4GIH

Tyk2 (JH1) in complex with 2,6-DICHLORO-N-{2-[(CYCLOPROPYLCARBONYL)AMINO]PYRIDIN-4-YL}BENZAMIDE

Summary for 4GIH

• Entry DOI: 10.2210/pdb4gih/pdb
• Related: 4GFM 4GFO 4GII 4GJ2 4GJ3 4GMY 4GVJ
• Descriptor: Non-receptor tyrosine-protein kinase TYK2, 2,6-dichloro-N-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide (3 entities in total)
• Functional Keywords: tyrosine kinase, kinase, atp binding, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 35098.93

Authors

Ultsch, M.H. (deposition date: 2012-08-08, release date: 2013-06-19, Last modification date: 2023-09-13)

• Primary citation: Liang, J.,Tsui, V.,Van Abbema, A.,Bao, L.,Barrett, K.,Beresini, M.,Berezhkovskiy, L.,Blair, W.S.,Chang, C.,Driscoll, J.,Eigenbrot, C.,Ghilardi, N.,Gibbons, P.,Halladay, J.,Johnson, A.,Kohli, P.B.,Lai, Y.,Liimatta, M.,Mantik, P.,Menghrajani, K.,Murray, J.,Sambrone, A.,Xiao, Y.,Shia, S.,Shin, Y.,Smith, J.,Sohn, S.,Stanley, M.,Ultsch, M.,Zhang, B.,Wu, L.C.,Magnuson, S.; Lead identification of novel and selective TYK2 inhibitors.; Eur.J.Med.Chem., 67:175-187, 2013; PubMed: 23867602; DOI: 10.1016/j.ejmech.2013.03.070

Experimental method

X-RAY DIFFRACTION (2 Å)