6UZ8
Cryo-EM structure of human TRPC6 in complex with agonist AM-0883
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, D, B, C) | Short transient receptor potential channel 6 | polymer | 847 | 97192.8 | 4 | UniProt (Q9Y210) Pfam (PF12796) Pfam (PF08344) Pfam (PF00520) Pfam (PF08016) | Homo sapiens (Human) | TrpC6,Transient receptor protein 6,TRP-6 |
| 2 | E, I, O, S (A, D, B, C) | 2-[[(2~{S})-2-decanoyloxy-3-dodecanoyloxy-propoxy]-oxidanyl-phosphoryl]oxyethyl-trimethyl-azanium | non-polymer | 594.8 | 4 | Chemie (SBM) | |||
| 3 | F, H, J, L, N... (A, D, B, C) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 8 | Chemie (Y01) | |||
| 4 | G, K, M, Q (A, D, B, C) | (5-chloro-1'H-spiro[indole-3,4'-piperidin]-1'-yl)[(2R)-2,3-dihydro-1,4-benzodioxin-2-yl]methanone | non-polymer | 382.8 | 4 | Chemie (R0D) |
Sequence modifications
A, D, B, C: 85 - 931 (UniProt: Q9Y210)
| PDB | External Database | Details |
|---|---|---|
| Thr 867 | Val 867 | conflict |
| Thr 868 | Leu 868 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 388771.1 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 7804.3 | |
| All* | Total formula weight | 396575.4 |
