinib, a potent, oral inhibitor of EGFR exon 20 insertion mutations in non-small cell lung cancer.
Bioorg.Med.Chem.Lett., 80, 2022
7L0L
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BU of 7l0l by Molmil
Cryo-EM structure of the VRC316 clinical trial, vaccine-elicited, human antibody 316-310-1B11 in complex with an H2 CAN05 HA trimer
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 316-310-1B11 Heavy Chain, 316-310-1B11 Light Chain, ...
著者Gorman, J, Kwong, P.D.
登録日2020-12-11
公開日2021-11-03
最終更新日2022-03-09
実験手法ELECTRON MICROSCOPY (2.85 Å)
主引用文献A single residue in influenza virus H2 hemagglutinin enhances the breadth of the B cell response elicited by H2 vaccination.
Nat Med, 28, 2022
7MFG
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BU of 7mfg by Molmil
Cryo-EM structure of the VRC310 clinical trial, vaccine-elicited, human antibody 310-030-1D06 Fab in complex with an H1 NC99 HA trimer
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 310-030-1D06 Heavy, 310-030-1D06 Light, ...
著者Gorman, J, Kwong, P.D.
登録日2021-04-09
公開日2021-11-03
最終更新日2022-03-09
実験手法ELECTRON MICROSCOPY (3.87 Å)
主引用文献A single residue in influenza virus H2 hemagglutinin enhances the breadth of the B cell response elicited by H2 vaccination.
Nat Med, 28, 2022
8ANO
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Fucosylated mixed-chirality linear peptide FHP8 bound to the fucose binding lectin LecB PA-IIL from Pseudomonas aeruginosa at 1.3 Angstrom resolution.
分子名称: 3,7-anhydro-2,8-dideoxy-L-glycero-D-gluco-octonic acid, CALCIUM ION, Fucose-binding lectin PA-IIL, ...
著者Personne, H, Stocker, A, Reymond, J.-L.
登録日2022-08-05
公開日2023-05-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.29 Å)
主引用文献To Fold or Not to Fold: Diastereomeric Optimization of an alpha-Helical Antimicrobial Peptide.
J.Med.Chem., 66, 2023
8AOO
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Fucosylated mixed-chirality linear peptide FHP31 bound to the fucose binding lectin LecB PA-IIL from Pseudomonas aeruginosa at 1.2 Angstrom resolution.
分子名称: 3,7-anhydro-2,8-dideoxy-L-glycero-D-gluco-octonic acid, CALCIUM ION, Fucose-binding lectin PA-IIL, ...
著者Personne, H, Stocker, A, Reymond, J.-L.
登録日2022-08-08
公開日2023-05-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.18 Å)
主引用文献To Fold or Not to Fold: Diastereomeric Optimization of an alpha-Helical Antimicrobial Peptide.
J.Med.Chem., 66, 2023
8ANR
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BU of 8anr by Molmil
Fucosylated alternate chirality linear peptide FHP30 bound to the fucose binding lectin LecB PA-IIL from Pseudomonas aeruginosa at 1.6 Angstrom resolution.
分子名称: 3,7-anhydro-2,8-dideoxy-L-glycero-D-gluco-octonic acid, CALCIUM ION, Fucose-binding lectin PA-IIL, ...
著者Personne, H, Stocker, A, Reymond, J.-L.
登録日2022-08-05
公開日2023-05-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.62 Å)
主引用文献To Fold or Not to Fold: Diastereomeric Optimization of an alpha-Helical Antimicrobial Peptide.
J.Med.Chem., 66, 2023
8AN9
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BU of 8an9 by Molmil
Fucosylated mixed-chirality linear peptide FHP5 bound to the fucose binding lectin LecB PA-IIL from Pseudomonas aeruginosa at 1.3 Angstrom resolution.
分子名称: 3,7-anhydro-2,8-dideoxy-L-glycero-D-gluco-octonic acid, CALCIUM ION, Fucose-binding lectin PA-IIL, ...
著者Personne, H, Stocker, A, Reymond, J.-L.
登録日2022-08-04
公開日2023-05-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.273 Å)
主引用文献To Fold or Not to Fold: Diastereomeric Optimization of an alpha-Helical Antimicrobial Peptide.
J.Med.Chem., 66, 2023
8P43
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BU of 8p43 by Molmil
Structure of the MHC class Ib molecule Qa-1b in complex with Q001 peptide
分子名称: Beta-2-microglobulin, H-2 class I histocompatibility antigen, Qa-1b, ...
著者Sala, B.M, Achour, A.
登録日2023-05-19
公開日2024-06-12
実験手法X-RAY DIFFRACTION (2.43 Å)
主引用文献MHC-E is a convergent checkpoint ligand for LILRB1 on macrophages and during inflammation for NKG2A on lymphocytes
To Be Published
8VVB
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BU of 8vvb by Molmil
Influenza antibody L5A7 Fab
分子名称: L5A7 Heavy Chain, L5A7 Light Chain
著者Harris, D.R, Olia, A.S, Kwong, P.D.
登録日2024-01-30
公開日2024-05-22
最終更新日2024-06-26
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献Anti-idiotype isolation of a broad and potent influenza A virus-neutralizing human antibody.
Front Immunol, 15, 2024
8VUE
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BU of 8vue by Molmil
L5A7 Fab bound to Indonesia2005 Hemagglutinin
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1 chain, Hemagglutinin HA2 chain, ...
著者Olia, A.S, Gorman, J, Kwong, P.D.
登録日2024-01-29
公開日2024-05-22
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (3.59 Å)
主引用文献Anti-idiotype isolation of a broad and potent influenza A virus-neutralizing human antibody.
Front Immunol, 15, 2024
8VUZ
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BU of 8vuz by Molmil
L5A7 Fab bound to 28H6E11 anti-idiotype Fab
分子名称: 28H6E11 Fab Heavy Chain, 28H6E11 Fab Light Chain, L5A7 Fab Heavy Chain, ...
著者Olia, A.S, Morano, N.C, Kwong, P.D.
登録日2024-01-30
公開日2024-05-22
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (3.95 Å)
主引用文献Anti-idiotype isolation of a broad and potent influenza A virus-neutralizing human antibody.
Front Immunol, 15, 2024
8TR3
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BU of 8tr3 by Molmil
Cryo-EM structure of HmAb64 scFv in complex with CNE40 SOSIP trimer
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CNE40 SOSIP Envelope glycoprotein gp120, ...
著者Chan, K.-W, Kong, X.P.
登録日2023-08-09
公開日2024-06-19
実験手法ELECTRON MICROSCOPY (3.74 Å)
主引用文献Human CD4-binding site antibody elicited by polyvalent DNA prime-protein boost vaccine neutralizes cross-clade tier-2-HIV strains.
Nat Commun, 15, 2024
6OT1
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BU of 6ot1 by Molmil
Cryo-EM structure of vaccine-elicited antibody 0PV-b.01 in complex with HIV-1 Env BG505 DS-SOSIP and antibodies VRC03 and PGT122
分子名称: 0PV-b.01 heavy, 0PV-b.01 light, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Gorman, J, Kwong, P.D.
登録日2019-05-02
公開日2019-08-07
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization.
Cell, 178, 2019
6OSY
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BU of 6osy by Molmil
Cryo-EM structure of vaccine-elicited antibody 0PV-a.01 in complex with HIV-1 Env BG505 DS-SOSIP and antibodies VRC03 and PGT122
分子名称: 0PV-a.01 Heavy, 0PV-a.01 Light, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Gorman, J, Kwong, P.D.
登録日2019-05-02
公開日2019-07-24
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (4.3 Å)
主引用文献Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization.
Cell, 178, 2019
6WIX
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BU of 6wix by Molmil
Crystal Structure of HIV-1 MI369 RnS-DS.SOSIP Prefusion Env Trimer in Complex with Human Antibodies 3H109L and 35O22 at 3.5 Angstrom
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Lai, Y.-T, Olia, A, Kwong, P.D.
登録日2020-04-10
公開日2020-11-25
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.67 Å)
主引用文献Automated Design by Structure-Based Stabilization and Consensus Repair to Achieve Prefusion-Closed Envelope Trimers in a Wide Variety of HIV Strains.
Cell Rep, 33, 2020
6WWC
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BU of 6wwc by Molmil
Vaccine-elicited mouse FP-targeting neutralizing antibody vFP16.02 with S48K mutation in light chain in complex with HIV fusion peptide (residue 512-519)
分子名称: fusion peptide, vFP16.02 antibody heavy chain, vFP16.02 antibody light chain
著者Xu, K, Wang, Y, Kwong, P.D.
登録日2020-05-09
公開日2021-02-24
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.563 Å)
主引用文献Mutational fitness landscapes reveal genetic and structural improvement pathways for a vaccine-elicited HIV-1 broadly neutralizing antibody.
Proc.Natl.Acad.Sci.USA, 118, 2021
6WX2
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BU of 6wx2 by Molmil
Vaccine-elicited mouse FP-targeting neutralizing antibody vFP16.02 with F60P mutation on light chain in complex with HIV fusion peptide (residue 512-519)
分子名称: fusion peptide, vFP16.02 antibody heavy chain, vFP16.02 antibody light chain
著者Xu, K, Wang, Y, Kwong, P.D.
登録日2020-05-09
公開日2021-03-17
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.39 Å)
主引用文献Mutational fitness landscapes reveal genetic and structural improvement pathways for a vaccine-elicited HIV-1 broadly neutralizing antibody.
Proc.Natl.Acad.Sci.USA, 118, 2021
6WXL
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BU of 6wxl by Molmil
Cryo-EM structure of the VRC315 clinical trial, vaccine-elicited, human antibody 1D12 in complex with an H7 SH13 HA trimer
分子名称: 1D12 Light chain, 1D21 Heavy chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Gorman, J, Kwong, P.D.
登録日2020-05-11
公開日2021-06-09
最終更新日2022-06-22
実験手法ELECTRON MICROSCOPY (2.76 Å)
主引用文献Structure of an influenza group 2-neutralizing antibody targeting the hemagglutinin stem supersite.
Structure, 2022
8G4M
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BU of 8g4m by Molmil
Vaccine-elicited human antibody 2C06 in complex with HIV-1 envelope trimer BG505 DS-SOSIP
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ...
著者Wang, S, Morano, N.C, Shapiro, L, Kwong, P.D.
登録日2023-02-10
公開日2023-07-12
最終更新日2023-07-26
実験手法ELECTRON MICROSCOPY (2.95 Å)
主引用文献HIV-1 neutralizing antibodies elicited in humans by a prefusion-stabilized envelope trimer form a reproducible class targeting fusion peptide.
Cell Rep, 42, 2023
8G4T
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BU of 8g4t by Molmil
Vaccine-elicited human antibody 2C09 in complex with HIV-1 envelope trimer BG505 DS-SOSIP
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein BG505 DS-SOSIP gp120, ...
著者Wang, S, Kwong, P.D.
登録日2023-02-10
公開日2023-07-12
最終更新日2023-07-26
実験手法ELECTRON MICROSCOPY (2.81 Å)
主引用文献HIV-1 neutralizing antibodies elicited in humans by a prefusion-stabilized envelope trimer form a reproducible class targeting fusion peptide.
Cell Rep, 42, 2023
7LD1
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Structure of SARS-CoV-2 S protein in complex with Receptor Binding Domain antibody DH1047
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DH1047 heavy chain, ...
著者Manne, K, Acharya, P.
登録日2021-01-12
公開日2021-01-27
最終更新日2021-08-18
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies.
Cell, 184, 2021

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