7T4J
Crystal Structure of EGFR_D770_N771insNPG/V948R in complex with TAK-788
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Epidermal growth factor receptor | polymer | 331 | 37687.5 | 2 | UniProt (P00533) Pfam (PF07714) | Homo sapiens (human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 2 | C, E (A, B) | propan-2-yl 2-[[4-[2-(dimethylamino)ethyl-methyl-amino]-2-methoxy-5-(propanoylamino)phenyl]amino]-4-(1-methylindol-3-yl)pyrimidine-5-carboxylate | non-polymer | 587.7 | 2 | Chemie (R28) | |||
| 3 | D (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 4 | F, G (B) | CITRIC ACID | non-polymer | 192.1 | 2 | Chemie (CIT) | |||
| 5 | H, I (A, B) | water | water | 18.0 | 95 | Chemie (HOH) |
Sequence modifications
A, B: 696 - 1025 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Gly 695 | - | expression tag |
| Gly 773 | - | insertion |
| Asn 774 | - | insertion |
| Pro 775 | - | insertion |
| Arg 951 | Val 948 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 75375.0 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1621.7 | |
| All* | Total formula weight | 76996.8 |
