6GCX
| Focal Adhesion Kinase catalytic domain in complex with irreversible inhibitor | Descriptor: | 2-[[2-[[4-[[[3,4-bis(oxidanylidene)-2-[2-(propanoylamino)ethylamino]cyclobuten-1-yl]amino]methyl]phenyl]amino]-5-chloranyl-pyrimidin-4-yl]amino]-~{N}-methyl-benzamide, Focal adhesion kinase 1, SULFATE ION | Authors: | Yen-Pon, E, Li, B, Acebron-Garcia de Eulate, M, Tomkiewicz-Raulet, C, Dawson, J, Lietha, D, Frame, M.C, Coumoul, X, Garbay, C, Etheve-Quelquejeu, M, Chen, H. | Deposit date: | 2018-04-19 | Release date: | 2019-05-01 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.553 Å) | Cite: | Structure-Based Design, Synthesis, and Characterization of the First Irreversible Inhibitor of Focal Adhesion Kinase. Acs Chem.Biol., 13, 2018
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6GCR
| Focal Adhesion Kinase catalytic domain in complex with irreversible inhibitor | Descriptor: | 2-[[2-[[4-[[[3,4-bis(oxidanylidene)-2-[2-(propanoylamino)ethylamino]cyclobuten-1-yl]amino]methyl]phenyl]amino]-5-chloranyl-pyrimidin-4-yl]amino]-~{N}-methyl-benzamide, Focal adhesion kinase 1 | Authors: | Yen-Pon, E, Li, B, Acebron-Garcia de Eulate, M, Tomkiewicz-Raulet, C, Dawson, J, Lietha, D, Frame, M.C, Coumoul, X, Garbay, C, Etheve-Quelquejeu, M, Chen, H. | Deposit date: | 2018-04-19 | Release date: | 2019-05-01 | Last modified: | 2019-10-02 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure-Based Design, Synthesis, and Characterization of the First Irreversible Inhibitor of Focal Adhesion Kinase. Acs Chem.Biol., 13, 2018
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6IPQ
| Non-native ferritin 8-mer mutant-C90A/C102A/C130A | Descriptor: | Ferritin heavy chain, MAGNESIUM ION | Authors: | Zang, J, Chen, H, Wang, Y, Zhao, G. | Deposit date: | 2018-11-03 | Release date: | 2019-03-13 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (3.103 Å) | Cite: | Disulfide-mediated conversion of 8-mer bowl-like protein architecture into three different nanocages. Nat Commun, 10, 2019
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6IPO
| Ferritin mutant C90A/C102A/C130A/D144C | Descriptor: | Ferritin heavy chain, MAGNESIUM ION | Authors: | Zang, J, Chen, H, Zhang, X, Zhao, G. | Deposit date: | 2018-11-03 | Release date: | 2019-03-13 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.998 Å) | Cite: | Disulfide-mediated conversion of 8-mer bowl-like protein architecture into three different nanocages. Nat Commun, 10, 2019
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6IPC
| Non-native human ferritin 8-mer | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Ferritin heavy chain | Authors: | Zang, J.C, Chen, H, Zhao, G. | Deposit date: | 2018-11-03 | Release date: | 2019-03-13 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (4.443 Å) | Cite: | Disulfide-mediated conversion of 8-mer bowl-like protein architecture into three different nanocages. Nat Commun, 10, 2019
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1S9I
| X-ray structure of the human mitogen-activated protein kinase kinase 2 (MEK2)in a complex with ligand and MgATP | Descriptor: | 5-{3,4-DIFLUORO-2-[(2-FLUORO-4-IODOPHENYL)AMINO]PHENYL}-N-(2-MORPHOLIN-4-YLETHYL)-1,3,4-OXADIAZOL-2-AMINE, ADENOSINE-5'-TRIPHOSPHATE, Dual specificity mitogen-activated protein kinase kinase 2, ... | Authors: | Ohren, J.F, Chen, H, Pavlovsky, A, Whitehead, C, Yan, C, McConnell, P, Delaney, A, Dudley, D.T, Sebolt-Leopold, J, Hasemann, C.A. | Deposit date: | 2004-02-04 | Release date: | 2004-11-23 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition. Nat.Struct.Mol.Biol., 11, 2004
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1S9J
| X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP | Descriptor: | 5-BROMO-N-(2,3-DIHYDROXYPROPOXY)-3,4-DIFLUORO-2-[(2-FLUORO-4-IODOPHENYL)AMINO]BENZAMIDE, ADENOSINE-5'-TRIPHOSPHATE, Dual specificity mitogen-activated protein kinase kinase 1, ... | Authors: | Ohren, J.F, Chen, H, Pavlovsky, A, Whitehead, C, Yan, C, McConnell, P, Delaney, A, Dudley, D.T, Sebolt-Leopold, J, Hasemann, C.A. | Deposit date: | 2004-02-04 | Release date: | 2004-11-23 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition. Nat.Struct.Mol.Biol., 11, 2004
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6UZ8
| Cryo-EM structure of human TRPC6 in complex with agonist AM-0883 | Descriptor: | (5-chloro-1'H-spiro[indole-3,4'-piperidin]-1'-yl)[(2R)-2,3-dihydro-1,4-benzodioxin-2-yl]methanone, 2-[[(2~{S})-2-decanoyloxy-3-dodecanoyloxy-propoxy]-oxidanyl-phosphoryl]oxyethyl-trimethyl-azanium, CHOLESTEROL HEMISUCCINATE, ... | Authors: | Bai, Y, Yu, X, Huang, X, Chen, H. | Deposit date: | 2019-11-14 | Release date: | 2020-03-18 | Method: | ELECTRON MICROSCOPY (2.84 Å) | Cite: | Structural basis for pharmacological modulation of the TRPC6 channel. Elife, 9, 2020
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6UZA
| Cryo-EM structure of human TRPC6 in complex with antagonist AM-1473 | Descriptor: | 2-[[(2~{S})-2-decanoyloxypropoxy]-oxidanyl-phosphoryl]oxyethyl-trimethyl-azanium, 4-({(1R,2R)-2-[(3R)-3-aminopiperidin-1-yl]-2,3-dihydro-1H-inden-1-yl}oxy)benzonitrile, CHOLESTEROL HEMISUCCINATE, ... | Authors: | Bai, Y, Yu, X, Huang, X, Chen, H. | Deposit date: | 2019-11-14 | Release date: | 2020-03-18 | Method: | ELECTRON MICROSCOPY (3.08 Å) | Cite: | Structural basis for pharmacological modulation of the TRPC6 channel. Elife, 9, 2020
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8J5Y
| Structural and mechanistic insight into ribosomal ITS2 RNA processing by nuclease-kinase machinery | Descriptor: | LAS1 isoform 1, Polynucleotide 5'-hydroxyl-kinase GRC3 | Authors: | Chen, J, Chen, H, Li, S, Lin, X, Hu, R, Zhang, K, Liu, L. | Deposit date: | 2023-04-24 | Release date: | 2024-01-17 | Method: | ELECTRON MICROSCOPY (3.07 Å) | Cite: | Structural and mechanistic insights into ribosomal ITS2 RNA processing by nuclease-kinase machinery. Elife, 12, 2024
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8J60
| Structural and mechanistic insight into ribosomal ITS2 RNA processing by nuclease-kinase machinery | Descriptor: | LAS1 protein, Polynucleotide 5'-hydroxyl-kinase GRC3 | Authors: | Chen, J, Chen, H, Li, S, Lin, X, Hu, R, Zhang, K, Liu, L. | Deposit date: | 2023-04-24 | Release date: | 2024-01-17 | Method: | ELECTRON MICROSCOPY (3.39 Å) | Cite: | Structural and mechanistic insights into ribosomal ITS2 RNA processing by nuclease-kinase machinery. Elife, 12, 2024
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2HPV
| Crystal structure of FMN-Dependent azoreductase from Enterococcus faecalis | Descriptor: | FLAVIN MONONUCLEOTIDE, FMN-dependent NADH-azoreductase | Authors: | Liu, Z.J, Chen, L, Chen, H, Rose, J, Wang, B.C, Southeast Collaboratory for Structural Genomics (SECSG) | Deposit date: | 2006-07-17 | Release date: | 2006-09-12 | Last modified: | 2017-09-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal Structure of Fmn-Dependent Azoreductase from Enterococcus faecalis at 2.00 A resolution To be Published
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8SKL
| PTP1B in complex with 182 | Descriptor: | 1,2-ETHANEDIOL, 5-[1-fluoro-3-hydroxy-7-(3-hydroxy-3-methylbutoxy)naphthalen-2-yl]-1lambda~6~,2,5-thiadiazolidine-1,1,3-trione, CHLORIDE ION, ... | Authors: | Babon, J.J, Chen, H, Tiganis, T. | Deposit date: | 2023-04-20 | Release date: | 2023-08-02 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity. Nat Commun, 14, 2023
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5CRL
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5VDI
| Crystal Structure of Human Glycine Receptor alpha-3 Mutant N38Q Bound to AM-3607, Glycine, and Ivermectin | Descriptor: | (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside, (3S,3aS,9bS)-2-[(2H-1,3-benzodioxol-5-yl)sulfonyl]-3,5-dimethyl-1,2,3,3a,5,9b-hexahydro-4H-pyrrolo[3,4-c][1,6]naphthyridin-4-one, GLYCINE, ... | Authors: | Shaffer, P.L, Huang, X, Chen, H. | Deposit date: | 2017-04-03 | Release date: | 2017-05-24 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Crystal Structures of Human GlyR alpha 3 Bound to Ivermectin. Structure, 25, 2017
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5VDH
| Crystal Structure of Human Glycine Receptor alpha-3 Bound to AM-3607, Glycine, and Ivermectin | Descriptor: | (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside, (3S,3aS,9bS)-2-[(2H-1,3-benzodioxol-5-yl)sulfonyl]-3,5-dimethyl-1,2,3,3a,5,9b-hexahydro-4H-pyrrolo[3,4-c][1,6]naphthyridin-4-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Shaffer, P.L, Huang, X, Chen, H. | Deposit date: | 2017-04-03 | Release date: | 2017-05-24 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Crystal Structures of Human GlyR alpha 3 Bound to Ivermectin. Structure, 25, 2017
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1VOL
| TFIIB (HUMAN CORE DOMAIN)/TBP (A.THALIANA)/TATA ELEMENT TERNARY COMPLEX | Descriptor: | DNA (5'-D(*CP*AP*GP*CP*CP*CP*TP*TP*TP*TP*AP*TP*AP*GP*CP*C)-3'), DNA (5'-D(*GP*GP*CP*TP*AP*TP*AP*AP*AP*AP*GP*GP*GP*CP*TP*G)-3'), PROTEIN (TATA BINDING PROTEIN (TBP)), ... | Authors: | Nikolov, D.B, Chen, H, Halay, E.D, Usheva, A.U, Hisatake, K, Lee, D.K, Roeder, R.G, Burley, S.K. | Deposit date: | 1996-04-29 | Release date: | 1996-11-08 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of a TFIIB-TBP-TATA-element ternary complex. Nature, 377, 1995
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8EQB
| FAM46C/BCCIPalpha/Nanobody complex | Descriptor: | Isoform 2 of BRCA2 and CDKN1A-interacting protein, Synthetic nanobody 1, Terminal nucleotidyltransferase 5C | Authors: | Liu, S, Chen, H, Yin, Y, Bai, X, Zhang, X. | Deposit date: | 2022-10-07 | Release date: | 2023-03-15 | Last modified: | 2023-04-26 | Method: | ELECTRON MICROSCOPY (6.5 Å) | Cite: | Inhibition of FAM46/TENT5 activity by BCCIP alpha adopting a unique fold. Sci Adv, 9, 2023
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1JFI
| Crystal Structure of the NC2-TBP-DNA Ternary Complex | Descriptor: | 5'-D(*G*GP*AP*GP*CP*CP*CP*TP*TP*TP*TP*AP*TP*AP*GP*CP*CP*AP*A)-3', 5'-D(*TP*TP*GP*GP*CP*TP*AP*TP*AP*AP*AP*AP*GP*GP*GP*CP*TP*CP*C)-3', TATA-BOX-BINDING PROTEIN (TBP), ... | Authors: | Kamada, K, Shu, F, Chen, H, Malik, S, Stelzer, G, Roeder, R.G, Meisterernst, M, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2001-06-20 | Release date: | 2001-07-11 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.62 Å) | Cite: | Crystal structure of negative cofactor 2 recognizing the TBP-DNA transcription complex. Cell(Cambridge,Mass.), 106, 2001
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5XXE
| Crystal structure of Poz1 and Tpz1 | Descriptor: | Protection of telomeres protein poz1, Protection of telomeres protein tpz1, SULFATE ION, ... | Authors: | Xue, J, Chen, H, Wu, J, Lei, M. | Deposit date: | 2017-07-03 | Release date: | 2017-12-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of the fission yeast S. pombe telomeric Tpz1-Poz1-Rap1 complex. Cell Res., 27, 2017
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1KBH
| Mutual Synergistic Folding in the Interaction Between Nuclear Receptor Coactivators CBP and ACTR | Descriptor: | CREB-BINDING PROTEIN, nuclear receptor coactivator | Authors: | Demarest, S.J, Martinez-Yamout, M, Chung, J, Chen, H, Xu, W, Dyson, H.J, Evans, R.M, Wright, P.E. | Deposit date: | 2001-11-06 | Release date: | 2002-02-06 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators. Nature, 415, 2002
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5XXF
| Crystal structure of Poz1, Tpz1 and Rap1 | Descriptor: | Protection of telomeres protein poz1, Protection of telomeres protein tpz1, Rap1, ... | Authors: | Xue, J, Chen, H, Wu, J, Lei, M. | Deposit date: | 2017-07-03 | Release date: | 2017-12-20 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structure of the fission yeast S. pombe telomeric Tpz1-Poz1-Rap1 complex. Cell Res., 27, 2017
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2KI0
| NMR Structure of a de novo designed beta alpha beta | Descriptor: | DS119 | Authors: | Liang, H, Chen, H, Fan, K, Wei, P, Guo, X, Jin, C, Zeng, C, Tang, C, Lai, L. | Deposit date: | 2009-04-18 | Release date: | 2009-10-20 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | De novo design of a beta alpha beta motif. Angew.Chem.Int.Ed.Engl., 48, 2009
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5CUQ
| Identification and characterization of novel broad spectrum inhibitors of the flavivirus methyltransferase | Descriptor: | N,N'-BIS(4-AMINO-2-METHYLQUINOLIN-6-YL)UREA, Nonstructural protein NS5 | Authors: | Brecher, B, Chen, H, Li, Z, Banavali, N.K, Jones, S.A, Zhang, J, Kramer, L.D, Li, H.M. | Deposit date: | 2015-07-24 | Release date: | 2016-02-03 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.696 Å) | Cite: | Identification and Characterization of Novel Broad-Spectrum Inhibitors of the Flavivirus Methyltransferase. Acs Infect Dis., 1, 2015
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1MV5
| Crystal structure of LmrA ATP-binding domain | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Yuan, Y, Chen, H, Patel, D. | Deposit date: | 2002-09-24 | Release date: | 2003-12-02 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Crystal structure of LmrA ATP-binding domain reveals the two-site alternating mechanism at molecular level To be Published
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