1S9I
X-ray structure of the human mitogen-activated protein kinase kinase 2 (MEK2)in a complex with ligand and MgATP
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Dual specificity mitogen-activated protein kinase kinase 2 | polymer | 354 | 39596.4 | 2 | UniProt (P36507) Pfam (PF00069) In PDB | Homo sapiens (human) | MAP kinase kinase 2, MAPKK 2, ERK activator kinase 2, MAPK/ERK kinase 2, MEK2 |
2 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
3 | A, B | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
4 | A, B | 5-{3,4-DIFLUORO-2-[(2-FLUORO-4-IODOPHENYL)AMINO]PHENYL}-N-(2-MORPHOLIN-4-YLETHYL)-1,3,4-OXADIAZOL-2-AMINE | non-polymer | 545.3 | 2 | Chemie (5EA) |
Sequence modifications
A, B: 55 - 400 (UniProt: P36507)
PDB | External Database | Details |
---|---|---|
Leu 401 | - | cloning artifact |
Glu 402 | - | cloning artifact |
His 403 | - | expression tag |
His 404 | - | expression tag |
His 405 | - | expression tag |
His 406 | - | expression tag |
His 407 | - | expression tag |
His 408 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 79192.7 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 2153.6 | |
All* | Total formula weight | 81346.3 |