4OFD
| Crystal Structure of mouse Neph1 D1-D2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Kin of IRRE-like protein 1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Ozkan, E, Garcia, K.C. | Deposit date: | 2014-01-14 | Release date: | 2014-02-19 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.94 Å) | Cite: | Extracellular Architecture of the SYG-1/SYG-2 Adhesion Complex Instructs Synaptogenesis. Cell(Cambridge,Mass.), 156, 2014
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4MQT
| Structure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo and allosteric modulator LY2119620 | Descriptor: | 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide, 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, Muscarinic acetylcholine receptor M2, ... | Authors: | Kruse, A.C, Ring, A.M, Manglik, A, Hu, J, Hu, K, Eitel, K, Huebner, H, Pardon, E, Valant, C, Sexton, P.M, Christopoulos, A, Felder, C.C, Gmeiner, P, Steyaert, J, Weis, W.I, Garcia, K.C, Wess, J, Kobilka, B.K. | Deposit date: | 2013-09-16 | Release date: | 2013-11-27 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | Activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature, 504, 2013
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4MXQ
| 42F3 TCR pCPC5/H-2Ld Complex | Descriptor: | 42F3 alpha VmVh chimera, 42F3 beta VmVh chimera, H-2 class I histocompatibility antigen, ... | Authors: | Birnbaum, M.E, Adams, J.J, Garcia, K.C. | Deposit date: | 2013-09-26 | Release date: | 2015-08-19 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.596 Å) | Cite: | Structural interplay between germline interactions and adaptive recognition determines the bandwidth of TCR-peptide-MHC cross-reactivity. Nat. Immunol., 17, 2016
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4MVB
| 42F3 pCPB7/H-2Ld Complex | Descriptor: | 42F3 alpha VmCh, 42F3 beta VmCh, H-2 class I histocompatibility antigen, ... | Authors: | Birnbaum, M.E, Adams, J.J, Garcia, K.C. | Deposit date: | 2013-09-23 | Release date: | 2015-08-19 | Last modified: | 2018-09-26 | Method: | X-RAY DIFFRACTION (3.088 Å) | Cite: | Structural interplay between germline interactions and adaptive recognition determines the bandwidth of TCR-peptide-MHC cross-reactivity. Nat. Immunol., 17, 2016
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4NHU
| The M33 TCR p3M33l/H-2 Ld Complex | Descriptor: | 2C m33 alpha VmCh chimera, 2C m33 beta VmCh chimera, H-2 class I histocompatibility antigen, ... | Authors: | Birnbaum, M.E, Adams, J.J, Garcia, K.C. | Deposit date: | 2013-11-05 | Release date: | 2015-05-06 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Interrogating TCR Signal Strength and Cross-Reactivity by Yeast Display of pMHC To be Published
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4OFI
| Crystal Structure of Duf (Kirre) D1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Kin of irre, isoform A, ... | Authors: | Ozkan, E, Garcia, K.C. | Deposit date: | 2014-01-14 | Release date: | 2014-02-19 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Extracellular Architecture of the SYG-1/SYG-2 Adhesion Complex Instructs Synaptogenesis. Cell(Cambridge,Mass.), 156, 2014
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4OQW
| Crystal structure of mCardinal far-red fluorescent protein | Descriptor: | Fluorescent protein FP480 | Authors: | Burg, J.S, Chu, J, Lam, A.J, Lin, M.Z, Garcia, K.C. | Deposit date: | 2014-02-10 | Release date: | 2014-03-12 | Last modified: | 2014-05-14 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Non-invasive intravital imaging of cellular differentiation with a bright red-excitable fluorescent protein. Nat.Methods, 11, 2014
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4OF3
| Crystal Structure of SYG-1 D1-D2, Glycosylated | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Protein SYG-1, isoform b, ... | Authors: | Ozkan, E, Garcia, K.C. | Deposit date: | 2014-01-14 | Release date: | 2014-02-19 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Extracellular Architecture of the SYG-1/SYG-2 Adhesion Complex Instructs Synaptogenesis. Cell(Cambridge,Mass.), 156, 2014
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4OFP
| Crystal Structure of SYG-2 D3-D4 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Protein SYG-2 | Authors: | Ozkan, E, Garcia, K.C. | Deposit date: | 2014-01-15 | Release date: | 2014-02-19 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Extracellular Architecture of the SYG-1/SYG-2 Adhesion Complex Instructs Synaptogenesis. Cell(Cambridge,Mass.), 156, 2014
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4OF8
| Crystal Structure of Rst D1-D2 | Descriptor: | GLYCEROL, Irregular chiasm C-roughest protein, SODIUM ION | Authors: | Ozkan, E, Garcia, K.C. | Deposit date: | 2014-01-14 | Release date: | 2014-02-19 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (1.902 Å) | Cite: | Extracellular Architecture of the SYG-1/SYG-2 Adhesion Complex Instructs Synaptogenesis. Cell(Cambridge,Mass.), 156, 2014
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6E3K
| Interferon gamma signalling complex with IFNGR1 and IFNGR2 | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Jude, K.M, Mendoza, J.L, Garcia, K.C. | Deposit date: | 2018-07-14 | Release date: | 2019-02-27 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | Structure of the IFN gamma receptor complex guides design of biased agonists. Nature, 567, 2019
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6E3L
| Interferon gamma signalling complex with IFNGR1 and IFNGR2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CYSTEINE, ... | Authors: | Jude, K.M, Mendoza, J.L, Garcia, K.C. | Deposit date: | 2018-07-14 | Release date: | 2019-02-27 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Structure of the IFN gamma receptor complex guides design of biased agonists. Nature, 567, 2019
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6DG5
| Structure of a de novo designed Interleukin-2/Interleukin-15 mimetic complex with IL-2Rb and IL-2Rg | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common subunit gamma, ... | Authors: | Jude, K.M, Silva, D.-A, Yu, S, Baker, D, Garcia, K.C. | Deposit date: | 2018-05-16 | Release date: | 2019-01-16 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (2.516 Å) | Cite: | De novo design of potent and selective mimics of IL-2 and IL-15. Nature, 565, 2019
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6DG6
| Structure of a de novo designed Interleukin-2/Interleukin-15 mimetic | Descriptor: | Neoleukin-2/15 | Authors: | Jude, K.M, Silva, D.-A, Yu, S, Baker, D, Garcia, K.C. | Deposit date: | 2018-05-16 | Release date: | 2019-01-16 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.999 Å) | Cite: | De novo design of potent and selective mimics of IL-2 and IL-15. Nature, 565, 2019
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4DEP
| Structure of the IL-1b signaling complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-1 beta, Interleukin-1 receptor accessory protein, ... | Authors: | Thomas, C, Garcia, K.C. | Deposit date: | 2012-01-21 | Release date: | 2012-03-21 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structure of the activating IL-1 receptor signaling complex. Nat.Struct.Mol.Biol., 19, 2012
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4F0A
| Crystal structure of XWnt8 in complex with the cysteine-rich domain of Frizzled 8 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Frizzled-8, PALMITOLEIC ACID, ... | Authors: | Janda, C.Y, Waghray, D, Levin, A.M, Thomas, C, Garcia, K.C. | Deposit date: | 2012-05-03 | Release date: | 2012-06-13 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | Structural basis of Wnt recognition by Frizzled. Science, 337, 2012
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2IFG
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3PA8
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7RKX
| Structure of US27-Gi-scFv16 in CL-state | Descriptor: | Antibody fragment scFv16, G-protein coupled receptor homolog US27, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Tsutsumi, N, Jude, K.M, Garcia, K.C. | Deposit date: | 2021-07-22 | Release date: | 2022-01-26 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins Sci Adv, 8, 2022
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7RAA
| Designed StabIL-2 seq15 | Descriptor: | Interleukin-2, MAGNESIUM ION | Authors: | Jude, K.M, Chu, A.E, Huang, P.-S, Garcia, K.C. | Deposit date: | 2021-06-30 | Release date: | 2022-03-16 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.69 Å) | Cite: | Interleukin-2 superkines by computational design. Proc.Natl.Acad.Sci.USA, 119, 2022
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7RKY
| Binding mode of US27-Gi-scFv16 in OCL-state | Descriptor: | Antibody fragment scFv16, G-protein coupled receptor homolog US27, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Tsutsumi, N, Jude, K.M, Garcia, K.C. | Deposit date: | 2021-07-22 | Release date: | 2022-01-26 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins Sci Adv, 8, 2022
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7RKN
| Structure of CX3CL1-US28-Gi-scFv16 in OC-state | Descriptor: | Antibody fragment scFv16, Fractalkine, G-protein coupled receptor homolog US28, ... | Authors: | Tsutsumi, N, Qu, Q, Jude, K.M, Skiniotis, G, Garcia, K.C. | Deposit date: | 2021-07-22 | Release date: | 2022-01-26 | Last modified: | 2024-09-25 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins Sci Adv, 8, 2022
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7RKF
| Structure of CX3CL1-US28-G11iN18-scFv16 in TL-state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody fragment scFv16, Fractalkine, ... | Authors: | Tsutsumi, N, Maeda, S, Qu, Q, Skiniotis, G, Kobilka, B.K, Garcia, K.C. | Deposit date: | 2021-07-22 | Release date: | 2022-01-26 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins Sci Adv, 8, 2022
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7RKM
| Structure of CX3CL1-US28-Gi-scFv16 in C-state | Descriptor: | Antibody fragment scFv16, CHOLESTEROL, Fractalkine, ... | Authors: | Tsutsumi, N, Qu, Q, Jude, K.M, Skiniotis, G, Garcia, K.C. | Deposit date: | 2021-07-22 | Release date: | 2022-01-26 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins Sci Adv, 8, 2022
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2H3N
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