4GFM
JAK2 kinase (JH1 domain) with 2,6-DICHLORO-N-(2-OXO-2,5-DIHYDROPYRIDIN-4-YL)BENZAMIDE
Summary for 4GFM
Entry DOI | 10.2210/pdb4gfm/pdb |
Related | 4GFO 4GIH 4GMY |
Descriptor | Tyrosine-protein kinase JAK2, 2,6-dichloro-N-(2-oxo-2,5-dihydropyridin-4-yl)benzamide (3 entities in total) |
Functional Keywords | o-phosphotyrosine, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Endomembrane system; Peripheral membrane protein (By similarity): O60674 |
Total number of polymer chains | 1 |
Total formula weight | 35769.36 |
Authors | Eigenbrot, C.,Ultsch, M. (deposition date: 2012-08-03, release date: 2013-06-19, Last modification date: 2023-12-06) |
Primary citation | Liang, J.,Tsui, V.,Van Abbema, A.,Bao, L.,Barrett, K.,Beresini, M.,Berezhkovskiy, L.,Blair, W.S.,Chang, C.,Driscoll, J.,Eigenbrot, C.,Ghilardi, N.,Gibbons, P.,Halladay, J.,Johnson, A.,Kohli, P.B.,Lai, Y.,Liimatta, M.,Mantik, P.,Menghrajani, K.,Murray, J.,Sambrone, A.,Xiao, Y.,Shia, S.,Shin, Y.,Smith, J.,Sohn, S.,Stanley, M.,Ultsch, M.,Zhang, B.,Wu, L.C.,Magnuson, S. Lead identification of novel and selective TYK2 inhibitors. Eur.J.Med.Chem., 67:175-187, 2013 Cited by PubMed: 23867602DOI: 10.1016/j.ejmech.2013.03.070 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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