6Y5E
Structure of human cGAS (K394E) bound to the nucleosome (focused refinement of cGAS-NCP subcomplex)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E | Histone H3.2 | polymer | 96 | 11228.1 | 2 | UniProt (Q71DI3) Pfam (PF00125) In PDB | Homo sapiens (Human) | Histone H3/m,Histone H3/o |
| 2 | B | Histone H4 | polymer | 81 | 9180.7 | 1 | UniProt (P62805) Pfam (PF15511) In PDB | Homo sapiens (Human) | |
| 3 | C | Histone H2A type 2-C | polymer | 107 | 11696.7 | 1 | UniProt (Q16777) Pfam (PF00125) Pfam (PF16211) In PDB | Homo sapiens (Human) | Histone H2A-GL101,Histone H2A/q |
| 4 | D | Histone H2B type 1-K | polymer | 93 | 10320.8 | 1 | UniProt (O60814) Pfam (PF00125) In PDB | Homo sapiens (Human) | H2B K,HIRA-interacting protein 1 |
| 5 | F | Histone H4 | polymer | 83 | 9409.1 | 1 | UniProt (P62805) Pfam (PF15511) In PDB | Homo sapiens (Human) | |
| 6 | G | Histone H2A type 2-C | polymer | 108 | 11825.9 | 1 | UniProt (Q16777) Pfam (PF00125) Pfam (PF16211) In PDB | Homo sapiens (Human) | Histone H2A-GL101,Histone H2A/q |
| 7 | H | Histone H2B type 1-K | polymer | 94 | 10478.0 | 1 | UniProt (O60814) Pfam (PF00125) In PDB | Homo sapiens (Human) | H2B K,HIRA-interacting protein 1 |
| 8 | I | DNA (153-MER) | polymer | 153 | 46998.9 | 1 | Homo sapiens | ||
| 9 | J | DNA (153-MER) | polymer | 153 | 47457.2 | 1 | Homo sapiens | ||
| 10 | K | Cyclic GMP-AMP synthase | polymer | 362 | 42404.8 | 1 | UniProt (Q8N884) Pfam (PF03281) Pfam (PF20266) In PDB | Homo sapiens (Human) | h-cGAS,2'3'-cGAMP synthase,Mab-21 domain-containing protein 1 |
| 11 | A, C, D, E, F... | PENTANEDIAL | non-polymer | 100.1 | 8 | Chemie (PTD) | |||
| 12 | K | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) |
Sequence modifications
A, E: 39 - 134 (UniProt: Q71DI3)
K: 161 - 522 (UniProt: Q8N884)
| PDB | External Database | Details |
|---|---|---|
| Ala 111 | Cys 111 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Glu 394 | Lys 394 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 11 |
| Total formula weight | 222228.3 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 866.3 | |
| All* | Total formula weight | 223094.7 |
