1S9I

X-ray structure of the human mitogen-activated protein kinase kinase 2 (MEK2)in a complex with ligand and MgATP

Summary for 1S9I

• Entry DOI: 10.2210/pdb1s9i/pdb
• Related: 1s9j
• Descriptor: Dual specificity mitogen-activated protein kinase kinase 2, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE, ... (4 entities in total)
• Functional Keywords: protein kinase-ligand-mgatp complex, protein-protein interactions, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 81346.29

Authors

Ohren, J.F.,Chen, H.,Pavlovsky, A.,Whitehead, C.,Yan, C.,McConnell, P.,Delaney, A.,Dudley, D.T.,Sebolt-Leopold, J.,Hasemann, C.A. (deposition date: 2004-02-04, release date: 2004-11-23, Last modification date: 2024-04-03)

• Primary citation: Ohren, J.F.,Chen, H.,Pavlovsky, A.,Whitehead, C.,Zhang, E.,Kuffa, P.,Yan, C.,McConnell, P.,Spessard, C.,Banotai, C.,Mueller, W.T.,Delaney, A.,Omer, C.,Sebolt-Leopold, J.,Dudley, D.T.,Leung, I.K.,Flamme, C.,Warmus, J.,Kaufman, M.,Barrett, S.,Tecle, H.,Hasemann, C.A.; Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition.; Nat.Struct.Mol.Biol., 11:1192-1197, 2004; PubMed: 15543157; DOI: 10.1038/nsmb859

Experimental method

X-RAY DIFFRACTION (3.2 Å)