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6Y5E

Structure of human cGAS (K394E) bound to the nucleosome (focused refinement of cGAS-NCP subcomplex)

Summary for 6Y5E
Entry DOI10.2210/pdb6y5e/pdb
EMDB information10695 11005 11006
DescriptorHistone H3.2, Cyclic GMP-AMP synthase, PENTANEDIAL, ... (12 entities in total)
Functional Keywordscgas, sting, nucleosome, innate immunity, cgmp-amp, immune system
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains11
Total formula weight223094.65
Authors
Pathare, G.R.,Cavadini, S.,Kempf, G.,Thoma, N.H. (deposition date: 2020-02-25, release date: 2020-09-23, Last modification date: 2020-12-09)
Primary citationPathare, G.R.,Decout, A.,Gluck, S.,Cavadini, S.,Makasheva, K.,Hovius, R.,Kempf, G.,Weiss, J.,Kozicka, Z.,Guey, B.,Melenec, P.,Fierz, B.,Thoma, N.H.,Ablasser, A.
Structural mechanism of cGAS inhibition by the nucleosome.
Nature, 587:668-672, 2020
Cited by
PubMed: 32911482
DOI: 10.1038/s41586-020-2750-6
PDB entries with the same primary citation
Experimental method
ELECTRON MICROSCOPY (3.15 Å)
Structure validation

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