2IFG

Structure of the extracellular segment of human TRKA in complex with nerve growth factor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004714	molecular_function	transmembrane receptor protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0005886	cellular_component	plasma membrane
A	0006468	biological_process	protein phosphorylation
A	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway
B	0004714	molecular_function	transmembrane receptor protein tyrosine kinase activity
B	0005524	molecular_function	ATP binding
B	0005886	cellular_component	plasma membrane
B	0006468	biological_process	protein phosphorylation
B	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway
E	0005102	molecular_function	signaling receptor binding
F	0005102	molecular_function	signaling receptor binding

Functional Information from PROSITE/UniProt

site_id	PS00248
Number of Residues	14
Details	NGF_1 Nerve growth factor family signature. GCRGIDskhWnSyC

Chain	Residue	Details
E	GLY67-CYS80

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: in other chain => ECO:0000250|UniProtKB:P01139

Chain	Residue	Details
E	TYR52
F	TYR52
A	ASN253
A	ASN318
A	ASN323
A	ASN338
B	ASN67
B	ASN202
B	ASN253
B	ASN318
B	ASN323
B	ASN338

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P01139

Chain	Residue	Details
E	LYS88
F	LYS88
B	ASN95
B	ASN121

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site_id	SWS_FT_FI3
Number of Residues	8
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17196528, ECO:0007744|PDB:2IFG

Chain	Residue	Details
A	ASN188
A	ASN262
A	ASN281
A	ASN358
B	ASN188
B	ASN262
B	ASN281
B	ASN358

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