4CDX
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![BU of 4cdx by Molmil](/molmil-images/mine/4cdx) | Crystal structure of human Enterovirus 71 in complex with the uncoating inhibitor GPP12 | Descriptor: | 1-(5-((3'-METHYL-[1,1'-BIPHENYL]-4-YL)OXY)PENTYL)-3-(, SODIUM ION, VP1, ... | Authors: | De Colibus, L, Wang, X, Spyrou, J.A.B, Kelly, J, Ren, J, Grimes, J, Puerstinger, G, Stonehouse, N, Walter, T.S, Hu, Z, Wang, J, Li, X, Peng, W, Rowlands, D, Fry, E.E, Rao, Z, Stuart, D.I. | Deposit date: | 2013-11-07 | Release date: | 2014-02-12 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | More-Powerful Virus Inhibitors from Structure-Based Analysis of Hev71 Capsid-Binding Molecules. Nat.Struct.Mol.Biol., 21, 2014
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7D0G
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![BU of 7d0g by Molmil](/molmil-images/mine/7d0g) | Cryo-EM structure of a pre-catalytic group II intron | Descriptor: | Group II intron-encoded protein LtrA, RNA (714-MER) | Authors: | Liu, N, Dong, X.L, Hu, C.X, Zeng, J.W, Wang, J.W, Wang, J, Wang, H.W, Belfort, M. | Deposit date: | 2020-09-10 | Release date: | 2020-09-30 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (5 Å) | Cite: | Exon and protein positioning in a pre-catalytic group II intron RNP primed for splicing. Nucleic Acids Res., 48, 2020
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4CDW
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![BU of 4cdw by Molmil](/molmil-images/mine/4cdw) | Crystal structure of human Enterovirus 71 in complex with the uncoating inhibitor GPP4 | Descriptor: | 1-[(3S)-5-(4-iodanylphenoxy)-3-methyl-pentyl]-3-pyridin-4-yl-imidazolidin-2-one, SODIUM ION, VP1, ... | Authors: | De Colibus, L, Wang, X, Spyrou, J.A.B, Kelly, J, Ren, J, Grimes, J, Puerstinger, G, Stonehouse, N, Walter, T.S, Hu, Z, Wang, J, Li, X, Peng, W, Rowlands, D, Fry, E.E, Rao, Z, Stuart, D.I. | Deposit date: | 2013-11-06 | Release date: | 2014-02-12 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | More-Powerful Virus Inhibitors from Structure-Based Analysis of Hev71 Capsid-Binding Molecules Nat.Struct.Mol.Biol., 21, 2014
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3IZJ
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![BU of 3izj by Molmil](/molmil-images/mine/3izj) | Mm-cpn rls with ATP and AlFx | Descriptor: | Chaperonin | Authors: | Douglas, N.R, Reissmann, S, Zhang, J, Chen, B, Jakana, J, Kumar, R, Chiu, W, Frydman, J. | Deposit date: | 2010-10-29 | Release date: | 2011-02-02 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (6.9 Å) | Cite: | Dual Action of ATP Hydrolysis Couples Lid Closure to Substrate Release into the Group II Chaperonin Chamber. Cell(Cambridge,Mass.), 144, 2011
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5IRI
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![BU of 5iri by Molmil](/molmil-images/mine/5iri) | |
3MP6
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![BU of 3mp6 by Molmil](/molmil-images/mine/3mp6) | Complex Structure of Sgf29 and dimethylated H3K4 | Descriptor: | H3K4me2 peptide, Maltose-binding periplasmic protein,LINKER,SAGA-associated factor 29, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | Authors: | Li, J, Wu, M, Ruan, J, Zang, J. | Deposit date: | 2010-04-25 | Release date: | 2011-05-04 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.48 Å) | Cite: | Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation Embo J., 30, 2011
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7JJO
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![BU of 7jjo by Molmil](/molmil-images/mine/7jjo) | Structural Basis of the Activation of Heterotrimeric Gs-protein by Isoproterenol-bound Beta1-Adrenergic Receptor | Descriptor: | Beta1-Adrenergic Receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Su, M, Zhu, L, Zhang, Y, Paknejad, N, Dey, R, Huang, J, Lee, M.Y, Williams, D, Jordan, K.D, Eng, E.T, Ernst, O.P, Meyerson, J.R, Hite, R.K, Walz, T, Liu, W, Huang, X.Y. | Deposit date: | 2020-07-27 | Release date: | 2020-09-02 | Last modified: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structural Basis of the Activation of Heterotrimeric Gs-Protein by Isoproterenol-Bound beta 1 -Adrenergic Receptor. Mol.Cell, 80, 2020
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5JPS
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![BU of 5jps by Molmil](/molmil-images/mine/5jps) | |
8HZR
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![BU of 8hzr by Molmil](/molmil-images/mine/8hzr) | Crystal structure of SARS-Cov-2 main protease S46F mutant in complex with PF07321332 | Descriptor: | (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5 | Authors: | Zeng, X.Y, Zhang, J, Li, J. | Deposit date: | 2023-01-09 | Release date: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Crystal structure of SARS-Cov-2 main protease
S46F mutant in complex with PF07321332 To Be Published
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5UN8
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![BU of 5un8 by Molmil](/molmil-images/mine/5un8) | |
5WX8
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![BU of 5wx8 by Molmil](/molmil-images/mine/5wx8) | Human herpesvirus 6A immediate early protein 2 C-terminal domain | Descriptor: | Immediate-early protein 2 | Authors: | Nishimura, M, Wang, J, Wakata, A, Sakamoto, K, Mori, Y. | Deposit date: | 2017-01-06 | Release date: | 2017-08-02 | Last modified: | 2017-12-06 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal Structure of the DNA-Binding Domain of Human Herpesvirus 6A Immediate Early Protein 2. J. Virol., 91, 2017
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8WGF
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![BU of 8wgf by Molmil](/molmil-images/mine/8wgf) | The Crystal Structure of JNK3 from Biortus. | Descriptor: | MAGNESIUM ION, Mitogen-activated protein kinase 10, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | Authors: | Wang, F, Cheng, W, Lv, Z, Ju, C, Wang, J. | Deposit date: | 2023-09-21 | Release date: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | The Crystal Structure of JNK3 from Biortus. To Be Published
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6RPG
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![BU of 6rpg by Molmil](/molmil-images/mine/6rpg) | Structure of human Programmed cell death 1 ligand 1 (PD-L1) with inhibitor | Descriptor: | Programmed cell death 1 ligand 1, ~{N}-[2-[[4-[[3-[3-[[4-[(2-acetamidoethylamino)methyl]-5-[(5-cyanopyridin-3-yl)methoxy]-2-methyl-phenoxy]methyl]-2-methyl-phenyl]-2-methyl-phenyl]methoxy]-2-[(5-cyanopyridin-3-yl)methoxy]-5-methyl-phenyl]methylamino]ethyl]ethanamide | Authors: | Magiera-Mularz, K, Basu, S, Yang, J, Xu, B, Skalniak, L, Musielak, B, Kholodovych, V, Holak, T.A, Hu, L. | Deposit date: | 2019-05-14 | Release date: | 2019-07-24 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Design, Synthesis, Evaluation, and Structural Studies ofC2-Symmetric Small Molecule Inhibitors of Programmed Cell Death-1/Programmed Death-Ligand 1 Protein-Protein Interaction. J.Med.Chem., 62, 2019
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8WGQ
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![BU of 8wgq by Molmil](/molmil-images/mine/8wgq) | The Crystal Structure of L-asparaginase from Biortus. | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, L-asparaginase | Authors: | Wang, F, Cheng, W, Lv, Z, Ju, C, Wang, J. | Deposit date: | 2023-09-22 | Release date: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | The Crystal Structure of L-asparaginase from Biortus. To Be Published
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5G2X
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![BU of 5g2x by Molmil](/molmil-images/mine/5g2x) | Structure a of Group II Intron Complexed with its Reverse Transcriptase | Descriptor: | 5'-R(*CP*AP*CP*AP*UP*CP*CP*AP*UP*AP*AP*CP)-3', GROUP II INTRON, GROUP II INTRON-ENCODED PROTEIN LTRA | Authors: | Qu, G, Kaushal, P.S, Wang, J, Shigematsu, H, Piazza, C.L, Agrawal, R.K, Belfort, M, Wang, H.W. | Deposit date: | 2016-04-16 | Release date: | 2016-05-11 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structure of a Group II Intron in Complex with its Reverse Transcriptase. Nat.Struct.Mol.Biol., 23, 2016
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8KA0
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![BU of 8ka0 by Molmil](/molmil-images/mine/8ka0) | Crystal structure of Vibrio vulnificus RID-dependent transforming NADase domain (RDTND)/calmodulin-binding domain of Rho inactivation domain (RID-CBD) complexed with Ca2+-bound calmodulin and a nicotinamide adenine dinucleotide (NAD+) | Descriptor: | CALCIUM ION, Calmodulin-2, GLYCEROL, ... | Authors: | Lee, Y, Choi, S, Hwang, J, Kim, M.H. | Deposit date: | 2023-08-02 | Release date: | 2024-07-10 | Last modified: | 2024-08-07 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Dissemination of pathogenic bacteria is reinforced by a MARTX toxin effector duet. Nat Commun, 15, 2024
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8KA2
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8K9Z
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![BU of 8k9z by Molmil](/molmil-images/mine/8k9z) | Crystal structure of Vibrio vulnificus RID-dependent transforming NADase domain (RDTND)/calmodulin-binding domain of Rho inactivation domain (RID-CBD) complexed with Ca2+-bound calmodulin | Descriptor: | CALCIUM ION, Calmodulin-2, RDTND-RID CBD | Authors: | Lee, Y, Choi, S, Hwang, J, Kim, M.H. | Deposit date: | 2023-08-02 | Release date: | 2024-07-10 | Last modified: | 2024-08-07 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Dissemination of pathogenic bacteria is reinforced by a MARTX toxin effector duet. Nat Commun, 15, 2024
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8KA1
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![BU of 8ka1 by Molmil](/molmil-images/mine/8ka1) | Crystal structure of Vibrio vulnificus RID-dependent transforming NADase domain (RDTND)/calmodulin-binding domain of Rho inactivation domain (RID-CBD) complexed with Ca2+-free calmodulin | Descriptor: | Calmodulin-2, MAGNESIUM ION, RDTND-RID CBD | Authors: | Lee, Y, Choi, S, Hwang, J, Kim, M.H. | Deposit date: | 2023-08-02 | Release date: | 2024-07-10 | Last modified: | 2024-08-07 | Method: | X-RAY DIFFRACTION (2.82 Å) | Cite: | Dissemination of pathogenic bacteria is reinforced by a MARTX toxin effector duet. Nat Commun, 15, 2024
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4Q0F
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![BU of 4q0f by Molmil](/molmil-images/mine/4q0f) | Crystal Structure of Thermotoga maritima FtsH Periplasmic domain | Descriptor: | ATP-dependent zinc metalloprotease FtsH | Authors: | An, J.Y, Sharif, H, Barrera, F.N, Karabadzhak, A, Kang, G.B, Park, K.J, Sakkiah, S, Lee, K.W, Lee, S, Engelman, D.M, Wang, J, Eom, S.H. | Deposit date: | 2014-04-01 | Release date: | 2015-04-01 | Method: | X-RAY DIFFRACTION (1.948 Å) | Cite: | Structures of periplasmic and transmembrane domains of FtsH suggest a reverse translocon mechanism for protein extraction from membrane To be Published
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7K65
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![BU of 7k65 by Molmil](/molmil-images/mine/7k65) | Hedgehog receptor Patched (PTCH1) in complex with conformation selective nanobody TI23 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-{[(4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta,17beta,25R)-spirost-5-en-3-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranoside, ... | Authors: | Zhang, Y, Bulkley, D.P, Liang, J, Manglik, A, Cheng, Y, Beachy, P.A. | Deposit date: | 2020-09-18 | Release date: | 2021-03-17 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Hedgehog pathway activation through nanobody-mediated conformational blockade of the Patched sterol conduit. Proc.Natl.Acad.Sci.USA, 117, 2020
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8ZH5
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![BU of 8zh5 by Molmil](/molmil-images/mine/8zh5) | |
6IJZ
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![BU of 6ijz by Molmil](/molmil-images/mine/6ijz) | Structure of a plant cation channel | Descriptor: | Calcium permeable stress-gated cation channel 1 | Authors: | Sun, L, Wang, J, Liu, X. | Deposit date: | 2018-10-12 | Release date: | 2018-12-12 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.68 Å) | Cite: | Structure of the hyperosmolality-gated calcium-permeable channel OSCA1.2. Nat Commun, 9, 2018
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3MP8
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![BU of 3mp8 by Molmil](/molmil-images/mine/3mp8) | Crystal structure of Sgf29 tudor domain | Descriptor: | 4-(HYDROXYMETHYL)BENZAMIDINE, ACETIC ACID, GLYCEROL, ... | Authors: | Li, J, Wu, M, Ruan, J, Zang, J. | Deposit date: | 2010-04-26 | Release date: | 2011-05-04 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation Embo J., 30, 2011
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2Z3B
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![BU of 2z3b by Molmil](/molmil-images/mine/2z3b) | Crystal Structure of Bacillus Subtilis CodW, a non-canonical HslV-like peptidase with an impaired catalytic apparatus | Descriptor: | ATP-dependent protease hslV, SODIUM ION | Authors: | Rho, S.H, Park, H.H, Kang, G.B, Lim, Y.J, Kang, M.S, Lim, B.K, Seong, I.S, Chung, C.H, Wang, J, Eom, S.H. | Deposit date: | 2007-06-03 | Release date: | 2008-03-25 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of Bacillus subtilis CodW, a noncanonical HslV-like peptidase with an impaired catalytic apparatus Proteins, 71, 2007
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