7MFG

Cryo-EM structure of the VRC310 clinical trial, vaccine-elicited, human antibody 310-030-1D06 Fab in complex with an H1 NC99 HA trimer

Summary for 7MFG

• Entry DOI: 10.2210/pdb7mfg/pdb
• Related: 7L0L
• EMDB information: 23816
• Descriptor: Hemagglutinin HA1 chain, Hemagglutinin HA2 chain, 310-030-1D06 Heavy, ... (6 entities in total)
• Functional Keywords: vrc, immune system, vrc310, h1, fab, flu, immune system-viral protein complex, viral protein-immune system complex, viral protein/immune system
• Biological source: Influenza A virus; More
• Total number of polymer chains: 12
• Total formula weight: 265395.95

Authors

Gorman, J.,Kwong, P.D. (deposition date: 2021-04-09, release date: 2021-11-03, Last modification date: 2022-03-09)

• Primary citation: Andrews, S.F.,Raab, J.E.,Gorman, J.,Gillespie, R.A.,Cheung, C.S.F.,Rawi, R.,Cominsky, L.Y.,Boyington, J.C.,Creanga, A.,Shen, C.H.,Harris, D.R.,Olia, A.S.,Nazzari, A.F.,Zhou, T.,Houser, K.V.,Chen, G.L.,Mascola, J.R.,Graham, B.S.,Kanekiyo, M.,Ledgerwood, J.E.,Kwong, P.D.,McDermott, A.B.; A single residue in influenza virus H2 hemagglutinin enhances the breadth of the B cell response elicited by H2 vaccination.; Nat Med, 28:373-382, 2022; PubMed: 35115707; DOI: 10.1038/s41591-021-01636-8

Experimental method

ELECTRON MICROSCOPY (3.87 Å)