8BFU

Crystal structure of the apo p110alpha catalytic subunit from homo sapiens

Summary for 8BFU

Entry DOI	10.2210/pdb8bfu/pdb
Descriptor	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (2 entities in total)
Functional Keywords	pi3k, pik3ca, oncoprotein, p110, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	109983.09
Authors	Gong, G.Q.,Bellini, D.,Vanhaesebroeck, B.,Williams, R.L. (deposition date: 2022-10-26, release date: 2023-02-15, Last modification date: 2024-02-07)
Primary citation	Gong, G.Q.,Bilanges, B.,Allsop, B.,Masson, G.R.,Roberton, V.,Askwith, T.,Oxenford, S.,Madsen, R.R.,Conduit, S.E.,Bellini, D.,Fitzek, M.,Collier, M.,Najam, O.,He, Z.,Wahab, B.,McLaughlin, S.H.,Chan, A.W.E.,Feierberg, I.,Madin, A.,Morelli, D.,Bhamra, A.,Vinciauskaite, V.,Anderson, K.E.,Surinova, S.,Pinotsis, N.,Lopez-Guadamillas, E.,Wilcox, M.,Hooper, A.,Patel, C.,Whitehead, M.A.,Bunney, T.D.,Stephens, L.R.,Hawkins, P.T.,Katan, M.,Yellon, D.M.,Davidson, S.M.,Smith, D.M.,Phillips, J.B.,Angell, R.,Williams, R.L.,Vanhaesebroeck, B. A small-molecule PI3K alpha activator for cardioprotection and neuroregeneration. Nature, 618:159-168, 2023 Cited by PubMed: 37225977 DOI: 10.1038/s41586-023-05972-2 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.41 Å)

Structure validation