7TI6

Crystal structure of the wild-type least mutated common ancestor (LMCA) of the HIV-targeting PCT64 antibody lineage

Summary for 7TI6

• Entry DOI: 10.2210/pdb7ti6/pdb
• Descriptor: PCT64_LMCA Fab heavy chain, PCT64_LMCA light chain (wild type), 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (4 entities in total)
• Functional Keywords: antibody, broadly neutralizing, hiv-1, v2 apex, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 2
• Total formula weight: 49346.84

Authors

Omorodion, O.,Wilson, I.A. (deposition date: 2022-01-12, release date: 2022-10-05, Last modification date: 2023-10-18)

• Primary citation: Willis, J.R.,Berndsen, Z.T.,Ma, K.M.,Steichen, J.M.,Schiffner, T.,Landais, E.,Liguori, A.,Kalyuzhniy, O.,Allen, J.D.,Baboo, S.,Omorodion, O.,Diedrich, J.K.,Hu, X.,Georgeson, E.,Phelps, N.,Eskandarzadeh, S.,Groschel, B.,Kubitz, M.,Adachi, Y.,Mullin, T.M.,Alavi, N.B.,Falcone, S.,Himansu, S.,Carfi, A.,Wilson, I.A.,Yates 3rd, J.R.,Paulson, J.C.,Crispin, M.,Ward, A.B.,Schief, W.R.; Human immunoglobulin repertoire analysis guides design of vaccine priming immunogens targeting HIV V2-apex broadly neutralizing antibody precursors.; Immunity, 55:2149-2167.e9, 2022; PubMed: 36179689; DOI: 10.1016/j.immuni.2022.09.001

Experimental method

X-RAY DIFFRACTION (2.64 Å)