5D22
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4WRL
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![BU of 4wrl by Molmil](/molmil-images/mine/4wrl) | Structure of the human CSF-1:CSF-1R complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Macrophage colony-stimulating factor 1, Macrophage colony-stimulating factor 1 receptor, ... | Authors: | Felix, J, De Munck, S, Elegheert, J, Savvides, S.N. | Deposit date: | 2014-10-24 | Release date: | 2015-08-12 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.802 Å) | Cite: | Structure and Assembly Mechanism of the Signaling Complex Mediated by Human CSF-1. Structure, 23, 2015
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4WRM
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![BU of 4wrm by Molmil](/molmil-images/mine/4wrm) | Structure of the human CSF-1:CSF-1R complex | Descriptor: | Macrophage colony-stimulating factor 1, Macrophage colony-stimulating factor 1 receptor | Authors: | Felix, J, De Munck, S, Elegheert, J, Savvides, S.N. | Deposit date: | 2014-10-24 | Release date: | 2015-08-12 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (6.853 Å) | Cite: | Structure and Assembly Mechanism of the Signaling Complex Mediated by Human CSF-1. Structure, 23, 2015
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6Y3X
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5D28
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6HWN
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![BU of 6hwn by Molmil](/molmil-images/mine/6hwn) | Structure of Thermus thermophilus ClpP in complex with a tripeptide. | Descriptor: | ATP-dependent Clp protease proteolytic subunit, DI(HYDROXYETHYL)ETHER, Unknown tripeptide | Authors: | Felix, J, Schanda, P, Fraga, H, Morlot, C. | Deposit date: | 2018-10-12 | Release date: | 2019-09-18 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Mechanism of the allosteric activation of the ClpP protease machinery by substrates and active-site inhibitors. Sci Adv, 5, 2019
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6HWM
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![BU of 6hwm by Molmil](/molmil-images/mine/6hwm) | Structure of Thermus thermophilus ClpP in complex with bortezomib | Descriptor: | ATP-dependent Clp protease proteolytic subunit, DI(HYDROXYETHYL)ETHER, N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE | Authors: | Felix, J, Schanda, P, Fraga, H, Morlot, C. | Deposit date: | 2018-10-12 | Release date: | 2019-09-18 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Mechanism of the allosteric activation of the ClpP protease machinery by substrates and active-site inhibitors. Sci Adv, 5, 2019
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6YN6
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![BU of 6yn6 by Molmil](/molmil-images/mine/6yn6) | Inducible lysine decarboxylase LdcI stacks, pH 5.7 | Descriptor: | Inducible lysine decarboxylase | Authors: | Felix, J, Jessop, M, Desfosses, A, Effantin, G, Gutsche, I. | Deposit date: | 2020-04-10 | Release date: | 2021-01-13 | Method: | ELECTRON MICROSCOPY (3.28 Å) | Cite: | Supramolecular assembly of the Escherichia coli LdcI upon acid stress. Proc.Natl.Acad.Sci.USA, 118, 2021
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7PQH
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![BU of 7pqh by Molmil](/molmil-images/mine/7pqh) | Cryo-EM structure of Saccharomyces cerevisiae TOROID (TORC1 Organized in Inhibited Domains). | Descriptor: | Serine/threonine-protein kinase TOR2, Target of rapamycin complex 1 subunit KOG1,Target of rapamycin complex 1 subunit Kog1, Target of rapamycin complex subunit LST8 | Authors: | Felix, J, Prouteau, M, Bourgoint, C, Bonadei, L, Desfosses, A, Gabus, C, Sadian, Y, Savvides, S.N, Gutsche, I, Loewith, R. | Deposit date: | 2021-09-17 | Release date: | 2023-01-18 | Last modified: | 2023-03-29 | Method: | ELECTRON MICROSCOPY (3.87 Å) | Cite: | EGOC inhibits TOROID polymerization by structurally activating TORC1. Nat.Struct.Mol.Biol., 30, 2023
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8A8U
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![BU of 8a8u by Molmil](/molmil-images/mine/8a8u) | Mycobacterium tuberculosis ClpC1 hexamer structure | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpC1, Bound polypeptide | Authors: | Felix, J, Fraga, H, Gragera, M, Bueno, T, Weinhaeupl, K. | Deposit date: | 2022-06-24 | Release date: | 2022-10-26 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.62 Å) | Cite: | Structure of the drug target ClpC1 unfoldase in action provides insights on antibiotic mechanism of action. J.Biol.Chem., 298, 2022
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8A8V
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![BU of 8a8v by Molmil](/molmil-images/mine/8a8v) | Mycobacterium tuberculosis ClpC1 hexamer structure bound to the natural product antibiotic Cyclomarin | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpC1, Bound polypeptide | Authors: | Felix, J, Fraga, H, Gragera, M, Bueno, T, Weinhaeupl, K. | Deposit date: | 2022-06-24 | Release date: | 2022-10-26 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.34 Å) | Cite: | Structure of the drug target ClpC1 unfoldase in action provides insights on antibiotic mechanism of action. J.Biol.Chem., 298, 2022
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8A8W
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![BU of 8a8w by Molmil](/molmil-images/mine/8a8w) | Mycobacterium tuberculosis ClpC1 hexamer structure bound to the natural product antibiotic Ecumycin (class 1) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpC1, Bound polypeptide | Authors: | Felix, J, Fraga, H, Gragera, M, Bueno, T, Weinhaeupl, K. | Deposit date: | 2022-06-24 | Release date: | 2022-10-26 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (4.29 Å) | Cite: | Structure of the drug target ClpC1 unfoldase in action provides insights on antibiotic mechanism of action. J.Biol.Chem., 298, 2022
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8ODZ
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![BU of 8odz by Molmil](/molmil-images/mine/8odz) | Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling complex (Class 1). | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1,Death-associated protein kinase 1, Interleukin-12 receptor subunit beta-2,Calmodulin-1, ... | Authors: | Felix, J, Bloch, Y, Savvides, S.N. | Deposit date: | 2023-03-10 | Release date: | 2024-02-07 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23. Nat.Struct.Mol.Biol., 31, 2024
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8OE0
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![BU of 8oe0 by Molmil](/molmil-images/mine/8oe0) | Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling complex (Class 2). | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1,Death-associated protein kinase 1, ... | Authors: | Felix, J, Bloch, Y, Savvides, S.N. | Deposit date: | 2023-03-10 | Release date: | 2024-02-07 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23. Nat.Struct.Mol.Biol., 31, 2024
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8PB1
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![BU of 8pb1 by Molmil](/molmil-images/mine/8pb1) | Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling complex (Class 1), obtained after local refinement. | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1,Death-associated protein kinase 1, Interleukin-12 receptor subunit beta-2,Calmodulin-1, ... | Authors: | Felix, J, Bloch, Y, Savvides, S.N. | Deposit date: | 2023-06-08 | Release date: | 2024-02-07 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23. Nat.Struct.Mol.Biol., 31, 2024
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6JJJ
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7CCH
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![BU of 7cch by Molmil](/molmil-images/mine/7cch) | Acinetobacter baumannii histidine kinase AdeS | Descriptor: | AdeS | Authors: | Wen, Y, Felix, J. | Deposit date: | 2020-06-17 | Release date: | 2021-06-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.848 Å) | Cite: | Proteolysis and multimerization regulate signaling along the two-component regulatory system AdeRS. Iscience, 24, 2021
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6YN5
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![BU of 6yn5 by Molmil](/molmil-images/mine/6yn5) | Inducible lysine decarboxylase LdcI decamer, pH 7.0 | Descriptor: | Inducible lysine decarboxylase | Authors: | Jessop, M, Felix, J, Desfosses, A, Effantin, G, Gutsche, I. | Deposit date: | 2020-04-10 | Release date: | 2021-01-13 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Supramolecular assembly of the Escherichia coli LdcI upon acid stress. Proc.Natl.Acad.Sci.USA, 118, 2021
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8CR6
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![BU of 8cr6 by Molmil](/molmil-images/mine/8cr6) | mouse Interleukin-12 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 subunit alpha, Interleukin-12 subunit beta, ... | Authors: | Merceron, R, Felix, J, Lambert, E, Bloch, Y, Savvides, S.N. | Deposit date: | 2023-03-07 | Release date: | 2024-02-07 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23. Nat.Struct.Mol.Biol., 31, 2024
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8CR5
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![BU of 8cr5 by Molmil](/molmil-images/mine/8cr5) | Murine Interleukin-12 receptor beta 1 domain 1 in complex with murine Interleukin-12 beta. | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1, Interleukin-12 subunit beta, ... | Authors: | Merceron, R, Bloch, Y, Felix, J, Savvides, S.N. | Deposit date: | 2023-03-07 | Release date: | 2024-02-07 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23. Nat.Struct.Mol.Biol., 31, 2024
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4PU8
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![BU of 4pu8 by Molmil](/molmil-images/mine/4pu8) | Shewanella oneidensis Toxin Antitoxin System Antitoxin Protein HipB Resolution 2.35 | Descriptor: | Toxin-antitoxin system antidote transcriptional repressor Xre family | Authors: | Wen, Y, Behiels, E, Felix, J, Elegheert, J, Vergauwen, B, Devreese, B, Savvides, S. | Deposit date: | 2014-03-12 | Release date: | 2014-08-06 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence. Nucleic Acids Res., 42, 2014
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4PU3
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![BU of 4pu3 by Molmil](/molmil-images/mine/4pu3) | Shewanella oneidensis MR-1 Toxin Antitoxin System HipA, HipB and its operator DNA complex (space group P212121) | Descriptor: | Operator DNA, Toxin-antitoxin system antidote transcriptional repressor Xre family, Toxin-antitoxin system toxin HipA family | Authors: | Wen, Y, Behiels, E, Felix, J, Elegheert, J, Vergauwen, B, Devreese, B, Savvides, S. | Deposit date: | 2014-03-12 | Release date: | 2014-08-06 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.39 Å) | Cite: | The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence. Nucleic Acids Res., 42, 2014
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4PU5
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![BU of 4pu5 by Molmil](/molmil-images/mine/4pu5) | Shewanella oneidensis Toxin Antitoxin System Toxin Protein HipA Bound with AMPPNP and Mg | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SODIUM ION, ... | Authors: | Wen, Y, Behiels, E, Felix, J, Elegheert, J, Vergauwen, B, Devreese, B, Savvides, S. | Deposit date: | 2014-03-12 | Release date: | 2014-08-06 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.834 Å) | Cite: | The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence. Nucleic Acids Res., 42, 2014
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4PU4
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![BU of 4pu4 by Molmil](/molmil-images/mine/4pu4) | Shewanella oneidensis MR-1 Toxin Antitoxin System HipA, HipB and its operator DNA complex (space group P21) | Descriptor: | Operator DNA, Toxin-antitoxin system antidote transcriptional repressor Xre family, Toxin-antitoxin system toxin HipA family | Authors: | Wen, Y, Behiels, E, Felix, J, Elegheert, J, Vergauwen, B, Devreese, B, Savvides, S. | Deposit date: | 2014-03-12 | Release date: | 2014-08-06 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.786 Å) | Cite: | The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence. Nucleic Acids Res., 42, 2014
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4PU7
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![BU of 4pu7 by Molmil](/molmil-images/mine/4pu7) | Shewanella oneidensis Toxin Antitoxin System Antitoxin Protein HipB Resolution 1.85 | Descriptor: | Toxin-antitoxin system antidote transcriptional repressor Xre family | Authors: | Wen, Y, Behiels, E, Felix, J, Elegheert, J, Vergauwen, B, Devreese, B, Savvides, S. | Deposit date: | 2014-03-12 | Release date: | 2014-08-06 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence. Nucleic Acids Res., 42, 2014
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