Structure of the complex between the F360L PPARgamma mutant and the ligand LT175 (space group I222)

Summary for 4L96

Related3B3K 4L98
DescriptorPeroxisome proliferator-activated receptor gamma, (2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid (3 entities in total)
Functional Keywordstranscription factor, rxralpha, transcription-transcription inhibitor complex, transcription/transcription inhibitor
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total molecular weight31694.84
Pochetti, G.,Montanari, R.,Capelli, D.,Chiaraluce, R.,Consalvi, V.,Pasquo, A.,Lori, C.,Laghezza, A.,Loiodice, F. (deposition date: 2013-06-18, release date: 2014-06-25, Last modification date: 2019-07-17)
Primary citation
Lori, C.,Pasquo, A.,Montanari, R.,Capelli, D.,Consalvi, V.,Chiaraluce, R.,Cervoni, L.,Loiodice, F.,Laghezza, A.,Aschi, M.,Giorgi, A.,Pochetti, G.
Structural basis of the transactivation deficiency of the human PPAR gamma F360L mutant associated with familial partial lipodystrophy.
Acta Crystallogr.,Sect.D, 70:1965-1976, 2014
PubMed: 25004973 (PDB entries with the same primary citation)
DOI: 10.1107/S1399004714009638
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2354 1.2% 2.6% 7.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report