8TR3
Cryo-EM structure of HmAb64 scFv in complex with CNE40 SOSIP trimer
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C, E | CNE40 SOSIP Envelope glycoprotein gp120 | polymer | 489 | 55018.4 | 3 | UniProt (D7S2E5) Pfam (PF00516) In PDB | Human immunodeficiency virus 1 | |
2 | B, D, F | CNE40 SOSIP Transmembrane protein gp41 | polymer | 153 | 17205.5 | 3 | UniProt (D7S2E5) Pfam (PF00517) In PDB | Human immunodeficiency virus 1 | |
3 | H, I, J | HmAb64 Fv heavy chain | polymer | 124 | 13745.4 | 3 | Homo sapiens | ||
4 | L, M, N | HmAb64 Fv light chain | polymer | 109 | 11852.1 | 3 | Homo sapiens | ||
5 | P, R, c, e, p... | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 6 | In PDB GlyTouCan (G42666HT) | |||
6 | A, C, E | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 27 | Chemie (NAG) |
Sequence modifications
A, C, E: 32 - 511 (UniProt: D7S2E5)
B, D, F: 512 - 664 (UniProt: D7S2E5)
PDB | External Database | Details |
---|---|---|
Cys 501 | Ala 507 | engineered mutation |
Arg 502 | Lys 508 | engineered mutation |
Arg 509 | Glu 515 | engineered mutation |
Arg 510 | Lys 516 | engineered mutation |
Arg 512 | - | insertion |
Arg 513 | - | insertion |
PDB | External Database | Details |
---|---|---|
Pro 559 | Ile 565 | engineered mutation |
Cys 605 | Thr 611 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 12 |
Total formula weight | 293464.2 | |
Branched | Number of molecules | 6 |
Total formula weight | 2546.4 | |
Non-Polymers* | Number of molecules | 27 |
Total formula weight | 5972.6 | |
All* | Total formula weight | 301983.2 |