5YPK

Crystal structure of NDM-1 bound to hydrolyzed imipenem representing an EI2 complex

Summary for 5YPK

• Entry DOI: 10.2210/pdb5ypk/pdb
• Descriptor: Metallo-beta-lactamase NDM-1, ZINC ION, (2R,4S)-2-[(1S,2R)-1-carboxy-2-hydroxypropyl]-4-[(2-{[(Z)-iminomethyl]amino}ethyl)sulfanyl]-3,4-dihydro-2H-pyrrole-5-ca rboxylic acid, ... (7 entities in total)
• Functional Keywords: ndm-1, imipenem, ei2 complex, hydrolase
• Biological source: Escherichia coli
• Total number of polymer chains: 8
• Total formula weight: 209508.82

Authors

Feng, H.,Wang, D.,Liu, W. (deposition date: 2017-11-02, release date: 2018-02-21, Last modification date: 2023-11-22)

• Primary citation: Feng, H.,Liu, X.,Wang, S.,Fleming, J.,Wang, D.C.,Liu, W.; The mechanism of NDM-1-catalyzed carbapenem hydrolysis is distinct from that of penicillin or cephalosporin hydrolysis.; Nat Commun, 8:2242-2242, 2017; PubMed: 29269938; DOI: 10.1038/s41467-017-02339-w

Experimental method

X-RAY DIFFRACTION (2 Å)