7TI6
Crystal structure of the wild-type least mutated common ancestor (LMCA) of the HIV-targeting PCT64 antibody lineage
Summary for 7TI6
Entry DOI | 10.2210/pdb7ti6/pdb |
Descriptor | PCT64_LMCA Fab heavy chain, PCT64_LMCA light chain (wild type), 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (4 entities in total) |
Functional Keywords | antibody, broadly neutralizing, hiv-1, v2 apex, immune system |
Biological source | Homo sapiens More |
Total number of polymer chains | 2 |
Total formula weight | 49346.84 |
Authors | Omorodion, O.,Wilson, I.A. (deposition date: 2022-01-12, release date: 2022-10-05, Last modification date: 2023-10-18) |
Primary citation | Willis, J.R.,Berndsen, Z.T.,Ma, K.M.,Steichen, J.M.,Schiffner, T.,Landais, E.,Liguori, A.,Kalyuzhniy, O.,Allen, J.D.,Baboo, S.,Omorodion, O.,Diedrich, J.K.,Hu, X.,Georgeson, E.,Phelps, N.,Eskandarzadeh, S.,Groschel, B.,Kubitz, M.,Adachi, Y.,Mullin, T.M.,Alavi, N.B.,Falcone, S.,Himansu, S.,Carfi, A.,Wilson, I.A.,Yates 3rd, J.R.,Paulson, J.C.,Crispin, M.,Ward, A.B.,Schief, W.R. Human immunoglobulin repertoire analysis guides design of vaccine priming immunogens targeting HIV V2-apex broadly neutralizing antibody precursors. Immunity, 55:2149-2167.e9, 2022 Cited by PubMed: 36179689DOI: 10.1016/j.immuni.2022.09.001 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.64 Å) |
Structure validation
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