6WWC

Vaccine-elicited mouse FP-targeting neutralizing antibody vFP16.02 with S48K mutation in light chain in complex with HIV fusion peptide (residue 512-519)

Summary for 6WWC

• Entry DOI: 10.2210/pdb6wwc/pdb
• Descriptor: vFP16.02 antibody heavy chain, vFP16.02 antibody light chain, fusion peptide, ... (4 entities in total)
• Functional Keywords: hiv, fusion peptide, antibody, immune system-viral protein complex, immune system/viral protein
• Biological source: Mus musculus (Mouse); More
• Total number of polymer chains: 6
• Total formula weight: 95973.11

Authors

Xu, K.,Wang, Y.,Kwong, P.D. (deposition date: 2020-05-09, release date: 2021-02-24, Last modification date: 2023-10-18)

• Primary citation: Madan, B.,Zhang, B.,Xu, K.,Chao, C.W.,O'Dell, S.,Wolfe, J.R.,Chuang, G.Y.,Fahad, A.S.,Geng, H.,Kong, R.,Louder, M.K.,Nguyen, T.D.,Rawi, R.,Schon, A.,Sheng, Z.,Nimrania, R.,Wang, Y.,Zhou, T.,Lin, B.C.,Doria-Rose, N.A.,Shapiro, L.,Kwong, P.D.,DeKosky, B.J.; Mutational fitness landscapes reveal genetic and structural improvement pathways for a vaccine-elicited HIV-1 broadly neutralizing antibody.; Proc.Natl.Acad.Sci.USA, 118:-, 2021; PubMed: 33649208; DOI: 10.1073/pnas.2011653118

Experimental method

X-RAY DIFFRACTION (2.563 Å)