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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6UZ8

Cryo-EM structure of human TRPC6 in complex with agonist AM-0883

Functional Information from GO Data
ChainGOidnamespacecontents
A0005216molecular_functionmonoatomic ion channel activity
A0005261molecular_functionmonoatomic cation channel activity
A0005262molecular_functioncalcium channel activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006812biological_processmonoatomic cation transport
A0006816biological_processcalcium ion transport
A0007338biological_processsingle fertilization
A0015279molecular_functionstore-operated calcium channel activity
A0016020cellular_componentmembrane
A0032414biological_processpositive regulation of ion transmembrane transporter activity
A0034220biological_processmonoatomic ion transmembrane transport
A0034703cellular_componentcation channel complex
A0036057cellular_componentslit diaphragm
A0042803molecular_functionprotein homodimerization activity
A0051480biological_processregulation of cytosolic calcium ion concentration
A0051928biological_processpositive regulation of calcium ion transport
A0055085biological_processtransmembrane transport
A0070588biological_processcalcium ion transmembrane transport
A0070679molecular_functioninositol 1,4,5 trisphosphate binding
B0005216molecular_functionmonoatomic ion channel activity
B0005261molecular_functionmonoatomic cation channel activity
B0005262molecular_functioncalcium channel activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006812biological_processmonoatomic cation transport
B0006816biological_processcalcium ion transport
B0007338biological_processsingle fertilization
B0015279molecular_functionstore-operated calcium channel activity
B0016020cellular_componentmembrane
B0032414biological_processpositive regulation of ion transmembrane transporter activity
B0034220biological_processmonoatomic ion transmembrane transport
B0034703cellular_componentcation channel complex
B0036057cellular_componentslit diaphragm
B0042803molecular_functionprotein homodimerization activity
B0051480biological_processregulation of cytosolic calcium ion concentration
B0051928biological_processpositive regulation of calcium ion transport
B0055085biological_processtransmembrane transport
B0070588biological_processcalcium ion transmembrane transport
B0070679molecular_functioninositol 1,4,5 trisphosphate binding
C0005216molecular_functionmonoatomic ion channel activity
C0005261molecular_functionmonoatomic cation channel activity
C0005262molecular_functioncalcium channel activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006812biological_processmonoatomic cation transport
C0006816biological_processcalcium ion transport
C0007338biological_processsingle fertilization
C0015279molecular_functionstore-operated calcium channel activity
C0016020cellular_componentmembrane
C0032414biological_processpositive regulation of ion transmembrane transporter activity
C0034220biological_processmonoatomic ion transmembrane transport
C0034703cellular_componentcation channel complex
C0036057cellular_componentslit diaphragm
C0042803molecular_functionprotein homodimerization activity
C0051480biological_processregulation of cytosolic calcium ion concentration
C0051928biological_processpositive regulation of calcium ion transport
C0055085biological_processtransmembrane transport
C0070588biological_processcalcium ion transmembrane transport
C0070679molecular_functioninositol 1,4,5 trisphosphate binding
D0005216molecular_functionmonoatomic ion channel activity
D0005261molecular_functionmonoatomic cation channel activity
D0005262molecular_functioncalcium channel activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006812biological_processmonoatomic cation transport
D0006816biological_processcalcium ion transport
D0007338biological_processsingle fertilization
D0015279molecular_functionstore-operated calcium channel activity
D0016020cellular_componentmembrane
D0032414biological_processpositive regulation of ion transmembrane transporter activity
D0034220biological_processmonoatomic ion transmembrane transport
D0034703cellular_componentcation channel complex
D0036057cellular_componentslit diaphragm
D0042803molecular_functionprotein homodimerization activity
D0051480biological_processregulation of cytosolic calcium ion concentration
D0051928biological_processpositive regulation of calcium ion transport
D0055085biological_processtransmembrane transport
D0070588biological_processcalcium ion transmembrane transport
D0070679molecular_functioninositol 1,4,5 trisphosphate binding
Functional Information from PDB Data
site_idAC1
Number of Residues7
Detailsbinding site for residue SBM A 1001
ChainResidue
AGLU524
ATRP526
AALA611
ATYR612
AGLN624
AGLY628
AVAL631
site_idAC2
Number of Residues9
Detailsbinding site for residue Y01 A 1002
ChainResidue
AMET403
ALYS406
APHE407
APHE440
ATHR451
AALA616
AASN617
ATRP391
ATYR392
site_idAC3
Number of Residues6
Detailsbinding site for residue R0D A 1003
ChainResidue
ATYR705
AGLY709
DGLU672
DPHE675
DPHE679
DTRP680
site_idAC4
Number of Residues3
Detailsbinding site for residue Y01 A 1004
ChainResidue
ALYS698
APHE699
AASN702
site_idAC5
Number of Residues7
Detailsbinding site for residue SBM D 1001
ChainResidue
DGLU524
DTRP526
DALA611
DTYR612
DGLN624
DGLY628
DVAL631
site_idAC6
Number of Residues9
Detailsbinding site for residue Y01 D 1002
ChainResidue
DTRP391
DTYR392
DMET403
DLYS406
DPHE407
DPHE440
DTHR451
DALA616
DASN617
site_idAC7
Number of Residues6
Detailsbinding site for residue R0D D 1003
ChainResidue
CGLU672
CPHE675
CPHE679
CTRP680
DTYR705
DGLY709
site_idAC8
Number of Residues3
Detailsbinding site for residue Y01 D 1004
ChainResidue
DLYS698
DPHE699
DASN702
site_idAC9
Number of Residues6
Detailsbinding site for residue R0D B 1001
ChainResidue
AGLU672
APHE675
APHE679
ATRP680
BTYR705
BGLY709
site_idAD1
Number of Residues3
Detailsbinding site for residue Y01 B 1002
ChainResidue
BLYS698
BPHE699
BASN702
site_idAD2
Number of Residues7
Detailsbinding site for residue SBM B 1003
ChainResidue
BGLU524
BTRP526
BALA611
BTYR612
BGLN624
BGLY628
BVAL631
site_idAD3
Number of Residues9
Detailsbinding site for residue Y01 B 1004
ChainResidue
BTRP391
BTYR392
BMET403
BLYS406
BPHE407
BPHE440
BTHR451
BALA616
BASN617
site_idAD4
Number of Residues6
Detailsbinding site for residue R0D C 1001
ChainResidue
BGLU672
BPHE675
BPHE679
BTRP680
CTYR705
CGLY709
site_idAD5
Number of Residues3
Detailsbinding site for residue Y01 C 1002
ChainResidue
CLYS698
CPHE699
CASN702
site_idAD6
Number of Residues7
Detailsbinding site for residue SBM C 1003
ChainResidue
CGLU524
CTRP526
CALA611
CTYR612
CGLN624
CGLY628
CVAL631
site_idAD7
Number of Residues9
Detailsbinding site for residue Y01 C 1004
ChainResidue
CASN617
CTRP391
CTYR392
CMET403
CLYS406
CPHE407
CPHE440
CTHR451
CALA616
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues480
DetailsTransmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues300
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues136
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues116
DetailsRepeat: {"description":"ANK 1"}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues116
DetailsRepeat: {"description":"ANK 2"}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues104
DetailsRepeat: {"description":"ANK 3"}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues116
DetailsRepeat: {"description":"ANK 4"}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12970363","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

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