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7T7B
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BU of 7t7b by Molmil
Crystal structure of SARS-CoV-2 spike protein receptor-binding domain in complex with a cross-neutralizing antibody ADI-62113 Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ADI-62113 Fab heavy chain, ADI-62113 Fab light chain, ...
Authors:Liu, H, Wilson, I.A.
Deposit date:2021-12-14
Release date:2022-08-03
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Human antibodies to SARS-CoV-2 with a recurring YYDRxG motif retain binding and neutralization to variants of concern including Omicron.
Commun Biol, 5, 2022
7TP3
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BU of 7tp3 by Molmil
Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody K288.2
Descriptor: CACODYLATE ION, K288.2 heavy chain, K288.2 light chain, ...
Authors:Yuan, M, Zhu, X, Wilson, I.A.
Deposit date:2022-01-24
Release date:2022-02-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Broadly neutralizing antibodies to SARS-related viruses can be readily induced in rhesus macaques.
Sci Transl Med, 14, 2022
7TP4
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BU of 7tp4 by Molmil
Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody K398.22
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, K398.22 heavy chain, ...
Authors:Yuan, M, Zhu, X, Wilson, I.A.
Deposit date:2022-01-24
Release date:2022-02-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Broadly neutralizing antibodies to SARS-related viruses can be readily induced in rhesus macaques.
Sci Transl Med, 14, 2022
7TI6
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BU of 7ti6 by Molmil
Crystal structure of the wild-type least mutated common ancestor (LMCA) of the HIV-targeting PCT64 antibody lineage
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, PCT64_LMCA Fab heavy chain, PCT64_LMCA light chain (wild type)
Authors:Omorodion, O, Wilson, I.A.
Deposit date:2022-01-12
Release date:2022-10-05
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Human immunoglobulin repertoire analysis guides design of vaccine priming immunogens targeting HIV V2-apex broadly neutralizing antibody precursors.
Immunity, 55, 2022
7U5G
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BU of 7u5g by Molmil
ACS122 Fab
Descriptor: ACS122 Fab Heavy chain, ACS122 Fab Light chain
Authors:Farokhi, E, Stanfield, R.L, Wilson, I.A.
Deposit date:2022-03-02
Release date:2022-11-02
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Complementary antibody lineages achieve neutralization breadth in an HIV-1 infected elite neutralizer.
Plos Pathog., 18, 2022
7U8L
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BU of 7u8l by Molmil
Crystal structure of chimeric hemagglutinin cH15/3 in complex with broad protective antibody 31.a.83
Descriptor: Antibody Fab light chain, Hemagglutinin HA1 subunit, Hemagglutinin HA2 subunit, ...
Authors:Zhu, X, Wilson, I.A.
Deposit date:2022-03-08
Release date:2022-06-08
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (4.56 Å)
Cite:Influenza chimeric hemagglutinin structures in complex with broadly protective antibodies to the stem and trimer interface.
Proc.Natl.Acad.Sci.USA, 119, 2022
7U8M
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BU of 7u8m by Molmil
Crystal structure of chimeric hemagglutinin cH15/3 in complex with broad protective antibodies 31.a.83 and FluA-20
Descriptor: Antibody 31.a.83 Fab light chain, antibody 31.a.83 Fab heavy chain, antibody FluA-20 Fab heavy chain, ...
Authors:Zhu, X, Wilson, I.A.
Deposit date:2022-03-08
Release date:2022-06-08
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (5.39 Å)
Cite:Influenza chimeric hemagglutinin structures in complex with broadly protective antibodies to the stem and trimer interface.
Proc.Natl.Acad.Sci.USA, 119, 2022
7U8J
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BU of 7u8j by Molmil
Crystal structure of chimeric hemagglutinin cH4/3 in complex with broad protective antibody 31.a.83
Descriptor: Antibody Fab light chain, Hemagglutinin HA1 subunit, Hemagglutinin HA2 subunit, ...
Authors:Zhu, X, Wilson, I.A.
Deposit date:2022-03-08
Release date:2022-06-08
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (4.9 Å)
Cite:Influenza chimeric hemagglutinin structures in complex with broadly protective antibodies to the stem and trimer interface.
Proc.Natl.Acad.Sci.USA, 119, 2022
7U0K
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BU of 7u0k by Molmil
IOMA class antibody Fab ACS124
Descriptor: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, IOMA Class antibody ACS124 Heavy chain, IOMA Class antibody ACS124 Light chain
Authors:Farokhi, E, Stanfield, R.L, Wilson, I.A.
Deposit date:2022-02-18
Release date:2022-08-24
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Identification of IOMA-class neutralizing antibodies targeting the CD4-binding site on the HIV-1 envelope glycoprotein.
Nat Commun, 13, 2022
7U04
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BU of 7u04 by Molmil
IOMA class antibody ACS101
Descriptor: GLYCEROL, IOMA class antibody ACS101 heavy chain, IOMA class antibody ACS101 light chain
Authors:Farokhi, E, Stanfield, R.L, Wilson, I.A.
Deposit date:2022-02-17
Release date:2022-08-24
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Identification of IOMA-class neutralizing antibodies targeting the CD4-binding site on the HIV-1 envelope glycoprotein.
Nat Commun, 13, 2022
5HZQ
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BU of 5hzq by Molmil
Crystal structure of cellular retinoic acid binding protein 2 (CRABP2)-aryl fluorosulfate covalent conjugate
Descriptor: 4'-[(3,6,9,12-tetraoxapentadec-14-yn-1-yl)oxy][1,1'-biphenyl]-4-yl sulfurofluoridate, Cellular retinoic acid-binding protein 2, GLYCEROL
Authors:Chen, W, Mortenson, D.E, Wilson, I.A, Kelly, J.W.
Deposit date:2016-02-02
Release date:2016-06-01
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue.
J.Am.Chem.Soc., 138, 2016
5FEH
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BU of 5feh by Molmil
Crystal structure of PCT64_35B, a broadly neutralizing anti-HIV antibody
Descriptor: 1,2-ETHANEDIOL, PCT64_26 Fab heavy chain, PCT64_26 Fab light chain, ...
Authors:Murrell, S, Wilson, I.A.
Deposit date:2015-12-17
Release date:2017-08-16
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage.
Immunity, 47, 2017
5IF0
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BU of 5if0 by Molmil
Crystal structure of VRC01c-HuGL2 Fab from an HIV-1 naive donor in complex with with a germline-targeting gp120 engineered outer domain eOD-GT8 at 2.44 A
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Germline-targeting HIV-1 gp120 engineered outer domain eOD-GT8, PHOSPHATE ION, ...
Authors:Sarkar, A, Wilson, I.A.
Deposit date:2016-02-25
Release date:2016-04-06
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen.
Science, 351, 2016
5ILT
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BU of 5ilt by Molmil
Crystal structure of bovine Fab A01
Descriptor: bovine Fab A01 heavy chain, bovine Fab A01 light chain
Authors:Stanfield, R.L, Wilson, I.A.
Deposit date:2016-03-04
Release date:2016-08-24
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Conservation and diversity in the ultralong third heavy-chain complementarity-determining region of bovine antibodies.
Sci Immunol, 1, 2016
5IJV
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BU of 5ijv by Molmil
Crystal structure of bovine Fab E03
Descriptor: bovine Fab E03 heavy chain, bovine Fab E03 light chain
Authors:Stanfield, R.L, Wilson, I.A.
Deposit date:2016-03-02
Release date:2016-10-05
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Conservation and diversity in the ultralong third heavy-chain complementarity-determining region of bovine antibodies.
Sci Immunol, 1, 2016
8FO3
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BU of 8fo3 by Molmil
Structure of full-length amyloidogenic immunoglobulin light chain H9 in complex with (E)-3-nitro-4-(2-(2-phenylpropylidene)hydrazineyl)benzenesulfonamide
Descriptor: 3-nitro-4-{2-[(2S)-2-phenylpropyl]hydrazinyl}benzene-1-sulfonamide, H9 immunoglobulin light chain, PHOSPHATE ION
Authors:Yan, N.L, Wilson, I.A, Kelly, J.W.
Deposit date:2022-12-29
Release date:2023-05-24
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structures of Diaryl Hydrazone and Sulfone Stabilizers in Complex with an Amyloidogenic Light Chain Reveal an Alternate Ligand-Binding Cavity
Isr.J.Chem., 2023
8FO4
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BU of 8fo4 by Molmil
Structure of full-length amyloidogenic immunoglobulin light chain H9 in complex with 6-methyl-2-(2-((1E,2E)-3-(2-nitrophenyl)allylidene)hydrazineyl)pyrimidin-4-ol
Descriptor: 6-methyl-2-{2-[(1E)-3-(2-nitrophenyl)prop-1-en-1-yl]hydrazinyl}pyrimidin-4(5H)-one, H9 immunoglobulin light chain, PHOSPHATE ION
Authors:Yan, N.L, Wilson, I.A, Kelly, J.W.
Deposit date:2022-12-29
Release date:2023-05-24
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structures of Diaryl Hydrazone and Sulfone Stabilizers in Complex with an Amyloidogenic Light Chain Reveal an Alternate Ligand-Binding Cavity
Isr.J.Chem., 2023
8FO5
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BU of 8fo5 by Molmil
Structure of full-length amyloidogenic immunoglobulin light chain H9 in complex with 1-(1-(phenylsulfonyl)-1H-pyrrol-3-yl)ethan-1-one
Descriptor: 1-[1-(benzenesulfonyl)-1H-pyrrol-3-yl]ethan-1-one, H9 immunoglobulin light chain, PHOSPHATE ION
Authors:Yan, N.L, Wilson, I.A, Kelly, J.W.
Deposit date:2022-12-29
Release date:2023-05-24
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Crystal Structures of Diaryl Hydrazone and Sulfone Stabilizers in Complex with an Amyloidogenic Light Chain Reveal an Alternate Ligand-Binding Cavity
Isr.J.Chem., 2023
8GF2
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BU of 8gf2 by Molmil
Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies eCR3022.20 and CC12.3
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CC12.3 Fab heavy chain, ...
Authors:Yuan, M, Zhu, X, Wilson, I.A.
Deposit date:2023-03-07
Release date:2023-08-23
Method:X-RAY DIFFRACTION (2.851 Å)
Cite:Broadening a SARS-CoV-1-neutralizing antibody for potent SARS-CoV-2 neutralization through directed evolution.
Sci.Signal., 16, 2023
5JS9
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BU of 5js9 by Molmil
Uncleaved prefusion optimized gp140 trimer with an engineered 8-residue HR1 turn bound to broadly neutralizing antibodies 8ANC195 and PGT128
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Kong, L, Wilson, I.A.
Deposit date:2016-05-07
Release date:2016-07-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (6.918 Å)
Cite:Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability.
Nat Commun, 7, 2016
5JSA
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BU of 5jsa by Molmil
Uncleaved prefusion optimized gp140 trimer with an engineered 10-residue HR1 turn bound to broadly neutralizing antibodies 8ANC195 and PGT128
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Kong, L, Wilson, I.A.
Deposit date:2016-05-07
Release date:2016-07-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (6.308 Å)
Cite:Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability.
Nat Commun, 7, 2016
5JOP
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BU of 5jop by Molmil
Crystal structure of anti-glycan antibody Fab14.22 in complex with Streptococcus pneumoniae serotype 14 tetrasaccharide at 1.75 A
Descriptor: Fab 14.22 light chain, Fab14.22 heavy chain, GLYCEROL, ...
Authors:Sarkar, A, Irimia, A, Teyton, L, Wilson, I.A.
Deposit date:2016-05-02
Release date:2017-03-22
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:T cells control the generation of nanomolar-affinity anti-glycan antibodies.
J. Clin. Invest., 127, 2017
5KUX
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BU of 5kux by Molmil
Designed influenza hemagglutinin binding protein HSB.2
Descriptor: Designed influenza inhibitor protein HSB.2
Authors:Lee, P.S, Bernard, S.M, Wilson, I.A.
Deposit date:2016-07-13
Release date:2017-06-14
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Computational design of trimeric influenza-neutralizing proteins targeting the hemagglutinin receptor binding site.
Nat. Biotechnol., 35, 2017
5KUY
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BU of 5kuy by Molmil
Influenza hemagglutinin H3 A/Hong Kong/1/1968 in complex with designed inhibitor protein HSB.2A
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Designed influenza inhibitor HSB.2A, ...
Authors:Bernard, S.M, Wilson, I.A.
Deposit date:2016-07-13
Release date:2017-06-14
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.598 Å)
Cite:Computational design of trimeric influenza-neutralizing proteins targeting the hemagglutinin receptor binding site.
Nat. Biotechnol., 35, 2017
5JOR
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BU of 5jor by Molmil
Crystal structure of unbound anti-glycan antibody Fab14.22 at 2.2 A
Descriptor: Fab 14.22 light chain, Fab14.22 heavy chain, GLYCEROL, ...
Authors:Sarkar, A, Irimia, A, Teyton, L, Wilson, I.A.
Deposit date:2016-05-02
Release date:2017-03-22
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.206 Å)
Cite:T cells control the generation of nanomolar-affinity anti-glycan antibodies.
J. Clin. Invest., 127, 2017

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