5UKR
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6Z1V
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![BU of 6z1v by Molmil](/molmil-images/mine/6z1v) | Structure of the EC2 domain of CD9 in complex with nanobody 4E8 | Descriptor: | 1,2-ETHANEDIOL, ACETIC ACID, CD9 antigen, ... | Authors: | Oosterheert, W, Pearce, N.M, Gros, P. | Deposit date: | 2020-05-14 | Release date: | 2020-09-23 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.33 Å) | Cite: | Implications for tetraspanin-enriched microdomain assembly based on structures of CD9 with EWI-F. Life Sci Alliance, 3, 2020
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5ZFZ
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![BU of 5zfz by Molmil](/molmil-images/mine/5zfz) | Crystal structure of human DUX4 homeodomains bound to A12T DNA mutant | Descriptor: | DNA (5'-D(*CP*CP*AP*CP*TP*AP*AP*CP*CP*TP*AP*TP*TP*CP*AP*CP*AP*CP*C)-3'), DNA (5'-D(*GP*GP*TP*GP*TP*GP*AP*AP*TP*AP*GP*GP*TP*TP*AP*GP*TP*GP*G)-3'), Double homeobox protein 4-like protein 4 | Authors: | Li, Y.Y, Wu, B.X, Gan, J.H. | Deposit date: | 2018-03-07 | Release date: | 2018-10-31 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis for multiple gene regulation by human DUX4. Biochem. Biophys. Res. Commun., 505, 2018
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8WI2
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![BU of 8wi2 by Molmil](/molmil-images/mine/8wi2) | RD-hMRP5-inward open | Descriptor: | ATP-binding cassette sub-family C member 5, CYS-GLN-ASP-ALA-LEU-GLU-THR-ALA-ALA-ARG-ALA-GLU-GLY-LEU-SER-LEU-ASP-ALA-SER | Authors: | Liu, Z.M, Huang, Y. | Deposit date: | 2023-09-24 | Release date: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (4.06 Å) | Cite: | Inhibition and transport mechanisms of the ABC transporter hMRP5. Nat Commun, 15, 2024
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8WI3
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![BU of 8wi3 by Molmil](/molmil-images/mine/8wi3) | ND-hMRP5-inward open | Descriptor: | ATP-binding cassette sub-family C member 5 | Authors: | Liu, Z.M, Huang, Y. | Deposit date: | 2023-09-24 | Release date: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.38 Å) | Cite: | Inhibition and transport mechanisms of the ABC transporter hMRP5. Nat Commun, 15, 2024
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8WI0
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![BU of 8wi0 by Molmil](/molmil-images/mine/8wi0) | wt-hMRP5 inward-open | Descriptor: | ATP-binding cassette sub-family C member 5 | Authors: | Liu, Z.M, Huang, Y. | Deposit date: | 2023-09-24 | Release date: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (2.93 Å) | Cite: | Inhibition and transport mechanisms of the ABC transporter hMRP5. Nat Commun, 15, 2024
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8WI5
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![BU of 8wi5 by Molmil](/molmil-images/mine/8wi5) | M5PI-bound hMRP5 | Descriptor: | ATP-binding cassette sub-family C member 5 | Authors: | Liu, Z.M, Huang, Y. | Deposit date: | 2023-09-24 | Release date: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.46 Å) | Cite: | Inhibition and transport mechanisms of the ABC transporter hMRP5. Nat Commun, 15, 2024
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8WI4
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![BU of 8wi4 by Molmil](/molmil-images/mine/8wi4) | m6-hMRP5 inward open | Descriptor: | ATP-binding cassette sub-family C member 5 | Authors: | Liu, Z.M, Huang, Y. | Deposit date: | 2023-09-24 | Release date: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Inhibition and transport mechanisms of the ABC transporter hMRP5. Nat Commun, 15, 2024
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6ZFM
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![BU of 6zfm by Molmil](/molmil-images/mine/6zfm) | Structure of alpha-Cobratoxin with a peptide inhibitor | Descriptor: | 3-[2-[2-[2-[2-[2-(2-azanylethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propan-1-ol, Alpha-cobratoxin, PENTAETHYLENE GLYCOL, ... | Authors: | Kiontke, S, Kummel, D. | Deposit date: | 2020-06-17 | Release date: | 2020-12-02 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Peptide Inhibitors of the alpha-Cobratoxin-Nicotinic Acetylcholine Receptor Interaction. J.Med.Chem., 63, 2020
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2HAL
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![BU of 2hal by Molmil](/molmil-images/mine/2hal) | An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors | Descriptor: | Hepatitis A Protease 3C, N-ACETYL-LEUCYL-PHENYLALANYL-PHENYLALANYL-GLUTAMATE-FLUOROMETHYLKETONE INHIBITOR, N-[(BENZYLOXY)CARBONYL]-L-ALANINE | Authors: | Yin, J, Cherney, M.M, Bergmann, E.M, James, M.N. | Deposit date: | 2006-06-13 | Release date: | 2006-08-08 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | An Episulfide Cation (Thiiranium Ring) Trapped in the Active Site of HAV 3C Proteinase Inactivated by Peptide-based Ketone Inhibitors. J.Mol.Biol., 361, 2006
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5VAQ
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![BU of 5vaq by Molmil](/molmil-images/mine/5vaq) | Crystal Structure of Beta-Klotho in Complex with FGF21CT | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-klotho, Fibroblast growth factor 21, ... | Authors: | Lee, S, Schlessinger, J. | Deposit date: | 2017-03-27 | Release date: | 2018-01-31 | Last modified: | 2021-03-24 | Method: | X-RAY DIFFRACTION (2.606 Å) | Cite: | Structures of beta-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling. Nature, 553, 2018
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6BHX
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![BU of 6bhx by Molmil](/molmil-images/mine/6bhx) | B. subtilis SsbA with DNA | Descriptor: | DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), Single-stranded DNA-binding protein A | Authors: | Dubiel, K.D, Myers, A.R, Satyshur, K.A, Keck, J.L. | Deposit date: | 2017-10-31 | Release date: | 2018-12-19 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.936 Å) | Cite: | Structural Mechanisms of Cooperative DNA Binding by Bacterial Single-Stranded DNA-Binding Proteins. J. Mol. Biol., 431, 2019
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6LS4
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![BU of 6ls4 by Molmil](/molmil-images/mine/6ls4) | A novel anti-tumor agent S-40 in complex with tubulin | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-[(4-cyclopropylphenyl)sulfonylamino]-4-methyl-N-(pyridin-3-ylmethyl)benzamide, GLYCEROL, ... | Authors: | Du, T, Lin, S, Ji, M, Xue, N, Liu, Y, Zhang, K, Lu, D, Chen, X, Xu, H. | Deposit date: | 2020-01-17 | Release date: | 2021-01-20 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | A novel orally active microtubule destabilizing agent S-40 targets the colchicine-binding site and shows potent antitumor activity. Cancer Lett., 495, 2020
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5KK0
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![BU of 5kk0 by Molmil](/molmil-images/mine/5kk0) | Synechocystis ACO mutant - T136A | Descriptor: | Apocarotenoid-15,15'-oxygenase, CHLORIDE ION, FE (II) ION | Authors: | Sui, X, Kiser, P.D, Palczewski, K. | Deposit date: | 2016-06-20 | Release date: | 2016-07-13 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Utilization of Dioxygen by Carotenoid Cleavage Oxygenases. J.Biol.Chem., 290, 2015
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5ZFW
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![BU of 5zfw by Molmil](/molmil-images/mine/5zfw) | Crystal structure of human DUX4 homeodomains bound to A11G DNA mutant | Descriptor: | DNA (5'-D(*CP*CP*AP*CP*TP*AP*AP*CP*CP*TP*GP*AP*TP*CP*AP*CP*AP*CP*C)-3'), DNA (5'-D(*GP*GP*TP*GP*TP*GP*AP*TP*CP*AP*GP*GP*TP*TP*AP*GP*TP*GP*G)-3'), Double homeobox protein 4-like protein 4 | Authors: | Li, Y.Y, Wu, B.X, Gan, J.H. | Deposit date: | 2018-03-07 | Release date: | 2018-10-31 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.103 Å) | Cite: | Structural basis for multiple gene regulation by human DUX4. Biochem. Biophys. Res. Commun., 505, 2018
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3RKC
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8YLB
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![BU of 8ylb by Molmil](/molmil-images/mine/8ylb) | Cocrystal structures of agonists compound 1 with HsClpP | Descriptor: | 5-[(2-methylphenyl)methyl]-11-(phenylmethyl)-2,5,7,11-tetrazatricyclo[7.4.0.0^{2,6}]trideca-1(9),6-dien-8-one, ATP-dependent Clp protease proteolytic subunit, mitochondrial | Authors: | Zhao, N, Zhu, Y, Bao, R. | Deposit date: | 2024-03-06 | Release date: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Rational Design of a Novel Class of Human ClpP Agonists through a Ring-Opening Strategy with Enhanced Antileukemia Activity. J.Med.Chem., 67, 2024
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8J0K
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![BU of 8j0k by Molmil](/molmil-images/mine/8j0k) | Crystal structure of human TFAP2A in complex with DNA | Descriptor: | DNA (5'-D(*CP*TP*GP*CP*CP*TP*CP*GP*GP*GP*CP*AP*C)-3'), DNA (5'-D(*GP*TP*GP*CP*CP*CP*GP*AP*GP*GP*CP*AP*G)-3'), GLYCEROL, ... | Authors: | Liu, K, Xiao, Y.Q, Li, W.F, Min, J.R. | Deposit date: | 2023-04-11 | Release date: | 2023-07-05 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural basis for specific DNA sequence motif recognition by the TFAP2 transcription factors. Nucleic Acids Res., 51, 2023
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8J0Q
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![BU of 8j0q by Molmil](/molmil-images/mine/8j0q) | Structure of DNA binding domain of human TFAP2B | Descriptor: | GLYCEROL, Transcription factor AP-2-beta | Authors: | Liu, K, Xiao, Y.Q, Li, W.F, Min, J.R. | Deposit date: | 2023-04-11 | Release date: | 2023-07-05 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural basis for specific DNA sequence motif recognition by the TFAP2 transcription factors. Nucleic Acids Res., 51, 2023
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8J0L
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![BU of 8j0l by Molmil](/molmil-images/mine/8j0l) | Structure of DNA binding Domain of Human TFAP2A | Descriptor: | GLYCEROL, Transcription factor AP-2-alpha | Authors: | Liu, K, Xiao, Y.Q, Gan, L.Y, Min, J.R. | Deposit date: | 2023-04-11 | Release date: | 2023-07-05 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Structural basis for specific DNA sequence motif recognition by the TFAP2 transcription factors. Nucleic Acids Res., 51, 2023
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5ZFY
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![BU of 5zfy by Molmil](/molmil-images/mine/5zfy) | Crystal structure of human DUX4 homeodomains bound to A12C DNA mutant | Descriptor: | DNA (5'-D(*CP*CP*AP*CP*TP*AP*AP*CP*CP*TP*AP*CP*TP*CP*AP*CP*AP*CP*C)-3'), DNA (5'-D(*GP*GP*TP*GP*TP*GP*AP*GP*TP*AP*GP*GP*TP*TP*AP*GP*TP*GP*G)-3'), Double homeobox protein 4-like protein 4 | Authors: | Li, Y.Y, Wu, B.X, Gan, J.H. | Deposit date: | 2018-03-07 | Release date: | 2018-10-31 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis for multiple gene regulation by human DUX4. Biochem. Biophys. Res. Commun., 505, 2018
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8J0R
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![BU of 8j0r by Molmil](/molmil-images/mine/8j0r) | Structure of human TFAP2A in complex with DNA | Descriptor: | DI(HYDROXYETHYL)ETHER, DNA (5'-D(*CP*TP*GP*CP*CP*TP*CP*AP*GP*GP*CP*AP*C)-3'), DNA (5'-D(*GP*TP*GP*CP*CP*TP*GP*AP*GP*GP*CP*AP*G)-3'), ... | Authors: | Liu, K, Xiao, Y.Q, Li, W.F, Min, J.R. | Deposit date: | 2023-04-11 | Release date: | 2023-07-05 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural basis for specific DNA sequence motif recognition by the TFAP2 transcription factors. Nucleic Acids Res., 51, 2023
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8XR2
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![BU of 8xr2 by Molmil](/molmil-images/mine/8xr2) | Crystal structure of AKRtyl-apo1 | Descriptor: | Aldo/keto reductase | Authors: | Lin, S, Dai, S, Xiao, Z. | Deposit date: | 2024-01-06 | Release date: | 2024-04-10 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.39 Å) | Cite: | A three-level regulatory mechanism of the aldo-keto reductase subfamily AKR12D. Nat Commun, 15, 2024
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8XR4
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![BU of 8xr4 by Molmil](/molmil-images/mine/8xr4) | Crystal structure of AKRtyl-NADP(H) complex | Descriptor: | Aldo/keto reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Lin, S, Dai, S, Xiao, Z. | Deposit date: | 2024-01-06 | Release date: | 2024-04-10 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | A three-level regulatory mechanism of the aldo-keto reductase subfamily AKR12D. Nat Commun, 15, 2024
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5T8I
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![BU of 5t8i by Molmil](/molmil-images/mine/5t8i) | PI3Kdelta in complex with the inhibitor GS-9901 | Descriptor: | 2,4-diamino-6-{[(S)-[5-chloro-8-fluoro-4-oxo-3-(pyridin-3-yl)-3,4-dihydroquinazolin-2-yl](cyclopropyl)methyl]amino}pyrimidine-5-carbonitrile, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | Authors: | Somoza, J.R, Villasenor, A. | Deposit date: | 2016-09-07 | Release date: | 2016-12-28 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | The Discovery of GS-9901: A Potent, Selective and Metabolically Stable Inhibitor of PI3Kd To Be Published
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