8JZS
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![BU of 8jzs by Molmil](/molmil-images/mine/8jzs) | Outward-facing SLC15A4 dimer | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, lysosomal transporter | Authors: | Zhang, S.S, Chen, X.D, Xie, M. | Deposit date: | 2023-07-06 | Release date: | 2023-09-27 | Last modified: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (2.95 Å) | Cite: | Structural basis for recruitment of TASL by SLC15A4 in human endolysosomal TLR signaling. Nat Commun, 14, 2023
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8JZU
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![BU of 8jzu by Molmil](/molmil-images/mine/8jzu) | SLC15A4_TASL complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, TLR adapter,Green fluorescent protein, TSLAA-EGPF tag fusion protein | Authors: | Zhang, S.S, Chen, X.D, Xie, M. | Deposit date: | 2023-07-06 | Release date: | 2023-09-27 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.05 Å) | Cite: | Structural basis for recruitment of TASL by SLC15A4 in human endolysosomal TLR signaling. Nat Commun, 14, 2023
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8JZR
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![BU of 8jzr by Molmil](/molmil-images/mine/8jzr) | Outward_facing SLC15A4 monomer | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, lysosomal transporter,ALFA tag | Authors: | Zhang, S.S, Chen, X.D, Xie, M. | Deposit date: | 2023-07-06 | Release date: | 2023-09-27 | Last modified: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (3.25 Å) | Cite: | Structural basis for recruitment of TASL by SLC15A4 in human endolysosomal TLR signaling. Nat Commun, 14, 2023
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8KHD
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![BU of 8khd by Molmil](/molmil-images/mine/8khd) | The interface structure of Omicron RBD binding to 5817 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of 5817, Light chain of 5817, ... | Authors: | Cao, L, Wang, X. | Deposit date: | 2023-08-21 | Release date: | 2024-04-17 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Identification of a broad sarbecovirus neutralizing antibody targeting a conserved epitope on the receptor-binding domain. Cell Rep, 43, 2024
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8KHC
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![BU of 8khc by Molmil](/molmil-images/mine/8khc) | SARS-CoV-2 Omicron spike in complex with 5817 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of 5817 Fab, ... | Authors: | Cao, L, Wang, X. | Deposit date: | 2023-08-21 | Release date: | 2024-04-17 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Identification of a broad sarbecovirus neutralizing antibody targeting a conserved epitope on the receptor-binding domain. Cell Rep, 43, 2024
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6JUI
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![BU of 6jui by Molmil](/molmil-images/mine/6jui) | The atypical Myb-like protein Cdc5 contains two distinct nucleic acid-binding surfaces | Descriptor: | Pre-mRNA-splicing factor CEF1 | Authors: | Wang, C, Li, G, Li, M, Yang, J, Liu, J. | Deposit date: | 2019-04-14 | Release date: | 2020-02-19 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.402 Å) | Cite: | Two distinct nucleic acid binding surfaces of Cdc5 regulate development. Biochem.J., 476, 2019
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6IP4
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![BU of 6ip4 by Molmil](/molmil-images/mine/6ip4) | |
2OKR
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![BU of 2okr by Molmil](/molmil-images/mine/2okr) | Crystal Structure of the P38a-MAPKAP kinase 2 Heterodimer | Descriptor: | MAP kinase-activated protein kinase 2, Mitogen-activated protein kinase 14 | Authors: | Ter Haar, E. | Deposit date: | 2007-01-17 | Release date: | 2007-02-06 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of the P38alpha-MAPKAP kinase 2 heterodimer. J.Biol.Chem., 282, 2007
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2OH0
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![BU of 2oh0 by Molmil](/molmil-images/mine/2oh0) | |
7VKH
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![BU of 7vkh by Molmil](/molmil-images/mine/7vkh) | |
7VKG
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![BU of 7vkg by Molmil](/molmil-images/mine/7vkg) | |
2OJF
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![BU of 2ojf by Molmil](/molmil-images/mine/2ojf) | |
2ONL
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![BU of 2onl by Molmil](/molmil-images/mine/2onl) | Crystal Structure of the p38a-MAPKAP kinase 2 Heterodimer | Descriptor: | MAP kinase-activated protein kinase 2, Mitogen-activated protein kinase 14 | Authors: | Ter Haar, E. | Deposit date: | 2007-01-24 | Release date: | 2007-02-06 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (4 Å) | Cite: | Crystal structure of the P38alpha-MAPKAP kinase 2 heterodimer. J.Biol.Chem., 282, 2007
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8ARD
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![BU of 8ard by Molmil](/molmil-images/mine/8ard) | |
6IP0
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![BU of 6ip0 by Molmil](/molmil-images/mine/6ip0) | |
7Y7J
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![BU of 7y7j by Molmil](/molmil-images/mine/7y7j) | SARS-CoV-2 S trimer in complex with 1F Fab | Descriptor: | 1F VH, 1F VL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Zhao, S, Liu, F, Yang, X, Zhong, G. | Deposit date: | 2022-06-22 | Release date: | 2023-02-22 | Method: | ELECTRON MICROSCOPY (4.8 Å) | Cite: | A core epitope targeting antibody of SARS-CoV-2. Protein Cell, 14, 2023
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7Y7K
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![BU of 7y7k by Molmil](/molmil-images/mine/7y7k) | SARS-CoV-2 RBD in complex with 1F Fab | Descriptor: | 1F VH, 1F VL, Spike protein S1 | Authors: | Zhao, S, Liu, F, Yang, X, Zhong, G. | Deposit date: | 2022-06-22 | Release date: | 2023-02-22 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | A core epitope targeting antibody of SARS-CoV-2. Protein Cell, 14, 2023
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1F5R
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![BU of 1f5r by Molmil](/molmil-images/mine/1f5r) | RAT TRYPSINOGEN MUTANT COMPLEXED WITH BOVINE PANCREATIC TRYPSIN INHIBITOR | Descriptor: | CALCIUM ION, PANCREATIC TRYPSIN INHIBITOR, TRYPSIN II, ... | Authors: | Pasternak, A, White, A, Cahoon, M, Ringe, D, Hedstrom, L. | Deposit date: | 2000-06-15 | Release date: | 2001-07-04 | Last modified: | 2021-11-03 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | The energetic cost of induced fit catalysis: Crystal structures of trypsinogen mutants with enhanced activity and inhibitor affinity. Protein Sci., 10, 2001
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3PWK
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![BU of 3pwk by Molmil](/molmil-images/mine/3pwk) | Crystal Structure of Aspartate beta-Semialdehide Dehydrogenase from Streptococcus pneumoniae with 2',5'-Adenosine diphosphate and D-2-aminoadipate | Descriptor: | 1,2-ETHANEDIOL, 5'-O-MONOPHOSPHORYLADENYLYL(2'->5')ADENYLYL(2'->5')ADENOSINE, Aspartate-semialdehyde dehydrogenase, ... | Authors: | Pavlovsky, A.G, Viola, R.E. | Deposit date: | 2010-12-08 | Release date: | 2012-01-04 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural Characterization of Inhibitors with Selectivity against Members of a Homologous Enzyme Family. Chem.Biol.Drug Des., 79, 2012
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3PZR
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![BU of 3pzr by Molmil](/molmil-images/mine/3pzr) | Crystals structure of aspartate beta-Semialdehyde dehydrogenase from Vibrio Cholerae with NADP and product of S-carbamoyl-L-cysteine | Descriptor: | Aspartate-semialdehyde dehydrogenase, CYSTEINE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Pavlovsky, A.G, Potente, N, Viola, R.E. | Deposit date: | 2010-12-14 | Release date: | 2012-01-04 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structural Characterization of Inhibitors with Selectivity against Members of a Homologous Enzyme Family. Chem.Biol.Drug Des., 79, 2012
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3Q11
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![BU of 3q11 by Molmil](/molmil-images/mine/3q11) | Crystals Structure of Aspartate beta-Semialdehyde Dehydrogenase from Streptococcus pneumoniae with NADP and aspartyl beta-difluorophosphonate | Descriptor: | 1,2-ETHANEDIOL, 5,5-difluoro-4-oxo-5-phosphono-D-norvaline, Aspartate-semialdehyde dehydrogenase, ... | Authors: | Pavlovsky, A.G, Viola, R.E, Faehnle, C.R. | Deposit date: | 2010-12-16 | Release date: | 2012-01-04 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural Characterization of Inhibitors with Selectivity against Members of a Homologous Enzyme Family. Chem.Biol.Drug Des., 79, 2012
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8HBK
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![BU of 8hbk by Molmil](/molmil-images/mine/8hbk) | The crystal structure of SARS-CoV-2 3CL protease in complex with Ensitrelvir | Descriptor: | 3C-like proteinase nsp5, 6-[(6-chloranyl-2-methyl-indazol-5-yl)amino]-3-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-[[2,4,5-tris(fluoranyl)phenyl]methyl]-1,3,5-triazine-2,4-dione | Authors: | Lin, M. | Deposit date: | 2022-10-29 | Release date: | 2023-10-11 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir. Nature, 622, 2023
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6IMC
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![BU of 6imc by Molmil](/molmil-images/mine/6imc) | Crystal Structure of ALKBH1 in complex with Mn(II) and N-Oxalylglycine | Descriptor: | MANGANESE (II) ION, N-OXALYLGLYCINE, Nucleic acid dioxygenase ALKBH1 | Authors: | Zhang, M, Yang, S, Zhao, W, Li, H. | Deposit date: | 2018-10-22 | Release date: | 2020-01-22 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Mammalian ALKBH1 serves as an N6-mA demethylase of unpairing DNA. Cell Res., 30, 2020
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5YPI
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![BU of 5ypi by Molmil](/molmil-images/mine/5ypi) | Crystal structure of NDM-1 bound to hydrolyzed imipenem representing an EI1 complex | Descriptor: | (2R)-2-[(2S,3R)-1,3-bis(oxidanyl)-1-oxidanylidene-butan-2-yl]-4-(2-methanimidamidoethylsulfanyl)-2,3-dihydro-1H-pyrrole -5-carboxylic acid, CHLORIDE ION, GLYCEROL, ... | Authors: | Feng, H, Wang, D, Liu, W. | Deposit date: | 2017-11-01 | Release date: | 2018-02-21 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The mechanism of NDM-1-catalyzed carbapenem hydrolysis is distinct from that of penicillin or cephalosporin hydrolysis. Nat Commun, 8, 2017
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5YPK
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![BU of 5ypk by Molmil](/molmil-images/mine/5ypk) | Crystal structure of NDM-1 bound to hydrolyzed imipenem representing an EI2 complex | Descriptor: | (2R,4S)-2-[(1S,2R)-1-carboxy-2-hydroxypropyl]-4-[(2-{[(Z)-iminomethyl]amino}ethyl)sulfanyl]-3,4-dihydro-2H-pyrrole-5-ca rboxylic acid, CHLORIDE ION, Metallo-beta-lactamase NDM-1, ... | Authors: | Feng, H, Wang, D, Liu, W. | Deposit date: | 2017-11-02 | Release date: | 2018-02-21 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The mechanism of NDM-1-catalyzed carbapenem hydrolysis is distinct from that of penicillin or cephalosporin hydrolysis. Nat Commun, 8, 2017
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