7T4J
Crystal Structure of EGFR_D770_N771insNPG/V948R in complex with TAK-788
Summary for 7T4J
Entry DOI | 10.2210/pdb7t4j/pdb |
Descriptor | Epidermal growth factor receptor, propan-2-yl 2-[[4-[2-(dimethylamino)ethyl-methyl-amino]-2-methoxy-5-(propanoylamino)phenyl]amino]-4-(1-methylindol-3-yl)pyrimidine-5-carboxylate, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | kinase, inhibitor, covalent, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 76996.78 |
Authors | Skene, R.J.,Lane, W.,Hu, Y. (deposition date: 2021-12-10, release date: 2022-12-07, Last modification date: 2023-10-25) |
Primary citation | Huang, W.S.,Li, F.,Gong, Y.,Zhang, Y.,Youngsaye, W.,Xu, Y.,Zhu, X.,Greenfield, M.T.,Kohlmann, A.,Taslimi, P.M.,Toms, A.,Zech, S.G.,Zhou, T.,Das, B.,Jang, H.G.,Tugnait, M.,Ye, Y.E.,Gonzalvez, F.,Baker, T.E.,Nadworny, S.,Ning, Y.,Wardwell, S.D.,Zhang, S.,Gould, A.E.,Hu, Y.,Lane, W.,Skene, R.J.,Zou, H.,Clackson, T.,Narasimhan, N.I.,Rivera, V.M.,Dalgarno, D.C.,Shakespeare, W.C. Discovery of mobocertinib, a potent, oral inhibitor of EGFR exon 20 insertion mutations in non-small cell lung cancer. Bioorg.Med.Chem.Lett., 80:129084-129084, 2022 Cited by PubMed: 36423823DOI: 10.1016/j.bmcl.2022.129084 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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