6UZ8
Cryo-EM structure of human TRPC6 in complex with agonist AM-0883
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, D, B, C) | Short transient receptor potential channel 6 | polymer | 847 | 97192.8 | 4 | UniProt (Q9Y210) Pfam (PF12796) Pfam (PF08344) Pfam (PF00520) | Homo sapiens (Human) | TrpC6,Transient receptor protein 6,TRP-6 |
| 2 | E, I, O, S (A, D, B, C) | 2-[[(2~{S})-2-decanoyloxy-3-dodecanoyloxy-propoxy]-oxidanyl-phosphoryl]oxyethyl-trimethyl-azanium | non-polymer | 594.8 | 4 | Chemie (SBM) PubChem (132285117) PubChem (145997910) PubChem (5313034) | |||
| 3 | F, H, J, L, N... (A, D, B, C) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 8 | Chemie (Y01) PubChem (16219150) PubChem (22210610) PubChem (45489984) PubChem (60078761) PubChem (73440805) PubChem (99567469) PubChem (124301053) PubChem (124302591) PubChem (124303794) PubChem (124421343) PubChem (124427195) PubChem (124914595) PubChem (124914596) PubChem (131705526) PubChem (137332121) PubChem (137496357) PubChem (146157332) PubChem (154929912) PubChem (155199678) PubChem (156327905) PubChem (156426247) PubChem (156516588) PubChem (166979870) PubChem (167024614) PubChem (169132513) PubChem (170117245) PubChem (172400028) PubChem (57163942) PubChem (89891013) PubChem (99567468) PubChem (124427194) PubChem (124897021) PubChem (124897020) PubChem (10005657) PubChem (130340716) PubChem (11969853) PubChem (137392566) PubChem (137496323) PubChem (155804219) PubChem (169132514) PubChem (65082) PubChem (363416) PubChem (500055) PubChem (13301926) PubChem (13301927) | |||
| 4 | G, K, M, Q (A, D, B, C) | (5-chloro-1'H-spiro[indole-3,4'-piperidin]-1'-yl)[(2R)-2,3-dihydro-1,4-benzodioxin-2-yl]methanone | non-polymer | 382.8 | 4 | Chemie (R0D) PubChem (146018715) |
Sequence modifications
A, D, B, C: 85 - 931 (UniProt: Q9Y210)
| PDB | External Database | Details |
|---|---|---|
| Thr 867 | Val 867 | conflict |
| Thr 868 | Leu 868 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 388771.1 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 7804.3 | |
| All* | Total formula weight | 396575.4 |
