1S9I

X-ray structure of the human mitogen-activated protein kinase kinase 2 (MEK2)in a complex with ligand and MgATP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Dual specificity mitogen-activated protein kinase kinase 2	polymer	354	39596.4	2	UniProt (P36507) Pfam (PF00069)	Homo sapiens (human)	MAP kinase kinase 2, MAPKK 2, ERK activator kinase 2, MAPK/ERK kinase 2, MEK2
2	C, F (A, B)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
3	D, G (A, B)	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	2	Chemie (ATP)
4	E, H (A, B)	5-{3,4-DIFLUORO-2-[(2-FLUORO-4-IODOPHENYL)AMINO]PHENYL}-N-(2-MORPHOLIN-4-YLETHYL)-1,3,4-OXADIAZOL-2-AMINE	non-polymer		545.3	2	Chemie (5EA)

Sequence modifications

A, B: 55 - 400 (UniProt: P36507)

PDB	External Database	Details
Leu 401	-	cloning artifact
Glu 402	-	cloning artifact
His 403	-	expression tag
His 404	-	expression tag
His 405	-	expression tag
His 406	-	expression tag
His 407	-	expression tag
His 408	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	79192.7
Non-Polymers*	Number of molecules	6
	Total formula weight	2153.6
All*	Total formula weight	81346.3

*Water molecules are not included.