8TR3

Cryo-EM structure of HmAb64 scFv in complex with CNE40 SOSIP trimer

Summary for 8TR3

Entry DOI	10.2210/pdb8tr3/pdb
EMDB information	41569
Descriptor	CNE40 SOSIP Envelope glycoprotein gp120, CNE40 SOSIP Transmembrane protein gp41, HmAb64 Fv heavy chain, ... (6 entities in total)
Functional Keywords	hiv, env, glycoprotein, mab, immune system, immune system-viral protein complex, immune system/viral protein
Biological source	Human immunodeficiency virus 1 More
Total number of polymer chains	12
Total formula weight	301983.21
Authors	Chan, K.-W.,Kong, X.P. (deposition date: 2023-08-09, release date: 2024-06-19)
Primary citation	Wang, S.,Chan, K.W.,Wei, D.,Ma, X.,Liu, S.,Hu, G.,Park, S.,Pan, R.,Gu, Y.,Nazzari, A.F.,Olia, A.S.,Xu, K.,Lin, B.C.,Louder, M.K.,McKee, K.,Doria-Rose, N.A.,Montefiori, D.,Seaman, M.S.,Zhou, T.,Kwong, P.D.,Arthos, J.,Kong, X.P.,Lu, S. Human CD4-binding site antibody elicited by polyvalent DNA prime-protein boost vaccine neutralizes cross-clade tier-2-HIV strains. Nat Commun, 15:4301-4301, 2024 Cited by PubMed: 38773089 DOI: 10.1038/s41467-024-48514-8 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.74 Å)

Structure validation