8A8W

Mycobacterium tuberculosis ClpC1 hexamer structure bound to the natural product antibiotic Ecumycin (class 1)

Summary for 8A8W

• Entry DOI: 10.2210/pdb8a8w/pdb
• Related: 8A8U
• EMDB information: 15240 15242
• Descriptor: ATP-dependent Clp protease ATP-binding subunit ClpC1, Bound polypeptide, ADENOSINE-5'-DIPHOSPHATE (3 entities in total)
• Functional Keywords: hexamer, tuberculosis, drug target, protein quality control, chaperone
• Biological source: Mycobacterium tuberculosis; More
• Total number of polymer chains: 7
• Total formula weight: 574969.82

Authors

Felix, J.,Fraga, H.,Gragera, M.,Bueno, T.,Weinhaeupl, K. (deposition date: 2022-06-24, release date: 2022-10-26, Last modification date: 2022-11-23)

• Primary citation: Weinhaupl, K.,Gragera, M.,Bueno-Carrasco, M.T.,Arranz, R.,Krandor, O.,Akopian, T.,Soares, R.,Rubin, E.,Felix, J.,Fraga, H.; Structure of the drug target ClpC1 unfoldase in action provides insights on antibiotic mechanism of action.; J.Biol.Chem., 298:102553-102553, 2022; PubMed: 36208775; DOI: 10.1016/j.jbc.2022.102553

Experimental method

ELECTRON MICROSCOPY (4.29 Å)