1Y43
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![BU of 1y43 by Molmil](/molmil-images/mine/1y43) | crystal structure of aspergilloglutamic peptidase from Aspergillus niger | Descriptor: | Aspergillopepsin II heavy chain, Aspergillopepsin II light chain, SULFATE ION | Authors: | Sasaki, H, Nakagawa, A, Iwata, S, Muramatsu, T, Suganuma, M, Sawano, Y, Kojima, M, Kubota, K, Takahashi, K. | Deposit date: | 2004-11-30 | Release date: | 2005-12-13 | Last modified: | 2013-02-27 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | The three-dimensional structure of aspergilloglutamic peptidase from Aspergillus niger Proc.Jpn.Acad.,Ser.B, 80, 2004
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4GFM
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![BU of 4gfm by Molmil](/molmil-images/mine/4gfm) | JAK2 kinase (JH1 domain) with 2,6-DICHLORO-N-(2-OXO-2,5-DIHYDROPYRIDIN-4-YL)BENZAMIDE | Descriptor: | 2,6-dichloro-N-(2-oxo-2,5-dihydropyridin-4-yl)benzamide, Tyrosine-protein kinase JAK2 | Authors: | Eigenbrot, C, Ultsch, M. | Deposit date: | 2012-08-03 | Release date: | 2013-06-19 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Lead identification of novel and selective TYK2 inhibitors. Eur.J.Med.Chem., 67, 2013
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6VIH
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![BU of 6vih by Molmil](/molmil-images/mine/6vih) | The ligand-free structure of mouse RABL3 | Descriptor: | Rab-like protein 3 | Authors: | Su, L, Tomchick, D.R, Beutler, B. | Deposit date: | 2020-01-13 | Release date: | 2020-04-08 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.993 Å) | Cite: | Genetic and structural studies of RABL3 reveal an essential role in lymphoid development and function. Proc.Natl.Acad.Sci.USA, 117, 2020
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4GMY
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![BU of 4gmy by Molmil](/molmil-images/mine/4gmy) | |
4GIH
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8BFU
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![BU of 8bfu by Molmil](/molmil-images/mine/8bfu) | Crystal structure of the apo p110alpha catalytic subunit from homo sapiens | Descriptor: | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | Authors: | Gong, G.Q, Bellini, D, Vanhaesebroeck, B, Williams, R.L. | Deposit date: | 2022-10-26 | Release date: | 2023-02-15 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | A small-molecule PI3K alpha activator for cardioprotection and neuroregeneration. Nature, 618, 2023
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2AFN
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![BU of 2afn by Molmil](/molmil-images/mine/2afn) | STRUCTURE OF ALCALIGENES FAECALIS NITRITE REDUCTASE AND A COPPER SITE MUTANT, M150E, THAT CONTAINS ZINC | Descriptor: | COPPER (II) ION, NITRITE REDUCTASE | Authors: | Murphy, M.E.P, Adman, E.T, Turley, S. | Deposit date: | 1995-07-03 | Release date: | 1996-08-01 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of Alcaligenes faecalis nitrite reductase and a copper site mutant, M150E, that contains zinc. Biochemistry, 34, 1995
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2EXV
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![BU of 2exv by Molmil](/molmil-images/mine/2exv) | Crystal structure of the F7A mutant of the cytochrome c551 from Pseudomonas aeruginosa | Descriptor: | ACETIC ACID, Cytochrome c-551, HEME C | Authors: | Bonivento, D, Di Matteo, A, Borgia, A, Travaglini-Allocatelli, C, Brunori, M. | Deposit date: | 2005-11-09 | Release date: | 2006-02-07 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Unveiling a Hidden Folding Intermediate in c-Type Cytochromes by Protein Engineering J.Biol.Chem., 281, 2006
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1DJX
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![BU of 1djx by Molmil](/molmil-images/mine/1djx) | PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C-DELTA1 FROM RAT COMPLEXED WITH INOSITOL-1,4,5-TRISPHOSPHATE | Descriptor: | ACETATE ION, CALCIUM ION, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, ... | Authors: | Essen, L.-O, Perisic, O, Williams, R.L. | Deposit date: | 1996-08-24 | Release date: | 1997-07-07 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural mapping of the catalytic mechanism for a mammalian phosphoinositide-specific phospholipase C. Biochemistry, 36, 1997
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1IQW
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![BU of 1iqw by Molmil](/molmil-images/mine/1iqw) | CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF THE MOUSE ANTI-HUMAN FAS ANTIBODY HFE7A | Descriptor: | ANTIBODY M-HFE7A, HEAVY CHAIN, LIGHT CHAIN | Authors: | Ito, S, Takayama, T, Hanzawa, H, Ichikawa, K, Ohsumi, J, Serizawa, N, Hata, T, Haruyama, H. | Deposit date: | 2001-08-10 | Release date: | 2002-01-23 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of the antigen-binding fragment of apoptosis-inducing mouse anti-human Fas monoclonal antibody HFE7A. J.Biochem., 131, 2002
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4L98
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![BU of 4l98 by Molmil](/molmil-images/mine/4l98) | Crystal structure of the complex of F360L PPARgamma mutant with the ligand LT175 | Descriptor: | (2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid, Peroxisome proliferator-activated receptor gamma | Authors: | Pochetti, G, Montanari, R, Consalvi, V, Chiaraluce, R, Pasquo, A, Capelli, D, Loiodice, F, Laghezza, A, Lori, C. | Deposit date: | 2013-06-18 | Release date: | 2014-06-25 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Structural basis of the transactivation deficiency of the human PPAR gamma F360L mutant associated with familial partial lipodystrophy. Acta Crystallogr.,Sect.D, 70, 2014
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5B5T
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![BU of 5b5t by Molmil](/molmil-images/mine/5b5t) | Crystal Structure of Escherichia coli Gamma-Glutamyltranspeptidase in Complex with peptidyl phosphonate inhibitor 1b | Descriptor: | (2~{S})-2-azanyl-4-[(2~{R})-1-(2-hydroxy-2-oxoethylamino)-1-oxidanylidene-butan-2-yl]oxyphosphonoyl-butanoic acid, CALCIUM ION, Gamma-glutamyltranspeptidase large chain, ... | Authors: | Wada, K, Fukuyama, K. | Deposit date: | 2016-05-18 | Release date: | 2016-09-28 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Phosphonate-based irreversible inhibitors of human gamma-glutamyl transpeptidase (GGT). GGsTop is a non-toxic and highly selective inhibitor with critical electrostatic interaction with an active-site residue Lys562 for enhanced inhibitory activity Bioorg.Med.Chem., 24, 2016
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6JEO
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![BU of 6jeo by Molmil](/molmil-images/mine/6jeo) | Structure of PSI tetramer from Anabaena | Descriptor: | 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, BETA-CAROTENE, ... | Authors: | Kato, K, Nagao, R, Shen, J.R, Miyazaki, N, Akita, F. | Deposit date: | 2019-02-06 | Release date: | 2019-11-13 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structure of a cyanobacterial photosystem I tetramer revealed by cryo-electron microscopy. Nat Commun, 10, 2019
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7ZUR
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![BU of 7zur by Molmil](/molmil-images/mine/7zur) | Four carbons pendant pyridine derivative of the natural alkaloid Berberine as Human Telomeric G-quadruplex Binder | Descriptor: | 16,17-dimethoxy-21-(4-pyridin-4-ylbutyl)-5,7-dioxa-13$l^{4}-azapentacyclo[11.8.0.0^{2,10}.0^{4,8}.0^{15,20}]henicosa-1(21),2(10),3,8,13,15,17,19-octaene, DNA TAGGGTTAGGGT, POTASSIUM ION | Authors: | Bazzicalupi, C, Ferraroni, M, Gratteri, P, Papi, F. | Deposit date: | 2022-05-13 | Release date: | 2022-12-07 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Probing the Efficiency of 13-Pyridylalkyl Berberine Derivatives to Human Telomeric G-Quadruplexes Binding: Spectroscopic, Solid State and In Silico Analysis. Int J Mol Sci, 23, 2022
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2E0M
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![BU of 2e0m by Molmil](/molmil-images/mine/2e0m) | Mutant Human Ribonuclease 1 (T24L, Q28L, R31L, R32L) | Descriptor: | CADMIUM ION, CHLORIDE ION, Ribonuclease | Authors: | Yamada, H, Tamada, T, Kosaka, M, Kuroki, R. | Deposit date: | 2006-10-10 | Release date: | 2007-08-28 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | 'Crystal lattice engineering,' an approach to engineer protein crystal contacts by creating intermolecular symmetry: crystallization and structure determination of a mutant human RNase 1 with a hydrophobic interface of leucines Protein Sci., 16, 2007
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4L96
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![BU of 4l96 by Molmil](/molmil-images/mine/4l96) | Structure of the complex between the F360L PPARgamma mutant and the ligand LT175 (space group I222) | Descriptor: | (2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid, Peroxisome proliferator-activated receptor gamma | Authors: | Pochetti, G, Montanari, R, Capelli, D, Chiaraluce, R, Consalvi, V, Pasquo, A, Lori, C, Laghezza, A, Loiodice, F. | Deposit date: | 2013-06-18 | Release date: | 2014-06-25 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.38 Å) | Cite: | Structural basis of the transactivation deficiency of the human PPAR gamma F360L mutant associated with familial partial lipodystrophy. Acta Crystallogr.,Sect.D, 70, 2014
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7WBZ
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![BU of 7wbz by Molmil](/molmil-images/mine/7wbz) | Crystal structure of the SARS-Cov-2 RBD in complex with Fab 2303 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2303 heavy chain, 2303 light chain, ... | Authors: | Xiang, Y, Ma, B. | Deposit date: | 2021-12-17 | Release date: | 2022-08-31 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.42 Å) | Cite: | Conformational flexibility in neutralization of SARS-CoV-2 by naturally elicited anti-SARS-CoV-2 antibodies. Commun Biol, 5, 2022
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2E0O
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![BU of 2e0o by Molmil](/molmil-images/mine/2e0o) | Mutant Human Ribonuclease 1 (V52L, D53L, N56L, F59L) | Descriptor: | GLYCEROL, Ribonuclease, SULFATE ION | Authors: | Yamada, H, Tamada, T, Kosaka, M, Kuroki, R. | Deposit date: | 2006-10-10 | Release date: | 2007-08-28 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | 'Crystal lattice engineering,' an approach to engineer protein crystal contacts by creating intermolecular symmetry: crystallization and structure determination of a mutant human RNase 1 with a hydrophobic interface of leucines Protein Sci., 16, 2007
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8AAD
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![BU of 8aad by Molmil](/molmil-images/mine/8aad) | Two carbons pendant pyridine derivative of the natural alkaloid Berberine as Human Telomeric G-quadruplex Binder | Descriptor: | 16,17-dimethoxy-21-(2-pyridin-4-ylethyl)-5,7-dioxa-13$l^{4}-azapentacyclo[11.8.0.0^{2,10}.0^{4,8}.0^{15,20}]henicosa-1(13),2,4(8),9,14,16,18,20-octaene, DNA TAGGGTTAGGGT, POTASSIUM ION | Authors: | Ferraroni, M, Bazzicalupi, C, Gratteri, P, Papi, F. | Deposit date: | 2022-07-01 | Release date: | 2022-12-07 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Probing the Efficiency of 13-Pyridylalkyl Berberine Derivatives to Human Telomeric G-Quadruplexes Binding: Spectroscopic, Solid State and In Silico Analysis. Int J Mol Sci, 23, 2022
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2E0L
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![BU of 2e0l by Molmil](/molmil-images/mine/2e0l) | Mutant Human Ribonuclease 1 (Q28L, R31L, R32L) | Descriptor: | CADMIUM ION, CHLORIDE ION, Ribonuclease | Authors: | Yamada, H, Tamada, T, Kosaka, M, Kuroki, R. | Deposit date: | 2006-10-10 | Release date: | 2007-08-28 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | 'Crystal lattice engineering,' an approach to engineer protein crystal contacts by creating intermolecular symmetry: crystallization and structure determination of a mutant human RNase 1 with a hydrophobic interface of leucines Protein Sci., 16, 2007
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2E0J
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![BU of 2e0j by Molmil](/molmil-images/mine/2e0j) | Mutant Human Ribonuclease 1 (R31L, R32L) | Descriptor: | Ribonuclease | Authors: | Yamada, H, Tamada, T, Kosaka, M, Kuroki, R. | Deposit date: | 2006-10-10 | Release date: | 2007-08-28 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | 'Crystal lattice engineering,' an approach to engineer protein crystal contacts by creating intermolecular symmetry: crystallization and structure determination of a mutant human RNase 1 with a hydrophobic interface of leucines Protein Sci., 16, 2007
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7WC0
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7WCD
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![BU of 7wcd by Molmil](/molmil-images/mine/7wcd) | Cryo EM structure of SARS-CoV-2 spike in complex with TAU-2212 mAbs in conformation 4 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain, Light chain, ... | Authors: | Xiang, Y, Ma, B, Li, R. | Deposit date: | 2021-12-19 | Release date: | 2022-08-10 | Last modified: | 2022-08-17 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Conformational flexibility in neutralization of SARS-CoV-2 by naturally elicited anti-SARS-CoV-2 antibodies. Commun Biol, 5, 2022
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8B5Y
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![BU of 8b5y by Molmil](/molmil-images/mine/8b5y) | SHP2 in complex with allosteric imidazopyrazine inhibitor | Descriptor: | (1~{S})-1'-[5-[2-(trifluoromethyl)pyridin-3-yl]sulfanyl-3~{H}-imidazo[4,5-b]pyrazin-2-yl]spiro[1,3-dihydroindene-2,4'-piperidine]-1-amine, FORMIC ACID, Tyrosine-protein phosphatase non-receptor type 11 | Authors: | Torrente, E, Petrocchi, A. | Deposit date: | 2022-09-25 | Release date: | 2023-01-18 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Discovery of a Novel Series of Imidazopyrazine Derivatives as Potent SHP2 Allosteric Inhibitors. Acs Med.Chem.Lett., 14, 2023
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5KZV
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![BU of 5kzv by Molmil](/molmil-images/mine/5kzv) | Crystal structure of the xenopus Smoothened cysteine-rich domain (CRD) in complex with 20(S)-hydroxycholesterol | Descriptor: | (3alpha,8alpha)-cholest-5-ene-3,20-diol, Smoothened | Authors: | Huang, P, Kim, Y, Salic, A. | Deposit date: | 2016-07-25 | Release date: | 2016-08-17 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.616 Å) | Cite: | Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling. Cell, 166, 2016
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