8FO3

Structure of full-length amyloidogenic immunoglobulin light chain H9 in complex with (E)-3-nitro-4-(2-(2-phenylpropylidene)hydrazineyl)benzenesulfonamide

Summary for 8FO3

Entry DOI	10.2210/pdb8fo3/pdb
Descriptor	H9 immunoglobulin light chain, 3-nitro-4-{2-[(2S)-2-phenylpropyl]hydrazinyl}benzene-1-sulfonamide, PHOSPHATE ION, ... (4 entities in total)
Functional Keywords	light chain, amyloidosis, stabilizer, immune system
Biological source	Homo sapiens (human)
Total number of polymer chains	12
Total formula weight	273268.08
Authors	Yan, N.L.,Wilson, I.A.,Kelly, J.W. (deposition date: 2022-12-29, release date: 2023-05-24, Last modification date: 2024-10-23)
Primary citation	Yan, N.L.,Wilson, I.A.,Kelly, J.W. Crystal Structures of Diaryl Hydrazone and Sulfone Stabilizers in Complex with an Amyloidogenic Light Chain Reveal an Alternate Ligand-Binding Cavity Isr.J.Chem., 2023 Cited by DOI: 10.1002/ijch.202300002 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation