7MFG
Cryo-EM structure of the VRC310 clinical trial, vaccine-elicited, human antibody 310-030-1D06 Fab in complex with an H1 NC99 HA trimer
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E, I (A, C, G) | Hemagglutinin HA1 chain | polymer | 326 | 36407.9 | 3 | UniProt (Q6WG00) | Influenza A virus | |
| 2 | B, F, J (B, D, I) | Hemagglutinin HA2 chain | polymer | 222 | 25263.1 | 3 | UniProt (Q289M7) | Influenza A virus | |
| 3 | C, G, K (H, E, J) | 310-030-1D06 Heavy | polymer | 120 | 13000.5 | 3 | Homo sapiens (Human) | ||
| 4 | D, H, L (L, F, K) | 310-030-1D06 Light | polymer | 108 | 11658.9 | 3 | Homo sapiens (Human) | ||
| 5 | M, N, O (M, N, O) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 3 | In PDB GlyTouCan (G15407YE) | |||
| 6 | AA, BA, CA, DA, EA... (C, G, A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 21 | Chemie (NAG) |
Sequence modifications
A, C, G: 11 - 329 (UniProt: Q6WG00)
B, D, I: 1 - 176 (UniProt: Q289M7)
| PDB | External Database | Details |
|---|---|---|
| Cys 30 | Leu 37 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Cys 47 | Gly 390 | conflict |
| Ser 177 | - | expression tag |
| Gly 178 | - | expression tag |
| Arg 179 | - | expression tag |
| Leu 180 | - | expression tag |
| Val 181 | - | expression tag |
| Pro 182 | - | expression tag |
| Arg 183 | - | expression tag |
| Gly 184 | - | expression tag |
| Ser 185 | - | expression tag |
| Pro 186 | - | expression tag |
| Gly 187 | - | expression tag |
| Ser 188 | - | expression tag |
| Gly 189 | - | expression tag |
| Tyr 190 | - | expression tag |
| Ile 191 | - | expression tag |
| Pro 192 | - | expression tag |
| Glu 193 | - | expression tag |
| Ala 194 | - | expression tag |
| Pro 195 | - | expression tag |
| Arg 196 | - | expression tag |
| Asp 197 | - | expression tag |
| Gly 198 | - | expression tag |
| Gln 199 | - | expression tag |
| Ala 200 | - | expression tag |
| Tyr 201 | - | expression tag |
| Val 202 | - | expression tag |
| Arg 203 | - | expression tag |
| Lys 204 | - | expression tag |
| Asp 205 | - | expression tag |
| Gly 206 | - | expression tag |
| Glu 207 | - | expression tag |
| Trp 208 | - | expression tag |
| Val 209 | - | expression tag |
| Leu 210 | - | expression tag |
| Leu 211 | - | expression tag |
| Ser 212 | - | expression tag |
| Thr 213 | - | expression tag |
| Phe 214 | - | expression tag |
| Leu 215 | - | expression tag |
| Gly 216 | - | expression tag |
| His 217 | - | expression tag |
| His 218 | - | expression tag |
| His 219 | - | expression tag |
| His 220 | - | expression tag |
| His 221 | - | expression tag |
| His 222 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 258991.0 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 1759.6 | |
| Non-Polymers* | Number of molecules | 21 |
| Total formula weight | 4645.4 | |
| All* | Total formula weight | 265395.9 |
