2IFG

Structure of the extracellular segment of human TRKA in complex with nerve growth factor

Summary for 2IFG

DescriptorHigh affinity nerve growth factor receptor, Beta-nerve growth factor, N-ACETYL-D-GLUCOSAMINE, ... (6 entities in total)
Functional Keywordstrk, trka, ngf, nerve growth factor, receptor-ligand complex, transferase
Biological sourceHomo sapiens (human)
Cellular locationCell membrane; Single-pass type I membrane protein (By similarity) P04629
Secreted P01138
Total number of polymer chains4
Total molecular weight109938.97
Authors
He, X.,Garcia, K.C. (deposition date: 2006-09-20, release date: 2007-02-13, Last modification date: 2011-07-13)
Primary citation
Wehrman, T.,He, X.,Raab, B.,Dukipatti, A.,Blau, H.,Garcia, K.C.
Structural and mechanistic insights into nerve growth factor interactions with the TrkA and p75 receptors.
Neuron, 53:25-38, 2007
PubMed: 17196528 (PDB entries with the same primary citation)
DOI: 10.1016/j.neuron.2006.09.034
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.4 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.330408.7%7.1%10.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2ifg
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Molmil generated image of 2ifg
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Molmil generated image of 2ifg
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