8YLB
Cocrystal structures of agonists compound 1 with HsClpP
This is a non-PDB format compatible entry.
Summary for 8YLB
Entry DOI | 10.2210/pdb8ylb/pdb |
Descriptor | ATP-dependent Clp protease proteolytic subunit, mitochondrial, 5-[(2-methylphenyl)methyl]-11-(phenylmethyl)-2,5,7,11-tetrazatricyclo[7.4.0.0^{2,6}]trideca-1(9),6-dien-8-one (3 entities in total) |
Functional Keywords | homo sapiens casein lysing protease p (hsclpp) acute myeloid leukemia (aml) agonists, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 14 |
Total formula weight | 342710.00 |
Authors | |
Primary citation | Xiang, X.,Dai, Z.,Luo, B.,Zhao, N.,Liu, S.,Sui, J.,Huang, J.,Zhou, Y.,Gu, J.,Zhang, J.,Yang, T.,Bao, R.,Luo, Y. Rational Design of a Novel Class of Human ClpP Agonists through a Ring-Opening Strategy with Enhanced Antileukemia Activity. J.Med.Chem., 67:6769-6792, 2024 Cited by PubMed: 38620134DOI: 10.1021/acs.jmedchem.4c00338 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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