6UZ8
Cryo-EM structure of human TRPC6 in complex with agonist AM-0883
Summary for 6UZ8
Entry DOI | 10.2210/pdb6uz8/pdb |
EMDB information | 20953 |
Descriptor | Short transient receptor potential channel 6, 2-[[(2~{S})-2-decanoyloxy-3-dodecanoyloxy-propoxy]-oxidanyl-phosphoryl]oxyethyl-trimethyl-azanium, CHOLESTEROL HEMISUCCINATE, ... (4 entities in total) |
Functional Keywords | trp channel, agonist, transport protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 396575.42 |
Authors | |
Primary citation | Bai, Y.,Yu, X.,Chen, H.,Horne, D.,White, R.,Wu, X.,Lee, P.,Gu, Y.,Ghimire-Rijal, S.,Lin, D.C.,Huang, X. Structural basis for pharmacological modulation of the TRPC6 channel. Elife, 9:-, 2020 Cited by PubMed: 32149605DOI: 10.7554/eLife.53311 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.84 Å) |
Structure validation
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