5T8I

PI3Kdelta in complex with the inhibitor GS-9901

Summary for 5T8I

• Entry DOI: 10.2210/pdb5t8i/pdb
• Related: 5T8I
• Descriptor: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, 2,4-diamino-6-{[(S)-[5-chloro-8-fluoro-4-oxo-3-(pyridin-3-yl)-3,4-dihydroquinazolin-2-yl](cyclopropyl)methyl]amino}pyrimidine-5-carbonitrile (2 entities in total)
• Functional Keywords: pi3kdelta phosphatidylinositol-3-kinase pi(3)k, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Mus musculus (Mouse)
• Cellular location: Cytoplasm : O35904
• Total number of polymer chains: 1
• Total formula weight: 108244.49

Authors

Somoza, J.R.,Villasenor, A. (deposition date: 2016-09-07, release date: 2016-12-28, Last modification date: 2024-03-06)

• Primary citation: Patel, L.,Chandrasekhar, J.,Evarts, J.,Forseth, K.,Haran, A.,Ip, C.,Kashishian, A.,Kim, M.,Koditek, D.,Koppenol, S.,Lad, L.,Lepist, E.-I.,McGrath, M.E.,Perreault, S.,Puri, K.,Villasenor, A.,Somoza, J.R.,Steiner, B.,Therrien, J.,Trilberg, J.,Phillips, G.; The Discovery of GS-9901: A Potent, Selective and Metabolically Stable Inhibitor of PI3Kd; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.6 Å)