7ZUR

Four carbons pendant pyridine derivative of the natural alkaloid Berberine as Human Telomeric G-quadruplex Binder

Summary for 7ZUR

• Entry DOI: 10.2210/pdb7zur/pdb
• Related: 6S15
• Descriptor: DNA TAGGGTTAGGGT, POTASSIUM ION, 16,17-dimethoxy-21-(4-pyridin-4-ylbutyl)-5,7-dioxa-13$l^{4}-azapentacyclo[11.8.0.0^{2,10}.0^{4,8}.0^{15,20}]henicosa-1(21),2(10),3,8,13,15,17,19-octaene, ... (4 entities in total)
• Functional Keywords: drug-dna complex, telomeric g-quadruplex, dna
• Biological source: Homo sapiens
• Total number of polymer chains: 1
• Total formula weight: 4321.21

Authors

Bazzicalupi, C.,Ferraroni, M.,Gratteri, P.,Papi, F. (deposition date: 2022-05-13, release date: 2022-12-07, Last modification date: 2024-01-31)

• Primary citation: Bazzicalupi, C.,Bonardi, A.,Biver, T.,Ferraroni, M.,Papi, F.,Savastano, M.,Lombardi, P.,Gratteri, P.; Probing the Efficiency of 13-Pyridylalkyl Berberine Derivatives to Human Telomeric G-Quadruplexes Binding: Spectroscopic, Solid State and In Silico Analysis.; Int J Mol Sci, 23:-, 2022; PubMed: 36430540; DOI: 10.3390/ijms232214061

Experimental method

X-RAY DIFFRACTION (1.6 Å)