8FO3
Structure of full-length amyloidogenic immunoglobulin light chain H9 in complex with (E)-3-nitro-4-(2-(2-phenylpropylidene)hydrazineyl)benzenesulfonamide
Summary for 8FO3
Entry DOI | 10.2210/pdb8fo3/pdb |
Descriptor | H9 immunoglobulin light chain, 3-nitro-4-{2-[(2S)-2-phenylpropyl]hydrazinyl}benzene-1-sulfonamide, PHOSPHATE ION, ... (4 entities in total) |
Functional Keywords | light chain, amyloidosis, stabilizer, immune system |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 12 |
Total formula weight | 273268.08 |
Authors | Yan, N.L.,Wilson, I.A.,Kelly, J.W. (deposition date: 2022-12-29, release date: 2023-05-24, Last modification date: 2023-10-25) |
Primary citation | Yan, N.L.,Wilson, I.A.,Kelly, J.W. Crystal Structures of Diaryl Hydrazone and Sulfone Stabilizers in Complex with an Amyloidogenic Light Chain Reveal an Alternate Ligand-Binding Cavity Isr.J.Chem., 2023 Cited by DOI: 10.1002/ijch.202300002PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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