8AAD

Two carbons pendant pyridine derivative of the natural alkaloid Berberine as Human Telomeric G-quadruplex Binder

Summary for 8AAD

• Entry DOI: 10.2210/pdb8aad/pdb
• Related: 6S15 7ZUR
• Descriptor: DNA TAGGGTTAGGGT, POTASSIUM ION, 16,17-dimethoxy-21-(2-pyridin-4-ylethyl)-5,7-dioxa-13$l^{4}-azapentacyclo[11.8.0.0^{2,10}.0^{4,8}.0^{15,20}]henicosa-1(13),2,4(8),9,14,16,18,20-octaene, ... (4 entities in total)
• Functional Keywords: drug-dna complex, telomeric g-quadruplex, dna
• Biological source: Homo sapiens
• Total number of polymer chains: 1
• Total formula weight: 4293.16

Authors

Ferraroni, M.,Bazzicalupi, C.,Gratteri, P.,Papi, F. (deposition date: 2022-07-01, release date: 2022-12-07, Last modification date: 2024-01-31)

• Primary citation: Bazzicalupi, C.,Bonardi, A.,Biver, T.,Ferraroni, M.,Papi, F.,Savastano, M.,Lombardi, P.,Gratteri, P.; Probing the Efficiency of 13-Pyridylalkyl Berberine Derivatives to Human Telomeric G-Quadruplexes Binding: Spectroscopic, Solid State and In Silico Analysis.; Int J Mol Sci, 23:-, 2022; PubMed: 36430540; DOI: 10.3390/ijms232214061

Experimental method

X-RAY DIFFRACTION (2.04 Å)