7O2W
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![BU of 7o2w by Molmil](/molmil-images/mine/7o2w) | Structure of the C9orf72-SMCR8 complex | Descriptor: | Guanine nucleotide exchange protein SMCR8,Guanine nucleotide exchange protein SMCR8,Maltose/maltodextrin-binding periplasmic protein, Ubiquitin-like protein SMT3,Guanine nucleotide exchange C9orf72 | Authors: | Noerpel, J, Cavadini, S, Schenk, A.D, Graff-Meyer, A, Chao, J, Bhaskar, V. | Deposit date: | 2021-03-31 | Release date: | 2021-07-21 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY | Cite: | Structure of the human C9orf72-SMCR8 complex reveals a multivalent protein interaction architecture. Plos Biol., 19, 2021
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7OKQ
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![BU of 7okq by Molmil](/molmil-images/mine/7okq) | Cryo-EM Structure of the DDB1-DCAF1-CUL4A-RBX1 Complex | Descriptor: | Cullin-4A, DDB1- and CUL4-associated factor 1, DNA damage-binding protein 1, ... | Authors: | Mohamed, W.I, Schenk, A.D, Kempf, G, Cavadini, S, Thoma, N.H. | Deposit date: | 2021-05-18 | Release date: | 2021-10-13 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (8.4 Å) | Cite: | The CRL4 DCAF1 cullin-RING ubiquitin ligase is activated following a switch in oligomerization state. Embo J., 40, 2021
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7Q3E
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![BU of 7q3e by Molmil](/molmil-images/mine/7q3e) | Structure of the mouse CPLANE-RSG1 complex | Descriptor: | Ciliogenesis and planar polarity effector 2, GUANOSINE-5'-TRIPHOSPHATE, Protein fuzzy homolog, ... | Authors: | Langousis, G, Cavadini, S, Kempf, G, Matthias, P. | Deposit date: | 2021-10-27 | Release date: | 2022-04-06 | Last modified: | 2022-04-27 | Method: | ELECTRON MICROSCOPY (3.35 Å) | Cite: | Structure of the ciliogenesis-associated CPLANE complex. Sci Adv, 8, 2022
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7Q3D
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![BU of 7q3d by Molmil](/molmil-images/mine/7q3d) | Structure of the human CPLANE complex | Descriptor: | Protein fuzzy homolog, Protein inturned, WD repeat-containing and planar cell polarity effector protein fritz homolog | Authors: | Langousis, G, Cavadini, S, Kempf, G, Matthias, P. | Deposit date: | 2021-10-27 | Release date: | 2022-04-06 | Last modified: | 2022-04-27 | Method: | ELECTRON MICROSCOPY (3.35 Å) | Cite: | Structure of the ciliogenesis-associated CPLANE complex. Sci Adv, 8, 2022
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8OSL
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![BU of 8osl by Molmil](/molmil-images/mine/8osl) | Cryo-EM structure of CLOCK-BMAL1 bound to the native Por enhancer nucleosome (map 2, additional 3D classification and flexible refinement) | Descriptor: | Basic helix-loop-helix ARNT-like protein 1, Circadian locomoter output cycles protein kaput, DNA (147-MER), ... | Authors: | Michael, A.K, Stoos, L, Kempf, G, Cavadini, S, Thoma, N. | Deposit date: | 2023-04-19 | Release date: | 2023-05-24 | Last modified: | 2023-07-26 | Method: | ELECTRON MICROSCOPY (4.9 Å) | Cite: | Cooperation between bHLH transcription factors and histones for DNA access. Nature, 619, 2023
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8OSK
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![BU of 8osk by Molmil](/molmil-images/mine/8osk) | Cryo-EM structure of CLOCK-BMAL1 bound to a nucleosomal E-box at position SHL+5.8 (composite map) | Descriptor: | Basic helix-loop-helix ARNT-like protein 1, Circadian locomoter output cycles protein kaput, DNA (124-MER), ... | Authors: | Stoos, L, Michael, A.K, Kempf, G, Cavadini, S, Thoma, N.H. | Deposit date: | 2023-04-19 | Release date: | 2023-05-24 | Last modified: | 2023-07-26 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Cooperation between bHLH transcription factors and histones for DNA access. Nature, 619, 2023
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8OSJ
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![BU of 8osj by Molmil](/molmil-images/mine/8osj) | Cryo-EM structure of CLOCK-BMAL1 bound to a nucleosomal E-box at position SHL-6.2 (DNA conformation 1) | Descriptor: | Basic helix-loop-helix ARNT-like protein 1, Circadian locomoter output cycles protein kaput, DNA (124-MER), ... | Authors: | Michael, A.K, Stoos, L, Kempf, G, Cavadini, S, Thoma, N.H. | Deposit date: | 2023-04-19 | Release date: | 2023-05-24 | Last modified: | 2023-07-26 | Method: | ELECTRON MICROSCOPY (6.2 Å) | Cite: | Cooperation between bHLH transcription factors and histones for DNA access. Nature, 619, 2023
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8AJM
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![BU of 8ajm by Molmil](/molmil-images/mine/8ajm) | Structure of human DDB1-DCAF12 in complex with the C-terminus of CCT5 | Descriptor: | DDB1- and CUL4-associated factor 12, DNA damage-binding protein 1, T-complex protein 1 subunit epsilon | Authors: | Pla-Prats, C, Cavadini, S, Kempf, G, Thoma, N.H. | Deposit date: | 2022-07-28 | Release date: | 2022-11-09 | Last modified: | 2023-05-24 | Method: | ELECTRON MICROSCOPY (2.83 Å) | Cite: | Recognition of the CCT5 di-Glu degron by CRL4 DCAF12 is dependent on TRiC assembly. Embo J., 42, 2023
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8AJN
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![BU of 8ajn by Molmil](/molmil-images/mine/8ajn) | Structure of the human DDB1-DCAF12 complex | Descriptor: | DDB1- and CUL4-associated factor 12, DNA damage-binding protein 1 | Authors: | Pla-Prats, C, Cavadini, S, Kempf, G, Thoma, N.H. | Deposit date: | 2022-07-28 | Release date: | 2022-11-09 | Last modified: | 2023-05-24 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Recognition of the CCT5 di-Glu degron by CRL4 DCAF12 is dependent on TRiC assembly. Embo J., 42, 2023
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8AJO
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![BU of 8ajo by Molmil](/molmil-images/mine/8ajo) | Negative-stain electron microscopy structure of DDB1-DCAF12-CCT5 | Descriptor: | DDB1- and CUL4-associated factor 12, DNA damage-binding protein 1, T-complex protein 1 subunit epsilon | Authors: | Pla-Prats, C, Cavadini, S, Kempf, G, Thoma, N.H. | Deposit date: | 2022-07-28 | Release date: | 2022-11-09 | Last modified: | 2023-05-24 | Method: | ELECTRON MICROSCOPY (30.6 Å) | Cite: | Recognition of the CCT5 di-Glu degron by CRL4 DCAF12 is dependent on TRiC assembly. Embo J., 42, 2023
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6Y5E
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![BU of 6y5e by Molmil](/molmil-images/mine/6y5e) | Structure of human cGAS (K394E) bound to the nucleosome (focused refinement of cGAS-NCP subcomplex) | Descriptor: | Cyclic GMP-AMP synthase, DNA (153-MER), Histone H2A type 2-C, ... | Authors: | Pathare, G.R, Cavadini, S, Kempf, G, Thoma, N.H. | Deposit date: | 2020-02-25 | Release date: | 2020-09-23 | Last modified: | 2020-12-09 | Method: | ELECTRON MICROSCOPY (3.15 Å) | Cite: | Structural mechanism of cGAS inhibition by the nucleosome. Nature, 587, 2020
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6YOV
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![BU of 6yov by Molmil](/molmil-images/mine/6yov) | OCT4-SOX2-bound nucleosome - SHL+6 | Descriptor: | DNA (142-MER), Green fluorescent protein,POU domain, class 5, ... | Authors: | Michael, A.K, Kempf, G, Cavadini, S, Bunker, R.D, Thoma, N.H. | Deposit date: | 2020-04-15 | Release date: | 2020-05-06 | Last modified: | 2020-07-08 | Method: | ELECTRON MICROSCOPY (3.42 Å) | Cite: | Mechanisms of OCT4-SOX2 motif readout on nucleosomes. Science, 368, 2020
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6Y5D
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![BU of 6y5d by Molmil](/molmil-images/mine/6y5d) | Structure of human cGAS (K394E) bound to the nucleosome | Descriptor: | Cyclic GMP-AMP synthase, DNA (153-MER), Histone H2A type 2-A, ... | Authors: | Pathare, G.R, Cavadini, S, Kempf, G, Thoma, N.H. | Deposit date: | 2020-02-25 | Release date: | 2020-09-23 | Last modified: | 2020-12-09 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structural mechanism of cGAS inhibition by the nucleosome. Nature, 587, 2020
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8P82
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![BU of 8p82 by Molmil](/molmil-images/mine/8p82) | Cryo-EM structure of dimeric UBR5 | Descriptor: | E3 ubiquitin-protein ligase UBR5, ZINC ION | Authors: | Aguirre, J.D, Kater, L, Kempf, G, Cavadini, S, Thoma, N.H. | Deposit date: | 2023-05-31 | Release date: | 2023-06-14 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.36 Å) | Cite: | UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability. Mol.Cell, 83, 2023
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8P83
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![BU of 8p83 by Molmil](/molmil-images/mine/8p83) | Cryo-EM structure of full-length human UBR5 (homotetramer) | Descriptor: | E3 ubiquitin-protein ligase UBR5 | Authors: | Aguirre, J.D, Kater, L, Kempf, G, Cavadini, S, Thoma, N.H. | Deposit date: | 2023-05-31 | Release date: | 2023-06-14 | Last modified: | 2023-08-16 | Method: | ELECTRON MICROSCOPY (3.87 Å) | Cite: | UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability. Mol.Cell, 83, 2023
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6R90
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![BU of 6r90 by Molmil](/molmil-images/mine/6r90) | Cryo-EM structure of NCP-THF2(+1)-UV-DDB class A | Descriptor: | DNA damage-binding protein 1, DNA damage-binding protein 2, Histone H2A type 1-B/E, ... | Authors: | Matsumoto, S, Cavadini, S, Bunker, R.D, Thoma, N.H. | Deposit date: | 2019-04-02 | Release date: | 2019-06-12 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | DNA damage detection in nucleosomes involves DNA register shifting. Nature, 571, 2019
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6R91
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![BU of 6r91 by Molmil](/molmil-images/mine/6r91) | Cryo-EM structure of NCP_THF2(-3)-UV-DDB | Descriptor: | DNA damage-binding protein 1, DNA damage-binding protein 2, Histone H2A type 1-B/E, ... | Authors: | Matsumoto, S, Cavadini, S, Bunker, R.D, Thoma, N.H. | Deposit date: | 2019-04-02 | Release date: | 2019-06-12 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | DNA damage detection in nucleosomes involves DNA register shifting. Nature, 571, 2019
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6R8Z
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![BU of 6r8z by Molmil](/molmil-images/mine/6r8z) | Cryo-EM structure of NCP_THF2(-1)-UV-DDB | Descriptor: | DNA damage-binding protein 1, DNA damage-binding protein 2, Histone H2A type 1-B/E, ... | Authors: | Matsumoto, S, Cavadini, S, Bunker, R.D, Thoma, N.H. | Deposit date: | 2019-04-02 | Release date: | 2019-06-12 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | DNA damage detection in nucleosomes involves DNA register shifting. Nature, 571, 2019
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6R94
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![BU of 6r94 by Molmil](/molmil-images/mine/6r94) | Cryo-EM structure of NCP_THF2(-3) | Descriptor: | Histone H2A type 1-B/E, Histone H2B type 1-J, Histone H3.1, ... | Authors: | Matsumoto, S, Cavadini, S, Bunker, R.D, Thoma, N.H. | Deposit date: | 2019-04-02 | Release date: | 2019-06-12 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | DNA damage detection in nucleosomes involves DNA register shifting. Nature, 571, 2019
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6R92
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![BU of 6r92 by Molmil](/molmil-images/mine/6r92) | Cryo-EM structure of NCP-THF2(+1)-UV-DDB class B | Descriptor: | DNA damage-binding protein 1,DNA damage-binding protein 1, DNA damage-binding protein 2, Histone H2A type 1-B/E, ... | Authors: | Matsumoto, S, Cavadini, S, Bunker, R.D, Thoma, N.H. | Deposit date: | 2019-04-02 | Release date: | 2019-06-12 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (4.8 Å) | Cite: | DNA damage detection in nucleosomes involves DNA register shifting. Nature, 571, 2019
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6R8Y
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![BU of 6r8y by Molmil](/molmil-images/mine/6r8y) | Cryo-EM structure of NCP-6-4PP(-1)-UV-DDB | Descriptor: | DNA damage-binding protein 1, DNA damage-binding protein 2, Histone H2A type 1-B/E, ... | Authors: | Matsumoto, S, Cavadini, S, Bunker, R.D, Thoma, N.H. | Deposit date: | 2019-04-02 | Release date: | 2019-06-12 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | DNA damage detection in nucleosomes involves DNA register shifting. Nature, 571, 2019
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6R93
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![BU of 6r93 by Molmil](/molmil-images/mine/6r93) | Cryo-EM structure of NCP-6-4PP | Descriptor: | Histone H2A type 1-B/E, Histone H2B type 1-J, Histone H3.1, ... | Authors: | Matsumoto, S, Cavadini, S, Bunker, R.D, Thoma, N.H. | Deposit date: | 2019-04-02 | Release date: | 2019-06-12 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | DNA damage detection in nucleosomes involves DNA register shifting. Nature, 571, 2019
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6Y57
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![BU of 6y57 by Molmil](/molmil-images/mine/6y57) | Structure of human ribosome in hybrid-PRE state | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... | Authors: | Bhaskar, V, Schenk, A.D, Cavadini, S, von Loeffelholz, O, Natchiar, S.K, Klaholz, B.P, Chao, J.A. | Deposit date: | 2020-02-25 | Release date: | 2020-04-15 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Dynamics of uS19 C-Terminal Tail during the Translation Elongation Cycle in Human Ribosomes. Cell Rep, 31, 2020
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8PBA
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![BU of 8pba by Molmil](/molmil-images/mine/8pba) | |
6Y2L
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![BU of 6y2l by Molmil](/molmil-images/mine/6y2l) | Structure of human ribosome in POST state | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, ... | Authors: | Bhaskar, V, Schenk, A.D, Cavadini, S, von Loeffelholz, O, Natchiar, S.K, Klaholz, B.P, Chao, J.A. | Deposit date: | 2020-02-16 | Release date: | 2020-04-15 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Dynamics of uS19 C-Terminal Tail during the Translation Elongation Cycle in Human Ribosomes. Cell Rep, 31, 2020
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