8G4M

Vaccine-elicited human antibody 2C06 in complex with HIV-1 envelope trimer BG505 DS-SOSIP

Summary for 8G4M

• Entry DOI: 10.2210/pdb8g4m/pdb
• EMDB information: 29725
• Descriptor: Envelope glycoprotein gp120, 2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp41, ... (10 entities in total)
• Functional Keywords: antibody-antigen complex vaccine-elicited antibody fusion peptide strain specific, antiviral protein
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 12
• Total formula weight: 380500.69

Authors

Wang, S.,Morano, N.C.,Shapiro, L.,Kwong, P.D. (deposition date: 2023-02-10, release date: 2023-07-12, Last modification date: 2023-07-26)

• Primary citation: Wang, S.,Matassoli, F.,Zhang, B.,Liu, T.,Shen, C.H.,Bylund, T.,Johnston, T.,Henry, A.R.,Teng, I.T.,Tripathi, P.,Becker, J.E.,Changela, A.,Chaudhary, R.,Cheng, C.,Gaudinski, M.,Gorman, J.,Harris, D.R.,Lee, M.,Morano, N.C.,Novik, L.,O'Dell, S.,Olia, A.S.,Parchment, D.K.,Rawi, R.,Roberts-Torres, J.,Stephens, T.,Tsybovsky, Y.,Wang, D.,Van Wazer, D.J.,Zhou, T.,Doria-Rose, N.A.,Koup, R.A.,Shapiro, L.,Douek, D.C.,McDermott, A.B.,Kwong, P.D.; HIV-1 neutralizing antibodies elicited in humans by a prefusion-stabilized envelope trimer form a reproducible class targeting fusion peptide.; Cell Rep, 42:112755-112755, 2023; PubMed: 37436899; DOI: 10.1016/j.celrep.2023.112755

Experimental method

ELECTRON MICROSCOPY (2.95 Å)