8BHT
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![BU of 8bht by Molmil](/molmil-images/mine/8bht) | ABCG2 turnover-1 state with tariquidar bound | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Broad substrate specificity ATP-binding cassette transporter ABCG2, CHOLESTEROL, ... | Authors: | Yu, Q, Kowal, J, Tajkhorshid, E, Locher, K.P. | Deposit date: | 2022-10-31 | Release date: | 2023-01-11 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Differential dynamics and direct interaction of bound ligands with lipids in multidrug transporter ABCG2. Proc.Natl.Acad.Sci.USA, 120, 2023
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8BI0
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![BU of 8bi0 by Molmil](/molmil-images/mine/8bi0) | ABCG2 turnover-2 state with tariquidar bound | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Broad substrate specificity ATP-binding cassette transporter ABCG2, CHOLESTEROL, ... | Authors: | Yu, Q, Kowal, J, Tajkhorshid, E, Locher, K.P. | Deposit date: | 2022-11-01 | Release date: | 2023-01-11 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Differential dynamics and direct interaction of bound ligands with lipids in multidrug transporter ABCG2. Proc.Natl.Acad.Sci.USA, 120, 2023
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8FD4
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![BU of 8fd4 by Molmil](/molmil-images/mine/8fd4) | |
7YX9
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![BU of 7yx9 by Molmil](/molmil-images/mine/7yx9) | |
7YXB
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![BU of 7yxb by Molmil](/molmil-images/mine/7yxb) | MHC-II dynamics are maintained in HLA-DR allotypes to ensure catalyzed peptide exchange | Descriptor: | 1,2-ETHANEDIOL, CITRATE ANION, CLIP peptide, ... | Authors: | Roske, Y, Abualrous, E.T, Freund, C. | Deposit date: | 2022-02-15 | Release date: | 2023-02-22 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.095 Å) | Cite: | MHC-II dynamics are maintained in HLA-DR allotypes to ensure catalyzed peptide exchange. Nat.Chem.Biol., 19, 2023
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7Z0Q
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![BU of 7z0q by Molmil](/molmil-images/mine/7z0q) | MHC-II dynamics are maintained in HLA-DR allotypes to ensure catalyzed peptide exchange | Descriptor: | 1,2-ETHANEDIOL, CLIP peptide, HLA class II histocompatibility antigen, ... | Authors: | Roske, Y, Abualrous, E.T, Freund, C. | Deposit date: | 2022-02-23 | Release date: | 2023-03-08 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | MHC-II dynamics are maintained in HLA-DR allotypes to ensure catalyzed peptide exchange. Nat.Chem.Biol., 19, 2023
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4RCL
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![BU of 4rcl by Molmil](/molmil-images/mine/4rcl) | |
1TFR
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![BU of 1tfr by Molmil](/molmil-images/mine/1tfr) | RNASE H FROM BACTERIOPHAGE T4 | Descriptor: | MAGNESIUM ION, T4 RNASE H | Authors: | Mueser, T.C, Nossal, N.G, Hyde, C.C. | Deposit date: | 1996-04-27 | Release date: | 1996-11-08 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | Structure of bacteriophage T4 RNase H, a 5' to 3' RNA-DNA and DNA-DNA exonuclease with sequence similarity to the RAD2 family of eukaryotic proteins. Cell(Cambridge,Mass.), 85, 1996
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4KK7
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![BU of 4kk7 by Molmil](/molmil-images/mine/4kk7) | |
4L4W
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![BU of 4l4w by Molmil](/molmil-images/mine/4l4w) | |
3WQR
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![BU of 3wqr by Molmil](/molmil-images/mine/3wqr) | Crystal structure of pfdxr complexed with inhibitor-12 | Descriptor: | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplast, CALCIUM ION, ... | Authors: | Tanaka, N, Umeda, T. | Deposit date: | 2014-01-31 | Release date: | 2014-11-26 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Binding Modes of Reverse Fosmidomycin Analogs toward the Antimalarial Target IspC. J.Med.Chem., 57, 2014
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4KV2
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![BU of 4kv2 by Molmil](/molmil-images/mine/4kv2) | |
4KV3
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![BU of 4kv3 by Molmil](/molmil-images/mine/4kv3) | |
5SXL
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![BU of 5sxl by Molmil](/molmil-images/mine/5sxl) | |
5VBA
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![BU of 5vba by Molmil](/molmil-images/mine/5vba) | |
3WQQ
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![BU of 3wqq by Molmil](/molmil-images/mine/3wqq) | Crystal structure of PfDXR complexed with inhibitor-3 | Descriptor: | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplast, CALCIUM ION, ... | Authors: | Tanaka, N, Umeda, T. | Deposit date: | 2014-01-31 | Release date: | 2014-11-26 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Binding Modes of Reverse Fosmidomycin Analogs toward the Antimalarial Target IspC. J.Med.Chem., 57, 2014
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3WQS
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![BU of 3wqs by Molmil](/molmil-images/mine/3wqs) | Crystal structure of pfdxr complexed with inhibitor-126 | Descriptor: | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplast, MAGNESIUM ION, ... | Authors: | Tanaka, N, Umeda, T. | Deposit date: | 2014-01-31 | Release date: | 2014-11-26 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Binding Modes of Reverse Fosmidomycin Analogs toward the Antimalarial Target IspC. J.Med.Chem., 57, 2014
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5E1S
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![BU of 5e1s by Molmil](/molmil-images/mine/5e1s) | The Crystal structure of INSR Tyrosine Kinase in complex with the Inhibitor BI 885578 | Descriptor: | (5R)-N-(1-{2-[4-(2-methoxyethyl)piperazin-1-yl]ethyl}-1H-pyrazol-3-yl)-5,8-dimethyl-9-phenyl-6,8-dihydro-5H-pyrazolo[3,4-h]quinazolin-2-amine, Insulin receptor | Authors: | Kessler, D, Zahn, S, Sanderson, M, Wolkerstorfer, B. | Deposit date: | 2015-09-30 | Release date: | 2015-10-14 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.264 Å) | Cite: | BI 885578, a Novel IGF1R/INSR Tyrosine Kinase Inhibitor with Pharmacokinetic Properties That Dissociate Antitumor Efficacy and Perturbation of Glucose Homeostasis. Mol.Cancer Ther., 14, 2015
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4KP7
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![BU of 4kp7 by Molmil](/molmil-images/mine/4kp7) | Structure of Plasmodium IspC in complex with a beta-thia-isostere derivative of Fosmidomycin | Descriptor: | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplast, MANGANESE (III) ION, ... | Authors: | Kunfermann, A, Bacher, A, Groll, M. | Deposit date: | 2013-05-13 | Release date: | 2013-10-02 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | IspC as Target for Antiinfective Drug Discovery: Synthesis, Enantiomeric Separation, and Structural Biology of Fosmidomycin Thia Isosters. J.Med.Chem., 56, 2013
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4ZAK
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![BU of 4zak by Molmil](/molmil-images/mine/4zak) | Crystal structure of the mCD1d/DB06-1/iNKTCR ternary complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antigen-presenting glycoprotein CD1d1, ... | Authors: | Zajonc, D.M, Birkholz, A.M. | Deposit date: | 2015-04-13 | Release date: | 2015-07-01 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.824 Å) | Cite: | A Novel Glycolipid Antigen for NKT Cells That Preferentially Induces IFN-gamma Production. J Immunol., 195, 2015
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3SXU
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![BU of 3sxu by Molmil](/molmil-images/mine/3sxu) | |
2BHJ
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![BU of 2bhj by Molmil](/molmil-images/mine/2bhj) | murine iNO synthase with coumarin inhibitor | Descriptor: | 7,8-DIHYDROBIOPTERIN, NITRIC OXIDE SYNTHASE, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Mathieu, M, Guilloteau, J.P. | Deposit date: | 2005-01-12 | Release date: | 2005-03-31 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Design, Synthesis and Characterization of a Novel Class of Coumarin-Based Inhibitors of Inducible Nitric Oxide Synthase Bioorg.Med.Chem., 13, 2005
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